AmiGO 2: Term Details for "neurofibrillary tangle" (GO:0097418)

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Term Information

Accession: GO:0097418
Name: neurofibrillary tangle
Ontology: cellular_component
Synonyms: flame-shaped neurofibrillary tangle, star-shaped neurofibrillary tangle
Alternate IDs: None
Definition: Intracellular mass of paired, helically wound protein filaments (also called PHF) lying in the cytoplasm of neuronal cell bodies and neuritic cell processes. Neurofibrillary tangles contain an abnormally phosphorylated form of a microtubule-associated protein, tau. The shape of these inclusions may resemble a flame or a star. Source: NIF_Subcellular:sao2409833926, NIF_Subcellular:nlx_subcell_20090202, NIF_Subcellular:nlx_subcell_20090201
Comment: Neurofibrillary tangles have been found in aging population; their formation is increased in Alzheimer's disease patients (and in other neurological diseases) compared to normal controls (see PMID:848276 and PMID:8584267).
History: See term history for GO:0097418 at QuickGO
Chem. react.: None
Subset: None
Related: Link to all genes and gene products annotated to neurofibrillary tangle (excluding "regulates").; Link to all direct and indirect annotations to neurofibrillary tangle (excluding "regulates").; Link to all direct and indirect annotations download (limited to first 10,000) for neurofibrillary tangle (excluding "regulates").

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For more information, please see the ontology relation documentation.

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CARO:0030000 biological entity
CARO:0000000 anatomical entity
UBERON:0000061 anatomical structure
UBERON:0001062 anatomical entity
GO:0008150 biological_process
CARO:0000006 material anatomical entity
UBERON:0010000 multicellular anatomical structure
CARO:0000003 connected anatomical structure
UBERON:0000465 material anatomical entity
UBERON:0000468 multicellular organism
GO:0032501 multicellular organismal process
UBERON:0000467 anatomical system
CL:0000000 cell
GO:0009987 cellular process
GO:0005575 cellular_component
GO:0050877 nervous system process
GO:0003008 system process
GO:0007154 cell communication
GO:0110165 cellular anatomical entity
CL:0000211 electrically active cell
UBERON:0001016 nervous system
CL:0000393 electrically responsive cell
CL:0000404 electrically signaling cell
GO:0005622 intracellular anatomical structure
CL:0002319 neural cell
GO:0019226 transmission of nerve impulse
GO:0016234 inclusion body
CL:0000540 neuron
GO:0097418 neurofibrillary tangle

Parents of neurofibrillary tangle (GO:0097418)

subject	relation	object
neurofibrillary tangle	RO:0002160	Metazoa (NCBITaxon:33208)
neurofibrillary tangle	is_a	inclusion body (GO:0016234)
neurofibrillary tangle	RO:0002162	Eumetazoa (NCBITaxon:6072)
neurofibrillary tangle	BFO:0000050	neuron (CL:0000540)

This term has no children.

NIF_Subcellular: sao2409833926; nlx_subcell_20090202; nlx_subcell_20090201