AmiGO 2: Term Details for "adenylate cyclase-activating adrenergic receptor signaling pathway involved in cardiac muscle relaxation" (GO:0086030)

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Term Information

Accession: GO:0086030
Name: adenylate cyclase-activating adrenergic receptor signaling pathway involved in cardiac muscle relaxation
Ontology: biological_process
Synonyms: Gs-coupled adrenergic receptor signaling pathway involved in cardiac muscle relaxation, adrenergic receptor signaling pathway involved in cardiac muscle relaxation, adrenergic receptor signaling pathway involved in cardiac muscle relaxation via activation of AC, adrenergic receptor-induced cardiac relaxation
Alternate IDs: None
Definition: An adrenergic receptor signaling pathway that contributes to a reduction in cardiac muscle contraction. Beta-adrenergic receptor-induced cardiac relaxation is achieved by a GPCR-activated adenylate cyclase generating cAMP; cAMP then activates the cAMP-dependent protein kinase A (PKA), which phosphorylates the sarcoplasmic reticulum (SR) membrane protein PLB. In its non-phosphorylated state, PLB acts as an inhibitor of the ATPase Ca(2+) pump of the cardiac SR (SERCA2a); inhibition of the pump is relieved upon phosphorylation. The pump removes Ca(2+) from the cytoplasm, thereby preventing cytosolic Ca(2+)-dependent activation of contractile proteins, leading to enhanced muscle relaxation. Source: GOC:BHF, PMID:10571541, GOC:mtg_cardiac_conduct_nov11
Comment: None
History: See term history for GO:0086030 at QuickGO
Chem. react.: None
Subset: None
Related: Link to all genes and gene products annotated to adenylate cyclase-activating adrenergic receptor signaling pathway involved in cardiac muscle relaxation (excluding "regulates").; Link to all direct and indirect annotations to adenylate cyclase-activating adrenergic receptor signaling pathway involved in cardiac muscle relaxation (excluding "regulates").; Link to all direct and indirect annotations download (limited to first 10,000) for adenylate cyclase-activating adrenergic receptor signaling pathway involved in cardiac muscle relaxation (excluding "regulates").

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CARO:0030000 biological entity
CARO:0000000 anatomical entity
GO:0008150 biological_process
UBERON:0001062 anatomical entity
UBERON:0000061 anatomical structure
UBERON:0000467 anatomical system
GO:0065007 biological regulation
CARO:0000006 material anatomical entity
UBERON:0010000 multicellular anatomical structure
UBERON:0000468 multicellular organism
GO:0009987 cellular process
GO:0003013 circulatory system process
CARO:0000003 connected anatomical structure
UBERON:0000465 material anatomical entity
GO:0003012 muscle system process
UBERON:0000062 organ
UBERON:0011216 organ system subdivision
GO:0050789 regulation of biological process
GO:0050896 response to stimulus
GO:0007154 cell communication
GO:0051716 cellular response to stimulus
UBERON:0001009 circulatory system
UBERON:0003103 compound organ
GO:0007186 G protein-coupled receptor signaling pathway
GO:0032501 multicellular organismal process
UBERON:0002385 muscle tissue
UBERON:0000383 musculature of body
GO:0050794 regulation of cellular process
GO:0023052 signaling
GO:0003008 system process
GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway
GO:0008015 blood circulation
UBERON:0015228 circulatory organ
UBERON:0004120 mesoderm-derived structure
GO:0006936 muscle contraction
UBERON:0001015 musculature
GO:0007165 signal transduction
UBERON:0002036 striated muscle tissue
UBERON:0000479 tissue
UBERON:8600004 visceral muscle tissue
GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway
GO:0071875 adrenergic receptor signaling pathway
GO:0003015 heart process
UBERON:0007100 primary circulatory organ
UBERON:8600006 visceral striated muscle tissue
GO:0071880 adenylate cyclase-activating adrenergic receptor signaling pathway
UBERON:0001133 cardiac muscle tissue
GO:0086103 G protein-coupled receptor signaling pathway involved in heart process
GO:0090075 relaxation of muscle
GO:0086023 adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process
GO:0055119 relaxation of cardiac muscle
GO:0086030 adenylate cyclase-activating adrenergic receptor signaling pathway involved in cardiac muscle relaxation

Parents of adenylate cyclase-activating adrenergic receptor signaling pathway involved in cardiac muscle relaxation (GO:0086030)

subject	relation	object
adenylate cyclase-activating adrenergic receptor signaling pathway involved in cardiac muscle relaxation	BFO:0000050	relaxation of cardiac muscle (GO:0055119)
adenylate cyclase-activating adrenergic receptor signaling pathway involved in cardiac muscle relaxation	is_a	adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process (GO:0086023)

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