AmiGO 2: Term Details for "calcineurin-mediated signaling" (GO:0097720)

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Term Information

Accession: GO:0097720
Name: calcineurin-mediated signaling
Ontology: biological_process
Synonyms: calcineurin-mediated signalling, calcineurin signaling
Alternate IDs: None
Definition: Any intracellular signal transduction in which the signal is passed on within the cell by activation of a transcription factor as a consequence of dephosphorylation by Ca(2+)-activated calcineurin. The process begins with calcium-dependent activation of the phosphatase calcineurin. Calcineurin is a calcium- and calmodulin-dependent serine/threonine protein phosphatase with a conserved function in eukaryotic species from yeast to humans. In yeast and fungi, calcineurin regulates stress signaling and cell cycle, and sporulation and virulence in pathogenic fungi. In metazoans, calcineurin is involved in cell commitment, organogenesis and organ development and immune function of T-lymphocytes. By a conserved mechanism, calcineurin phosphatase activates fungal Crz1 and mammalian NFATc by dephosphorylation and translocation of these transcription factors to the nucleus to regulate gene expression. Source: PMID:25655284, GOC:di, PMID:26851544, PMID:25878052
Comment: None
History: See term history for GO:0097720 at QuickGO
Chem. react.: None
Subset: None
Related: Link to all genes and gene products annotated to calcineurin-mediated signaling (excluding "regulates").; Link to all direct and indirect annotations to calcineurin-mediated signaling (excluding "regulates").; Link to all direct and indirect annotations download (limited to first 10,000) for calcineurin-mediated signaling (excluding "regulates").

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CARO:0030000 biological entity
CARO:0000000 anatomical entity
UBERON:0001062 anatomical entity
GO:0008150 biological_process
CARO:0000006 material anatomical entity
GO:0065007 biological regulation
CARO:0000003 connected anatomical structure
UBERON:0000465 material anatomical entity
UBERON:0000061 anatomical structure
GO:0009987 cellular process
GO:0005575 cellular_component
GO:0050789 regulation of biological process
GO:0050896 response to stimulus
CL:0000000 cell
GO:0007154 cell communication
GO:0110165 cellular anatomical entity
GO:0051716 cellular response to stimulus
GO:0050794 regulation of cellular process
GO:0023052 signaling
GO:0005622 intracellular anatomical structure
GO:0007165 signal transduction
GO:0035556 intracellular signal transduction
GO:0141124 intracellular signaling cassette
GO:0019722 calcium-mediated signaling
GO:0097720 calcineurin-mediated signaling
GO:0033173 calcineurin-NFAT signaling cascade
GO:0106057 negative regulation of calcineurin-mediated signaling
GO:0106058 positive regulation of calcineurin-mediated signaling
GO:0106056 regulation of calcineurin-mediated signaling

Parents of calcineurin-mediated signaling (GO:0097720)

subject	relation	object
calcineurin-mediated signaling	is_a	calcium-mediated signaling (GO:0019722)

Children of calcineurin-mediated signaling (GO:0097720)

subject	relation	object
positive regulation of calcineurin-mediated signaling (GO:0106058)	RO:0002213	calcineurin-mediated signaling
negative regulation of calcineurin-mediated signaling (GO:0106057)	RO:0002212	calcineurin-mediated signaling
regulation of calcineurin-mediated signaling (GO:0106056)	RO:0002211	calcineurin-mediated signaling
calcineurin-NFAT signaling cascade (GO:0033173)	is_a	calcineurin-mediated signaling

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