Term Information

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Accession
GO:0110016
Name
B-WICH complex
Ontology
cellular_component
Synonyms
None
Alternate IDs
None
Definition
A chromatin remodeling complex that positively regulates histone H3 acetylation, in particular H3K9, by recruiting histone acetyltransferases to rDNA gene regions. Located in the nucleolus where it assembles on RNA Polymerase I (Pol I) and possibly on RNA Polymerase III (Pol III) promoter and coding regions during early G1 phase and activates the post-initiation phases of Pol I transcription. May also activate RNA Polymerase II (Pol II) gene transcription. In mammals, B-WICH contains the WICH complex core of BAZ1B and SMARCA5, additional protein subunits and possibly rRNAs. Although it contains several catalytic subunits it is not clear which functions are carried out by the complex itself. Source: PMID:21559432, PMID:16603771, PMID:26044184, PMID:23555303, GOC:bhm
Comment
An example is BAZ1B (Q9UIG0) in human in PMID:16603771 (by IPI).
History
See term history for GO:0110016 at QuickGO
Chem. react.
None
Subset
None
Include "regulates"
For more information, please see the ontology relation documentation.

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Graph of GO:0110016 from QuickGO

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Parents of B-WICH complex (GO:0110016)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
B-WICH complex [RO:0002215 relation] RO:0002215  euchromatin binding (GO:1990188)
B-WICH complex [RO:0002216 relation] RO:0002216  positive regulation of transcription by RNA polymerase II (GO:0045944)
B-WICH complex [RO:0002216 relation] RO:0002216  positive regulation of transcription by RNA polymerase III (GO:0045945)
B-WICH complex [RO:0002216 relation] RO:0002216  chromatin remodeling (GO:0006338)
B-WICH complex [BFO:0000050 relation] BFO:0000050  nucleolus (GO:0005730)
B-WICH complex [RO:0002215 relation] RO:0002215  RNA polymerase I transcription regulatory region sequence-specific DNA binding (GO:0001163)
B-WICH complex [RO:0002215 relation] RO:0002215  rDNA binding (GO:0000182)
B-WICH complex [RO:0002216 relation] RO:0002216  positive regulation of transcription by RNA polymerase I (GO:0045943)
B-WICH complex [is_a relation] is_a  SWI/SNF superfamily-type complex (GO:0070603)
B-WICH complex [RO:0002215 relation] RO:0002215  rRNA binding (GO:0019843)

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None.