AmiGO 2: Term Details for "class I DNA-(apurinic or apyrimidinic site) endonuclease activity" (GO:0140078)

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Term Information

Accession: GO:0140078
Name: class I DNA-(apurinic or apyrimidinic site) endonuclease activity
Ontology: molecular_function
Synonyms: AP site-DNA 5'-phosphomonoester-lyase activity, DNA-(apurinic or apyrimidinic site) 5'-phosphomonoester-lyase activity, DNA-(apurinic or apyrimidinic site) lyase activity, class I DNA-(apurinic or apyrimidinic site) lyase activity, AP endonuclease class I activity
Alternate IDs: None
Definition: Catalysis of the cleavage of an AP site 3' of the baseless site by a beta-lyase mechanism, leaving an unsaturated aldehyde, termed a 3'-(4-hydroxy-5-phospho-2-pentenal) residue, and a 5'-phosphate. Source: PMID:1698278, RHEA:66592
Comment: Note that this term is does not have parentage in the 'nuclease activity' branch of the ontology because both GO and the Enzyme Commission define nuclease activity as a type of hydrolysis. Class II AP endonuclease is a nuclease, but not Class I, III and IV.
History: See term history for GO:0140078 at QuickGO
Chem. react.: has participant hydron; has participant 5'-end 2'-deoxyribonucleotide(2-) residue; has participant 3'-end deoxyribonucleotide 2,3-dehydro-2,3-deoxyribose phosphate(2-) residue; has participant deoxyribonucleotide-(2'-deoxyribose)-deoxyribonucleotide residue(3-)
Subset: None
Related: Link to all genes and gene products annotated to class I DNA-(apurinic or apyrimidinic site) endonuclease activity (excluding "regulates").; Link to all direct and indirect annotations to class I DNA-(apurinic or apyrimidinic site) endonuclease activity (excluding "regulates").; Link to all direct and indirect annotations download (limited to first 10,000) for class I DNA-(apurinic or apyrimidinic site) endonuclease activity (excluding "regulates").

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For more information, please see the ontology relation documentation.

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Additional internal viewing options

GO:0003824 catalytic activity
GO:0003674 molecular_function
GO:0140640 catalytic activity, acting on a nucleic acid
GO:0140097 catalytic activity, acting on DNA
GO:0016829 lyase activity
GO:0016835 carbon-oxygen lyase activity
GO:0003906 DNA-(apurinic or apyrimidinic site) endonuclease activity
GO:0140078 class I DNA-(apurinic or apyrimidinic site) endonuclease activity

Parents of class I DNA-(apurinic or apyrimidinic site) endonuclease activity (GO:0140078)

subject	relation	object
class I DNA-(apurinic or apyrimidinic site) endonuclease activity	RO:0000057	hydron (CHEBI:15378)
class I DNA-(apurinic or apyrimidinic site) endonuclease activity	is_a	carbon-oxygen lyase activity (GO:0016835)
class I DNA-(apurinic or apyrimidinic site) endonuclease activity	RO:0000057	5'-end 2'-deoxyribonucleotide(2-) residue (CHEBI:136412)
class I DNA-(apurinic or apyrimidinic site) endonuclease activity	RO:0000057	3'-end deoxyribonucleotide 2,3-dehydro-2,3-deoxyribose phosphate(2-) residue (CHEBI:157695)
class I DNA-(apurinic or apyrimidinic site) endonuclease activity	RO:0000057	deoxyribonucleotide-(2'-deoxyribose)-deoxyribonucleotide residue(3-) (CHEBI:167181)
class I DNA-(apurinic or apyrimidinic site) endonuclease activity	is_a	DNA-(apurinic or apyrimidinic site) endonuclease activity (GO:0003906)

This term has no children.

EC: 4.2.99.18
MetaCyc: 4.2.99.18-RXN
RHEA: 66592
Wikipedia: AP_endonuclease