AmiGO 2: Term Details for "cysteine-type endopeptidase activity involved in apoptotic signaling pathway" (GO:0097199)

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Term Information

Accession: GO:0097199
Name: cysteine-type endopeptidase activity involved in apoptotic signaling pathway
Ontology: molecular_function
Synonyms: cysteine-type endopeptidase activity involved in apoptotic signalling pathway, activator caspase activity, apical caspase activity, initiator caspase activity
Alternate IDs: None
Definition: Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile, and contributing to the apoptotic signaling pathway. Source: PMID:11717445, Wikipedia:Caspase, GOC:mtg_apoptosis
Comment: Examples of gene products that may be annotated to this term include CASP2, CASP8, CASP9, and CASP10, also called initiator (or apical, or activator) caspases.
History: See term history for GO:0097199 at QuickGO
Chem. react.: None
Subset: None
Related: Link to all genes and gene products annotated to cysteine-type endopeptidase activity involved in apoptotic signaling pathway (excluding "regulates").; Link to all direct and indirect annotations to cysteine-type endopeptidase activity involved in apoptotic signaling pathway (excluding "regulates").; Link to all direct and indirect annotations download (limited to first 10,000) for cysteine-type endopeptidase activity involved in apoptotic signaling pathway (excluding "regulates").

Include "regulates"
For more information, please see the ontology relation documentation.

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GO:0003674 molecular_function
GO:0008150 biological_process
GO:0003824 catalytic activity
GO:0065007 biological regulation
GO:0140096 catalytic activity, acting on a protein
GO:0009987 cellular process
GO:0016787 hydrolase activity
GO:0008219 cell death
GO:0008233 peptidase activity
GO:0050789 regulation of biological process
GO:0050896 response to stimulus
GO:0007154 cell communication
GO:0051716 cellular response to stimulus
GO:0008234 cysteine-type peptidase activity
GO:0004175 endopeptidase activity
GO:0012501 programmed cell death
GO:0050794 regulation of cellular process
GO:0023052 signaling
GO:0006915 apoptotic process
GO:0004197 cysteine-type endopeptidase activity
GO:0007165 signal transduction
GO:0097190 apoptotic signaling pathway
GO:0097153 cysteine-type endopeptidase activity involved in apoptotic process
GO:0097199 cysteine-type endopeptidase activity involved in apoptotic signaling pathway
GO:2001268 negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
GO:2001269 positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
GO:2001267 regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway

Parents of cysteine-type endopeptidase activity involved in apoptotic signaling pathway (GO:0097199)

subject	relation	object
cysteine-type endopeptidase activity involved in apoptotic signaling pathway	BFO:0000050	apoptotic signaling pathway (GO:0097190)
cysteine-type endopeptidase activity involved in apoptotic signaling pathway	is_a	cysteine-type endopeptidase activity involved in apoptotic process (GO:0097153)

Children of cysteine-type endopeptidase activity involved in apoptotic signaling pathway (GO:0097199)

subject	relation	object
negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway (GO:2001268)	RO:0002212	cysteine-type endopeptidase activity involved in apoptotic signaling pathway
positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway (GO:2001269)	RO:0002213	cysteine-type endopeptidase activity involved in apoptotic signaling pathway
regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway (GO:2001267)	RO:0002211	cysteine-type endopeptidase activity involved in apoptotic signaling pathway

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