AmiGO 2: Term Details for "ripoptosome" (GO:0097342)

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Term Information

Accession: GO:0097342
Name: ripoptosome
Ontology: cellular_component
Synonyms: necrosome, TNFR1 complex II, Tnfr1-CII
Alternate IDs: None
Definition: A protein complex whose core components are the receptor-interacting serine/threonine-protein kinases RIPK1 and RIPK3 (also called RIP1 and RIP3). Formation of the ripoptosome can induce an extrinsic apoptotic signaling pathway or a necroptotic signaling pathway. The composition of this protein complex may depend on several factors including nature of the signal, cell type and more. Source: GOC:mtg_apoptosis, PMID:22274400, GOC:bhm, PMID:22265414
Comment: It has been shown that receptor-mediated necroptotic signaling pathway requires assembly of a ripoptosome protein complex consisting of caspase-8, caspase-10, Fas-associated death domain protein (FADD), casp8 and FADD-like apoptosis regulator (CFLAR) as well as the two receptor-interacting serine/threonine-protein kinases RIPK1 and RIPK3 (PMID:21737330). Optionally, depending on the receptor activated, this complex may contain TLR3 adaptor protein TRIF (PMID:21737330).
History: See term history for GO:0097342 at QuickGO
Chem. react.: None
Subset: None
Related: Link to all genes and gene products annotated to ripoptosome (excluding "regulates").; Link to all direct and indirect annotations to ripoptosome (excluding "regulates").; Link to all direct and indirect annotations download (limited to first 10,000) for ripoptosome (excluding "regulates").