AmiGO 2: Term Details for "deubiquitinase activity" (GO:0101005)

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Term Information

Accession: GO:0101005
Name: deubiquitinase activity
Ontology: molecular_function
Synonyms: ubiquitinyl hydrolase activity
Alternate IDs: GO:1904265
Definition: An isopeptidase activity that cleaves ubiquitin from a target protein to which it is conjugated. Source: GOC:mec, PMID:30783221
Comment: There are two main classes of deubiquitinating enzymes: cysteine proteases (i.e., thiol dependent) and metalloproteases.
History: See term history for GO:0101005 at QuickGO
Chem. react.: None
Subset: None
Related: Link to all genes and gene products annotated to deubiquitinase activity (excluding "regulates").; Link to all direct and indirect annotations to deubiquitinase activity (excluding "regulates").; Link to all direct and indirect annotations download (limited to first 10,000) for deubiquitinase activity (excluding "regulates").

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For more information, please see the ontology relation documentation.

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Additional internal viewing options

GO:0003674 molecular_function
GO:0003824 catalytic activity
GO:0140096 catalytic activity, acting on a protein
GO:0016787 hydrolase activity
GO:0008233 peptidase activity
GO:0019783 ubiquitin-like protein peptidase activity
GO:0101005 deubiquitinase activity
GO:0004843 cysteine-type deubiquitinase activity
GO:0140934 histone deubiquitinase activity
GO:0180017 K11-linked deubiquitinase activity
GO:1990380 K48-linked deubiquitinase activity
GO:0061578 K63-linked deubiquitinase activity
GO:0140492 metal-dependent deubiquitinase activity

Parents of deubiquitinase activity (GO:0101005)

subject	relation	object
deubiquitinase activity	is_a	ubiquitin-like protein peptidase activity (GO:0019783)

Children of deubiquitinase activity (GO:0101005)

subject	relation	object
deubiquitinase activator activity (GO:0035800)	RO:0002629	deubiquitinase activity
metal-dependent deubiquitinase activity (GO:0140492)	is_a	deubiquitinase activity
K63-linked deubiquitinase activity (GO:0061578)	is_a	deubiquitinase activity
K48-linked deubiquitinase activity (GO:1990380)	is_a	deubiquitinase activity
K11-linked deubiquitinase activity (GO:0180017)	is_a	deubiquitinase activity
cysteine-type deubiquitinase activity (GO:0004843)	is_a	deubiquitinase activity
histone deubiquitinase activity (GO:0140934)	is_a	deubiquitinase activity

Reactome: R-HSA-9674127