AmiGO 2: Term Details for "G protein-coupled acetylcholine receptor signaling pathway involved in negative regulation of heart rate" (GO:0086033)

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Term Information

Accession: GO:0086033
Name: G protein-coupled acetylcholine receptor signaling pathway involved in negative regulation of heart rate
Ontology: biological_process
Synonyms: G-protein coupled acetylcholine receptor signaling pathway involved in negative regulation of heart rate, M2 receptor signalling pathway involved in negative regulation of heart rate, muscarinic acetylcholine receptor signaling pathway involved in negative regulation of heart rate, muscarinic receptor signalling pathway involved in negative regulation of heart rate
Alternate IDs: None
Definition: A G protein-coupled acetylcholine receptor signaling pathway that contributes to a decrease in frequency or rate of heart contraction. Binding of acetylcholine to a G protein-coupled (muscarinic) receptor on the surface of the signal-receiving cell results in the alpha subunit of a coupled G-protein binding to GTP. This results in the separation of the beta-gamma complex from the alpha subunit. Both the alpha subunit, and the beta-gamma complex can continue to signal to bring about membrane hyperpolarization and a reduction in heart rate. Source: GOC:BHF, Wikipedia:G_protein-gated_ion_channel, GOC:mtg_cardiac_conduct_nov11
Comment: None
History: See term history for GO:0086033 at QuickGO
Chem. react.: None
Subset: None
Related: Link to all genes and gene products annotated to G protein-coupled acetylcholine receptor signaling pathway involved in negative regulation of heart rate (excluding "regulates").; Link to all direct and indirect annotations to G protein-coupled acetylcholine receptor signaling pathway involved in negative regulation of heart rate (excluding "regulates").; Link to all direct and indirect annotations download (limited to first 10,000) for G protein-coupled acetylcholine receptor signaling pathway involved in negative regulation of heart rate (excluding "regulates").

Include "regulates"
For more information, please see the ontology relation documentation.

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CARO:0030000 biological entity
CARO:0000000 anatomical entity
UBERON:0001062 anatomical entity
CARO:0000006 material anatomical entity
CARO:0000003 connected anatomical structure
UBERON:0000465 material anatomical entity
UBERON:0000061 anatomical structure
GO:0005575 cellular_component
GO:0110165 cellular anatomical entity
GO:0050896 response to stimulus
GO:0065007 biological regulation
GO:0008150 biological_process
GO:0008015 blood circulation
GO:0007154 cell communication
GO:0030054 cell junction
GO:0051716 cellular response to stimulus
GO:0032501 multicellular organismal process
GO:0050789 regulation of biological process
GO:0065008 regulation of biological quality
GO:0051239 regulation of multicellular organismal process
GO:0042221 response to chemical
GO:0023052 signaling
GO:0003008 system process
GO:0007267 cell-cell signaling
GO:0009987 cellular process
GO:0070887 cellular response to chemical stimulus
GO:0003013 circulatory system process
GO:0048519 negative regulation of biological process
GO:0008217 regulation of blood pressure
GO:0044057 regulation of system process
GO:1901698 response to nitrogen compound
GO:0010033 response to organic substance
GO:1901700 response to oxygen-containing compound
GO:0045202 synapse
GO:1901699 cellular response to nitrogen compound
GO:1901701 cellular response to oxygen-containing compound
GO:0060047 heart contraction
GO:0003015 heart process
GO:0051241 negative regulation of multicellular organismal process
GO:0050877 nervous system process
GO:1903522 regulation of blood circulation
GO:0050794 regulation of cellular process
GO:0003073 regulation of systemic arterial blood pressure
GO:1905144 response to acetylcholine
GO:0007165 signal transduction
GO:0099536 synaptic signaling
GO:1905145 cellular response to acetylcholine
GO:1903523 negative regulation of blood circulation
GO:0001976 nervous system process involved in regulation of systemic arterial blood pressure
GO:0098926 postsynaptic signal transduction
GO:0008016 regulation of heart contraction
GO:0003044 regulation of systemic arterial blood pressure mediated by a chemical signal
GO:0095500 acetylcholine receptor signaling pathway
GO:0007186 G protein-coupled receptor signaling pathway
GO:0045822 negative regulation of heart contraction
GO:0002027 regulation of heart rate
GO:0003070 regulation of systemic arterial blood pressure by neurotransmitter
GO:0007213 G protein-coupled acetylcholine receptor signaling pathway
GO:0086103 G protein-coupled receptor signaling pathway involved in heart process
GO:0010459 negative regulation of heart rate
GO:0003062 regulation of heart rate by chemical signal
GO:0003068 regulation of systemic arterial blood pressure by acetylcholine
GO:0086093 G protein-coupled acetylcholine receptor signaling pathway involved in heart process
GO:0003063 negative regulation of heart rate by acetylcholine
GO:0086033 G protein-coupled acetylcholine receptor signaling pathway involved in negative regulation of heart rate
GO:0086095 positive regulation of IKACh channel activity by G protein-coupled acetylcholine receptor signaling pathway involved in negative regulation of heart rate

Parents of G protein-coupled acetylcholine receptor signaling pathway involved in negative regulation of heart rate (GO:0086033)

subject	relation	object
G protein-coupled acetylcholine receptor signaling pathway involved in negative regulation of heart rate	BFO:0000050	negative regulation of heart rate by acetylcholine (GO:0003063)
G protein-coupled acetylcholine receptor signaling pathway involved in negative regulation of heart rate	is_a	G protein-coupled acetylcholine receptor signaling pathway involved in heart process (GO:0086093)
G protein-coupled acetylcholine receptor signaling pathway involved in negative regulation of heart rate	BFO:0000050	negative regulation of heart rate (GO:0010459)

Children of G protein-coupled acetylcholine receptor signaling pathway involved in negative regulation of heart rate (GO:0086033)

subject	relation	object
positive regulation of IKACh channel activity by G protein-coupled acetylcholine receptor signaling pathway involved in negative regulation of heart rate (GO:0086095)	is_a	G protein-coupled acetylcholine receptor signaling pathway involved in negative regulation of heart rate

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