AmiGO 2: Term Details for "positive regulation of IKACh channel activity by G protein-coupled acetylcholine receptor signaling pathway involved in negative regulation of heart rate" (GO:0086095)

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Term Information

Accession: GO:0086095
Name: positive regulation of IKACh channel activity by G protein-coupled acetylcholine receptor signaling pathway involved in negative regulation of heart rate
Ontology: biological_process
Synonyms: muscarinic receptor signaling pathway involved in activation of IKACH, positive regulation of IKACh channel activity by G-protein coupled acetylcholine receptor signaling, Gbeta/gamma-coupled muscarinic receptor signaling pathway involved in negative regulation of heart rate, cardiac muscarinic receptor signaling via Gbeta/gamma, muscarinic receptor signaling pathway involved in ion channel activation
Alternate IDs: None
Definition: A G protein-coupled acetylcholine receptor signaling pathway that contributes to a decrease in frequency or rate of heart contraction through activation of the IKACh potassium channel. Binding of acetylcholine to a G protein-coupled acetylcholine receptor (muscarinic receptor) on the surface of the signal-receiving cell results in liberation of the G-beta/gamma complex from the alpha subunit. The G-beta/gamma complex binds directly to the inward-rectifying potassium channel IKACh. Once the ion channel is activated, potassium ions (K+) flow out of the cell and cause it to hyperpolarize. In its hyperpolarized state, action potentials cannot be fired as quickly as possible, which slows the heart rate. Source: GOC:BHF, Wikipedia:G_protein-gated_ion_channel, GOC:mtg_cardiac_conduct_nov11
Comment: None
History: See term history for GO:0086095 at QuickGO
Chem. react.: None
Subset: gocheck_do_not_annotate
Related: Link to all genes and gene products annotated to positive regulation of IKACh channel activity by G protein-coupled acetylcholine receptor signaling pathway involved in negative regulation of heart rate (excluding "regulates").; Link to all direct and indirect annotations to positive regulation of IKACh channel activity by G protein-coupled acetylcholine receptor signaling pathway involved in negative regulation of heart rate (excluding "regulates").; Link to all direct and indirect annotations download (limited to first 10,000) for positive regulation of IKACh channel activity by G protein-coupled acetylcholine receptor signaling pathway involved in negative regulation of heart rate (excluding "regulates").

Include "regulates"
For more information, please see the ontology relation documentation.

