AmiGO 2: Term Details for "apoptotic signaling pathway" (GO:0097190)

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Term Information

Accession: GO:0097190
Name: apoptotic signaling pathway
Ontology: biological_process
Synonyms: apoptotic signalling pathway, induction of apoptosis by extracellular signals
Alternate IDs: GO:0008624
Definition: The series of molecular signals which triggers the apoptotic death of a cell. The pathway starts with reception of a signal, and ends when the execution phase of apoptosis is triggered. Source: GOC:mtg_apoptosis
Comment: This term can be used to annotate gene products involved in apoptotic events happening downstream of the cross-talk point between the extrinsic and intrinsic apoptotic pathways. The cross-talk starts when caspase-8 cleaves Bid and truncated Bid interacts with mitochondria. From this point on it is not possible to distinguish between extrinsic and intrinsic pathways.
History: See term history for GO:0097190 at QuickGO
Chem. react.: None
Subset: None
Related: Link to all genes and gene products annotated to apoptotic signaling pathway (excluding "regulates").; Link to all direct and indirect annotations to apoptotic signaling pathway (excluding "regulates").; Link to all direct and indirect annotations download (limited to first 10,000) for apoptotic signaling pathway (excluding "regulates").

Include "regulates"
For more information, please see the ontology relation documentation.

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GO:0008150 biological_process
GO:0065007 biological regulation
GO:0009987 cellular process
GO:0008219 cell death
GO:0050789 regulation of biological process
GO:0050896 response to stimulus
GO:0007154 cell communication
GO:0051716 cellular response to stimulus
GO:0012501 programmed cell death
GO:0050794 regulation of cellular process
GO:0023052 signaling
GO:0006915 apoptotic process
GO:0007165 signal transduction
GO:0097190 apoptotic signaling pathway
GO:0097314 apoptosome assembly
GO:0097191 extrinsic apoptotic signaling pathway
GO:0008626 granzyme-mediated apoptotic signaling pathway
GO:0008628 hormone-mediated apoptotic signaling pathway
GO:0097193 intrinsic apoptotic signaling pathway
GO:0097345 mitochondrial outer membrane permeabilization
GO:2001234 negative regulation of apoptotic signaling pathway
GO:2001235 positive regulation of apoptotic signaling pathway
GO:2001233 regulation of apoptotic signaling pathway
GO:0001836 release of cytochrome c from mitochondria

Parents of apoptotic signaling pathway (GO:0097190)

subject	relation	object
apoptotic signaling pathway	BFO:0000050	apoptotic process (GO:0006915)
apoptotic signaling pathway	RO:0002162	Opisthokonta (NCBITaxon:33154)
apoptotic signaling pathway	is_a	signal transduction (GO:0007165)

Children of apoptotic signaling pathway (GO:0097190)

subject	relation	object
negative regulation of apoptotic signaling pathway (GO:2001234)	RO:0002212	apoptotic signaling pathway
release of cytochrome c from mitochondria (GO:0001836)	BFO:0000050	apoptotic signaling pathway
regulation of apoptotic signaling pathway (GO:2001233)	RO:0002211	apoptotic signaling pathway
mitochondrial outer membrane permeabilization (GO:0097345)	BFO:0000050	apoptotic signaling pathway
intrinsic apoptotic signaling pathway (GO:0097193)	is_a	apoptotic signaling pathway
extrinsic apoptotic signaling pathway (GO:0097191)	is_a	apoptotic signaling pathway
apoptosome assembly (GO:0097314)	BFO:0000050	apoptotic signaling pathway
granzyme-mediated apoptotic signaling pathway (GO:0008626)	is_a	apoptotic signaling pathway
apoptotic process (GO:0006915)	RO:0002224	apoptotic signaling pathway
positive regulation of apoptotic signaling pathway (GO:2001235)	RO:0002213	apoptotic signaling pathway
hormone-mediated apoptotic signaling pathway (GO:0008628)	is_a	apoptotic signaling pathway

Reactome: R-HSA-75157; R-HSA-204998; R-HSA-193681