AmiGO 2: Term Details for "P-type transmembrane transporter activity" (GO:0140358)

Accession: GO:0140358
Name: P-type transmembrane transporter activity
Ontology: molecular_function
Synonyms: E1-E2 ATPase, P-type ATPase
Alternate IDs: None
Definition: Primary active transporter that auto-phosphorylates (hence P) at a key conserved aspartate residue, generating a conformational change that allows transport of the substrate. Hydrolysis of the phosphorylated Asp residue, catalyzed by the actuator (A) domain, results in another state with occluded substrates. Upon dissociation of Mg2+ and Pi, the enzyme reverts to the initial state, in which the counter-transported substrate is released into the cytosol. Source: PMID:18075584, PMID:25918123
Comment: None
History: See term history for GO:0140358 at QuickGO
Chem. react.: None
Subset: None
Related: Link to all genes and gene products annotated to P-type transmembrane transporter activity (excluding "regulates").; Link to all direct and indirect annotations to P-type transmembrane transporter activity (excluding "regulates").; Link to all direct and indirect annotations download (limited to first 10,000) for P-type transmembrane transporter activity (excluding "regulates").

Include "regulates"
For more information, please see the ontology relation documentation.

subject	relation	object
P-type transmembrane transporter activity	is_a	ATPase-coupled transmembrane transporter activity (GO:0042626)

subject	relation	object
P-type ion transporter activity (GO:0015662)	is_a	P-type transmembrane transporter activity