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CARO:0030000 biological entity
CARO:0000000 anatomical entity
UBERON:0001062 anatomical entity
CARO:0000006 material anatomical entity
GO:0008150 biological_process
CARO:0000003 connected anatomical structure
UBERON:0000465 material anatomical entity
UBERON:0000061 anatomical structure
GO:0005575 cellular_component
GO:0051179 localization
GO:0050789 regulation of biological process
GO:0065007 biological regulation
GO:0110165 cellular anatomical entity
GO:0009987 cellular process
GO:0051234 establishment of localization
GO:0003674 molecular_function
GO:0048518 positive regulation of biological process
GO:0050794 regulation of cellular process
GO:0032879 regulation of localization
GO:0050896 response to stimulus
GO:0055085 transmembrane transport
GO:0022857 transmembrane transporter activity
GO:0006810 transport
GO:0008015 blood circulation
GO:0007154 cell communication
GO:0030054 cell junction
GO:0051716 cellular response to stimulus
GO:0015267 channel activity
GO:0022836 gated channel activity
GO:0098660 inorganic ion transmembrane transport
GO:0015318 inorganic molecular entity transmembrane transporter activity
GO:0030001 metal ion transport
GO:0006812 monoatomic cation transport
GO:0006811 monoatomic ion transport
GO:0032501 multicellular organismal process
GO:0022803 passive transmembrane transporter activity
GO:0048522 positive regulation of cellular process
GO:0051050 positive regulation of transport
GO:0065008 regulation of biological quality
GO:0065009 regulation of molecular function
GO:0043269 regulation of monoatomic ion transport
GO:0051239 regulation of multicellular organismal process
GO:0034762 regulation of transmembrane transport
GO:0051049 regulation of transport
GO:0042221 response to chemical
GO:0023052 signaling
GO:0003008 system process
GO:0005215 transporter activity
GO:0007267 cell-cell signaling
GO:0070887 cellular response to chemical stimulus
GO:0003013 circulatory system process
GO:0098662 inorganic cation transmembrane transport
GO:0022890 inorganic cation transmembrane transporter activity
GO:0098655 monoatomic cation transmembrane transport
GO:0008324 monoatomic cation transmembrane transporter activity
GO:0005216 monoatomic ion channel activity
GO:0034220 monoatomic ion transmembrane transport
GO:0015075 monoatomic ion transmembrane transporter activity
GO:0048519 negative regulation of biological process
GO:0044093 positive regulation of molecular function
GO:0043270 positive regulation of monoatomic ion transport
GO:0034764 positive regulation of transmembrane transport
GO:0006813 potassium ion transport
GO:0008217 regulation of blood pressure
GO:0010959 regulation of metal ion transport
GO:0034765 regulation of monoatomic ion transmembrane transport
GO:0043266 regulation of potassium ion transport
GO:0044057 regulation of system process
GO:0032409 regulation of transporter activity
GO:1901698 response to nitrogen compound
GO:0010033 response to organic substance
GO:1901700 response to oxygen-containing compound
GO:0045202 synapse
GO:0022832 voltage-gated channel activity
GO:1901699 cellular response to nitrogen compound
GO:1901701 cellular response to oxygen-containing compound
GO:0060047 heart contraction
GO:0003015 heart process
GO:0022834 ligand-gated channel activity
GO:0046873 metal ion transmembrane transporter activity
GO:0005261 monoatomic cation channel activity
GO:0051241 negative regulation of multicellular organismal process
GO:0050877 nervous system process
GO:1904064 positive regulation of cation transmembrane transport
GO:0034767 positive regulation of monoatomic ion transmembrane transport
GO:0043268 positive regulation of potassium ion transport
GO:0032411 positive regulation of transporter activity
GO:0071805 potassium ion transmembrane transport
GO:0015079 potassium ion transmembrane transporter activity
GO:1903522 regulation of blood circulation
GO:1904062 regulation of monoatomic cation transmembrane transport
GO:0032412 regulation of monoatomic ion transmembrane transporter activity
GO:1901379 regulation of potassium ion transmembrane transport
GO:0003073 regulation of systemic arterial blood pressure
GO:0022898 regulation of transmembrane transporter activity
GO:1905144 response to acetylcholine
GO:0007165 signal transduction
GO:0099536 synaptic signaling
GO:0005244 voltage-gated monoatomic ion channel activity
GO:1905145 cellular response to acetylcholine
GO:0015276 ligand-gated monoatomic ion channel activity
GO:1903523 negative regulation of blood circulation
GO:0001976 nervous system process involved in regulation of systemic arterial blood pressure
GO:0032414 positive regulation of ion transmembrane transporter activity
GO:1901381 positive regulation of potassium ion transmembrane transport
GO:0098926 postsynaptic signal transduction
GO:0005267 potassium channel activity
GO:2001257 regulation of cation channel activity
GO:0008016 regulation of heart contraction
GO:1901016 regulation of potassium ion transmembrane transporter activity
GO:0003044 regulation of systemic arterial blood pressure mediated by a chemical signal
GO:0022843 voltage-gated monoatomic cation channel activity
GO:0095500 acetylcholine receptor signaling pathway
GO:0007186 G protein-coupled receptor signaling pathway
GO:0005242 inward rectifier potassium channel activity
GO:0099094 ligand-gated monoatomic cation channel activity
GO:0045822 negative regulation of heart contraction
GO:2001259 positive regulation of cation channel activity
GO:1901018 positive regulation of potassium ion transmembrane transporter activity
GO:0002027 regulation of heart rate
GO:0003070 regulation of systemic arterial blood pressure by neurotransmitter
GO:0005249 voltage-gated potassium channel activity
GO:0007213 G protein-coupled acetylcholine receptor signaling pathway
GO:0086103 G protein-coupled receptor signaling pathway involved in heart process
GO:0015467 G-protein activated inward rectifier potassium channel activity
GO:0010459 negative regulation of heart rate
GO:1903818 positive regulation of voltage-gated potassium channel activity
GO:0003062 regulation of heart rate by chemical signal
GO:1901979 regulation of inward rectifier potassium channel activity
GO:0003068 regulation of systemic arterial blood pressure by acetylcholine
GO:0086093 G protein-coupled acetylcholine receptor signaling pathway involved in heart process
GO:0003063 negative regulation of heart rate by acetylcholine
GO:1901980 positive regulation of inward rectifier potassium channel activity
GO:1900128 regulation of G-protein activated inward rectifier potassium channel activity
GO:0086033 G protein-coupled acetylcholine receptor signaling pathway involved in negative regulation of heart rate
GO:1900129 positive regulation of G-protein activated inward rectifier potassium channel activity
GO:0086095 positive regulation of IKACh channel activity by G protein-coupled acetylcholine receptor signaling pathway involved in negative regulation of heart rate

Parents of positive regulation of IKACh channel activity by G protein-coupled acetylcholine receptor signaling pathway involved in negative regulation of heart rate (GO:0086095)

subject	relation	object
positive regulation of IKACh channel activity by G protein-coupled acetylcholine receptor signaling pathway involved in negative regulation of heart rate	is_a	G protein-coupled acetylcholine receptor signaling pathway involved in negative regulation of heart rate (GO:0086033)
positive regulation of IKACh channel activity by G protein-coupled acetylcholine receptor signaling pathway involved in negative regulation of heart rate	is_a	positive regulation of G-protein activated inward rectifier potassium channel activity (GO:1900129)
positive regulation of IKACh channel activity by G protein-coupled acetylcholine receptor signaling pathway involved in negative regulation of heart rate	RO:0002213	G-protein activated inward rectifier potassium channel activity (GO:0015467)

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