AmiGO 2: Term Details for "intrinsic apoptotic signaling pathway" (GO:0097193)

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Term Information

Accession: GO:0097193
Name: intrinsic apoptotic signaling pathway
Ontology: biological_process
Synonyms: intrinsic apoptotic pathway, intrinsic apoptotic signalling pathway, mitochondrial-mediated apoptotic pathway, induction of apoptosis by intracellular signals, intrinsic apoptosis
Alternate IDs: GO:0008629
Definition: The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway starts with reception of an intracellular signal (e.g. DNA damage, endoplasmic reticulum stress, oxidative stress etc.), and ends when the execution phase of apoptosis is triggered. The intrinsic apoptotic signaling pathway is crucially regulated by permeabilization of the mitochondrial outer membrane (MOMP). Source: PMID:11919192, PMID:18852119, GOC:yaf, GOC:mtg_apoptosis, PMID:17340152
Comment: The signals that start intrinsic apoptosis may come from extracellular sources (e.g. oxidative stress, UV exposure), but the reception of the signal and thus the signaling pathway start inside the cell (as a result of DNA damage, redox imbalance, etc.). Examples are ZPR9 (ZNF622) and ASK1 (MAP3K5) (UniProt symbols Q969S3 and Q99683) in PMID:21771788. A diagram of the intrinsic apoptotic pathway including examples of molecular players can be found in Figure 2 in PMID:21760595.
History: See term history for GO:0097193 at QuickGO
Chem. react.: None
Subset: None
Related: Link to all genes and gene products annotated to intrinsic apoptotic signaling pathway (excluding "regulates").; Link to all direct and indirect annotations to intrinsic apoptotic signaling pathway (excluding "regulates").; Link to all direct and indirect annotations download (limited to first 10,000) for intrinsic apoptotic signaling pathway (excluding "regulates").

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For more information, please see the ontology relation documentation.

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CARO:0030000 biological entity
CARO:0000000 anatomical entity
UBERON:0001062 anatomical entity
GO:0008150 biological_process
CARO:0000006 material anatomical entity
GO:0065007 biological regulation
GO:0009987 cellular process
CARO:0000003 connected anatomical structure
UBERON:0000465 material anatomical entity
UBERON:0000061 anatomical structure
GO:0008219 cell death
GO:0005575 cellular_component
GO:0050789 regulation of biological process
GO:0050896 response to stimulus
CL:0000000 cell
GO:0007154 cell communication
GO:0110165 cellular anatomical structure
GO:0051716 cellular response to stimulus
GO:0012501 programmed cell death
GO:0050794 regulation of cellular process
GO:0023052 signaling
GO:0006915 apoptotic process
GO:0005622 intracellular anatomical structure
GO:0007165 signal transduction
GO:0097190 apoptotic signaling pathway
GO:0035556 intracellular signal transduction
GO:0097193 intrinsic apoptotic signaling pathway
GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator
GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage
GO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:1990144 intrinsic apoptotic signaling pathway in response to hypoxia
GO:1990442 intrinsic apoptotic signaling pathway in response to nitrosative stress
GO:0008627 intrinsic apoptotic signaling pathway in response to osmotic stress
GO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress
GO:2001243 negative regulation of intrinsic apoptotic signaling pathway
GO:2001244 positive regulation of intrinsic apoptotic signaling pathway
GO:2001242 regulation of intrinsic apoptotic signaling pathway

Parents of intrinsic apoptotic signaling pathway (GO:0097193)

subject	relation	object
intrinsic apoptotic signaling pathway	is_a	apoptotic signaling pathway (GO:0097190)
intrinsic apoptotic signaling pathway	RO:0002162	Opisthokonta (NCBITaxon:33154)
intrinsic apoptotic signaling pathway	is_a	intracellular signal transduction (GO:0035556)

Children of intrinsic apoptotic signaling pathway (GO:0097193)

subject	relation	object
intrinsic apoptotic signaling pathway in response to hypoxia (GO:1990144)	is_a	intrinsic apoptotic signaling pathway
negative regulation of intrinsic apoptotic signaling pathway (GO:2001243)	RO:0002212	intrinsic apoptotic signaling pathway
intrinsic apoptotic signaling pathway in response to DNA damage (GO:0008630)	is_a	intrinsic apoptotic signaling pathway
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059)	is_a	intrinsic apoptotic signaling pathway
intrinsic apoptotic signaling pathway by p53 class mediator (GO:0072332)	is_a	intrinsic apoptotic signaling pathway
intrinsic apoptotic signaling pathway in response to nitrosative stress (GO:1990442)	is_a	intrinsic apoptotic signaling pathway
regulation of intrinsic apoptotic signaling pathway (GO:2001242)	RO:0002211	intrinsic apoptotic signaling pathway
positive regulation of intrinsic apoptotic signaling pathway (GO:2001244)	RO:0002213	intrinsic apoptotic signaling pathway
intrinsic apoptotic signaling pathway in response to oxidative stress (GO:0008631)	is_a	intrinsic apoptotic signaling pathway
intrinsic apoptotic signaling pathway in response to osmotic stress (GO:0008627)	is_a	intrinsic apoptotic signaling pathway

Reactome: R-HSA-109606