AmiGO 2: Term Details for "transforming growth factor beta complex" (GO:0099126)

Notice

Some functionality on this page depends on JavaScript. To fully use the features of AmiGO 2, enable JavaScript in your browser and reload from the landing page.

Term Information

Accession: GO:0099126
Name: transforming growth factor beta complex
Ontology: cellular_component
Synonyms: TGF-beta complex, TGF-beta dimer, TGFB complex, TGFB dimer, TGFbeta complex, TGFbeta dimer
Alternate IDs: None
Definition: A protein complex acting as ligand of the transforming growth factor beta receptor complex, typically a homodimer of any of the TFGbeta isoforms. The precursor of TGFbeta proteins is cleaved into mature TGFbeta and the latency-associated peptide (LAP), which remains non-covalently linked to mature TGFbeta rendering it inactive. TGFbeta is activated by dimerization and dissociation of the LAP. Source: PMID:22943793, GOC:bhm
Comment: None
History: See term history for GO:0099126 at QuickGO
Chem. react.: None
Subset: None
Related: Link to all genes and gene products annotated to transforming growth factor beta complex (excluding "regulates").; Link to all direct and indirect annotations to transforming growth factor beta complex (excluding "regulates").; Link to all direct and indirect annotations download (limited to first 10,000) for transforming growth factor beta complex (excluding "regulates").

Include "regulates"
For more information, please see the ontology relation documentation.

Filter results

View this term in QuickGO.

Additional external viewing options

OLSVis (interactive)

Additional internal viewing options

GO:0008150 biological_process
CARO:0030000 biological entity
GO:0065007 biological regulation
CARO:0000000 anatomical entity
GO:0009987 cellular process
GO:0050789 regulation of biological process
GO:0050896 response to stimulus
UBERON:0001062 anatomical entity
GO:0007154 cell communication
GO:0051716 cellular response to stimulus
CARO:0000006 material anatomical entity
GO:0050794 regulation of cellular process
GO:0023052 signaling
CARO:0000003 connected anatomical structure
UBERON:0000465 material anatomical entity
GO:0003674 molecular_function
GO:0007165 signal transduction
UBERON:0000061 anatomical structure
GO:0005488 binding
GO:0007166 cell surface receptor signaling pathway
GO:0110165 cellular anatomical entity
GO:0005575 cellular_component
GO:0009719 response to endogenous stimulus
CL:0000000 cell
GO:0071944 cell periphery
GO:0071495 cellular response to endogenous stimulus
GO:0007167 enzyme-linked receptor protein signaling pathway
GO:0005515 protein binding
GO:0070848 response to growth factor
GO:0007178 cell surface receptor protein serine/threonine kinase signaling pathway
GO:0071363 cellular response to growth factor stimulus
GO:0030312 external encapsulating structure
GO:0071559 response to transforming growth factor beta
GO:0005102 signaling receptor binding
GO:0071560 cellular response to transforming growth factor beta stimulus
GO:0005126 cytokine receptor binding
GO:0031012 extracellular matrix
PR:000050567 protein-containing material entity
GO:0141091 transforming growth factor beta receptor superfamily signaling pathway
GO:0062023 collagen-containing extracellular matrix
GO:0032991 protein-containing complex
GO:0005160 transforming growth factor beta receptor binding
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0099126 transforming growth factor beta complex

Parents of transforming growth factor beta complex (GO:0099126)

subject	relation	object
transforming growth factor beta complex	RO:0002216	transforming growth factor beta receptor signaling pathway (GO:0007179)
transforming growth factor beta complex	RO:0002162	Metazoa (NCBITaxon:33208)
transforming growth factor beta complex	is_a	protein-containing complex (GO:0032991)
transforming growth factor beta complex	BFO:0000050	collagen-containing extracellular matrix (GO:0062023)
transforming growth factor beta complex	RO:0002215	transforming growth factor beta receptor binding (GO:0005160)

This term has no children.

GONUTS Add usage comments for this term on the GONUTS wiki.