AmiGO 2: Term Details for "flippase activity" (GO:0140327)

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Term Information

Accession: GO:0140327
Name: flippase activity
Ontology: molecular_function
Synonyms: flippase activity (exoplasmic to cytosolic leaftlet)
Alternate IDs: None
Definition: Catalysis of the movement of lipids from the exoplasmic to the cytosolic leaftlet of a membrane, using energy from the hydrolysis of ATP. Source: PMID:20043909, PMID:25284293, Wikipedia:Flippase
Comment: Nomenclature note. Flippases and floppases are ATP-dependent transbilayer lipid translocators. According to an extensively used, though not universal, nomenclature, they catalyze lipid transfer towards the inward monolayer (flippases) or towards the outward monolayer (floppases). Scramblases are ATP-independent, non-selective, inducing non-specific transbilayer movements across the membrane. The direction of the translocation should be taken into account for annotation (from the exoplasmic to the cytosolic leaftlet of a membrane).
History: See term history for GO:0140327 at QuickGO
Chem. react.: None
Subset: None
Related: Link to all genes and gene products annotated to flippase activity (excluding "regulates").; Link to all direct and indirect annotations to flippase activity (excluding "regulates").; Link to all direct and indirect annotations download (limited to first 10,000) for flippase activity (excluding "regulates").

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For more information, please see the ontology relation documentation.

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GO:0008150 biological_process
GO:0009987 cellular process
GO:0051179 localization
GO:0071840 cellular component organization or biogenesis
GO:0051234 establishment of localization
GO:0065007 biological regulation
GO:0016043 cellular component organization
GO:0033036 macromolecule localization
GO:0006810 transport
GO:0010876 lipid localization
GO:0061024 membrane organization
GO:0003674 molecular_function
GO:0071702 organic substance transport
GO:0065008 regulation of biological quality
GO:0006869 lipid transport
GO:0097035 regulation of membrane lipid distribution
GO:0005215 transporter activity
GO:0034204 lipid translocation
GO:0005319 lipid transporter activity
GO:0140657 ATP-dependent activity
GO:0140303 intramembrane lipid transporter activity
GO:0140326 ATPase-coupled intramembrane lipid transporter activity
GO:0140327 flippase activity
GO:0015247 aminophospholipid flippase activity
GO:0140333 glycerophospholipid flippase activity
GO:0140351 glycosylceramide flippase activity

Parents of flippase activity (GO:0140327)

subject	relation	object
flippase activity	is_a	ATPase-coupled intramembrane lipid transporter activity (GO:0140326)

Children of flippase activity (GO:0140327)

subject	relation	object
aminophospholipid flippase activity (GO:0015247)	is_a	flippase activity
glycosylceramide flippase activity (GO:0140351)	is_a	flippase activity
glycerophospholipid flippase activity (GO:0140333)	is_a	flippase activity

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