AmiGO 2: Term Details for "integrated stress response signaling" (GO:0140467)

Accession: GO:0140467
Name: integrated stress response signaling
Ontology: biological_process
Synonyms: ISR
Alternate IDs: None
Definition: The series of molecular signals generated in response to diverse stress stimuli required to restore cellular homeostasis. The core event in this pathway is the phosphorylation of eIF2 alpha by one of four members of the eIF2a kinase family (EIF2AK1/HRI, EIF2AK2/PKR, EIF2AK3/PERK and EIF2AK4/GCN2), which leads to a decrease in global protein synthesis and the induction of selected genes, including the transcription factor ATF4, that together promote cellular recovery. Source: PMID:27629041
Comment: None
History: See term history for GO:0140467 at QuickGO
Chem. react.: None
Subset: None
Related: Link to all genes and gene products annotated to integrated stress response signaling (excluding "regulates").; Link to all direct and indirect annotations to integrated stress response signaling (excluding "regulates").; Link to all direct and indirect annotations download (limited to first 10,000) for integrated stress response signaling (excluding "regulates").

Include "regulates"
For more information, please see the ontology relation documentation.

subject	relation	object
integrated stress response signaling	is_a	cellular response to stress (GO:0033554)
integrated stress response signaling	is_a	intracellular signaling cassette (GO:0141124)

subject	relation	object
GCN2-mediated signaling (GO:0140469)	is_a	integrated stress response signaling
HRI-mediated signaling (GO:0140468)	is_a	integrated stress response signaling
PERK-mediated unfolded protein response (GO:0036499)	is_a	integrated stress response signaling
PKR/eIFalpha signaling (GO:0039585)	is_a	integrated stress response signaling