AmiGO 2: Term Details for "extrinsic apoptotic signaling pathway in absence of ligand" (GO:0097192)

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Term Information

Accession: GO:0097192
Name: extrinsic apoptotic signaling pathway in absence of ligand
Ontology: biological_process
Synonyms: extrinsic apoptotic signalling pathway in absence of ligand, dependence receptor signaling pathway, extrinsic apoptosis in absence of ligand
Alternate IDs: None
Definition: The series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with withdrawal of a ligand from a cell surface receptor, and ends when the execution phase of apoptosis is triggered. Source: PMID:20816705, PMID:15044679, GOC:mtg_apoptosis
Comment: For dependence receptors, absence of a ligand or withdrawal of a ligand from a receptor acts as a signal. An example of 'extrinsic apoptotic signaling pathway in absence of ligand' is withdrawal of a growth factor such as NGF, even if traditionally apoptosis induced via growth factor withdrawal has been classified as an instance of intrinsic apoptosis. See an example in PMID:19767770. Ligands whose withdrawal or absence induce apoptosis should be annotated to GO:2001239 'regulation of extrinsic apoptotic signaling pathway in absence of ligand', rather than to the pathway term itself. Examples of gene products that may be annotated to GO:0097192 'extrinsic apoptotic signaling pathway in absence of ligand' include dependence receptors such as DCC or UNC5B, which relay lethal signals in the absence of their ligand (netrin-1). In the case of DCC and UNC5B, the signaling proceeds through the assembly of a DRAL- and TUCAN- (or NLRP1-) containing caspase-9-activating complex or by the dephosphorylation-mediated activation of death-associated protein kinase 1 (DAPK1) by UNC5B-bound protein phosphatase 2A (PP2A), respectively. DAPK1 can mediate the direct activation of executioner caspases or favor MOMP (reviewed in PMID:21760595). Also see PMID:21172653 (annotations to UNC5B and PR65beta, UniProt symbols O08722, PPP2R1B and P30154).
History: See term history for GO:0097192 at QuickGO
Chem. react.: None
Subset: None
Related: Link to all genes and gene products annotated to extrinsic apoptotic signaling pathway in absence of ligand (excluding "regulates").; Link to all direct and indirect annotations to extrinsic apoptotic signaling pathway in absence of ligand (excluding "regulates").; Link to all direct and indirect annotations download (limited to first 10,000) for extrinsic apoptotic signaling pathway in absence of ligand (excluding "regulates").

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For more information, please see the ontology relation documentation.

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GO:0008150 biological_process
GO:0009987 cellular process
GO:0065007 biological regulation
GO:0008219 cell death
GO:0012501 programmed cell death
GO:0050789 regulation of biological process
GO:0050896 response to stimulus
GO:0006915 apoptotic process
GO:0007154 cell communication
GO:0051716 cellular response to stimulus
GO:0050794 regulation of cellular process
GO:0007165 signal transduction
GO:0023052 signaling
GO:0097190 apoptotic signaling pathway
GO:0007166 cell surface receptor signaling pathway
GO:0097191 extrinsic apoptotic signaling pathway
GO:0038034 signal transduction in absence of ligand
GO:0097192 extrinsic apoptotic signaling pathway in absence of ligand
GO:2001240 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
GO:2001241 positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
GO:2001239 regulation of extrinsic apoptotic signaling pathway in absence of ligand

Parents of extrinsic apoptotic signaling pathway in absence of ligand (GO:0097192)

subject	relation	object
extrinsic apoptotic signaling pathway in absence of ligand	is_a	signal transduction in absence of ligand (GO:0038034)
extrinsic apoptotic signaling pathway in absence of ligand	is_a	extrinsic apoptotic signaling pathway (GO:0097191)

Children of extrinsic apoptotic signaling pathway in absence of ligand (GO:0097192)

subject	relation	object
regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001239)	RO:0002211	extrinsic apoptotic signaling pathway in absence of ligand
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001240)	RO:0002212	extrinsic apoptotic signaling pathway in absence of ligand
positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)	RO:0002213	extrinsic apoptotic signaling pathway in absence of ligand

extrinsic apoptotic signaling pathway in absence of ligand