obsolete adenylate cyclase-activating adrenergic receptor signaling pathway involved in positive regulation of heart rate
Ontology
biological_process
Synonyms
Gs-coupled adrenergic receptor signaling pathway involved in positive regulation of heart rate, If activation by beta-adrenergic receptor signaling pathway, activation of funny current by beta-adrenergic receptor signaling pathway, adenylate cyclase-activating cardiac adrenergic receptor signaling pathway, beta adrenergic receptor signaling pathway involved in positive regulation of heart rate, adrenergic receptor signaling pathway involved in positive regulation of heart rate, adrenergic receptor signalling pathway involved in positive regulation of heart rate
Alternate IDs
None
Definition
OBSOLETE. An adrenergic receptor signaling pathway that contributes to an increase in frequency or rate of heart contraction. Binding of adrenalin or noradrenalin to a beta-adrenergic receptor on the surface of the signal-receiving cell results in the activation of an intracellular Gs protein. Gs activates adenylate cyclase to increase intracellular cyclic-AMP (cAMP) levels. cAMP binds directly to F-channels to allow an inward flow of sodium (known as funny current, or If current). The funny current is responsible for membrane depolarization and an increase in heart rate.
Source:
GOC:BHF,
GOC:bf,
PMID:21099118,
GOC:mtg_cardiac_conduct_nov11
Comment
This term was obsoleted because it represents a GO-CAM pathway.
Link
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