AmiGO 2: Term Details for "GAIT complex" (GO:0097452)

Accession: GO:0097452
Name: GAIT complex
Ontology: cellular_component
Synonyms: IFN-gamma-activated inhibitor of translation complex, gamma interferon-activated inhibitor of translation complex
Alternate IDs: None
Definition: A protein complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. The complex binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs and suppresses their translation by blocking the recruitment of the 43S ribosomal complex to m7G cap-bound eIF4G. In humans it includes RPL13A, EPRS, SYNCRIP and GAPDH; mouse complexes lack SYNCRIP. Source: PMID:15479637, GOC:br, PMID:23071094
Comment: None
History: See term history for GO:0097452 at QuickGO
Chem. react.: None
Subset: None
Related: Link to all genes and gene products annotated to GAIT complex (excluding "regulates").; Link to all direct and indirect annotations to GAIT complex (excluding "regulates").; Link to all direct and indirect annotations download (limited to first 10,000) for GAIT complex (excluding "regulates").

Include "regulates"
For more information, please see the ontology relation documentation.

subject	relation	object
GAIT complex	is_a	protein-containing complex (GO:0032991)

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