obsolete activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
Ontology
biological_process
Synonyms
activation of cysteine-type endopeptidase activity involved in apoptotic signalling pathway, activation of initiator caspase activity
Alternate IDs
None
Definition
OBSOLETE. Any process that initiates the activity of an inactive cysteine-type endopeptidase involved in the apoptotic signaling pathway.
Source:
GOC:mtg_apoptosis
Comment
Components of the DISC (death-inducing signaling complex) may be annotated to this term. These include ligand-bound receptors such as FAS/CD95 (though care should be taken because FAS can also act as a non-apoptotic signal transducer), and signaling molecules such as FADD (FAS-associated protein with a death domain), cIAPs (cellular inhibitor of apoptosis proteins), c-FLIPs and caspases 8 and 10. Note that GO:0097296 should only be used to annotate gene products directly involved in the initiation or start up of an inactive cysteine-type endopeptidase activity involved in the apoptotic signaling pathway (also known as an initiator caspase). If the evidence provided is not sufficient to account for direct activation of this enzymatic activity, consider using the more generic terms GO:2001269 positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway or GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process.
The reason for obsoletion is that this term represents a GO-CAM model.
Link
to all genes and gene products annotated to obsolete activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway (excluding "regulates").
Link
to all direct and indirect annotations
to obsolete activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway (excluding "regulates").
Link
to all direct and indirect annotations download (limited to first 10,000)
for obsolete activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway (excluding "regulates").
