AmiGO 2: Term Details for "nuclear receptor corepressor activity" (GO:0140536)

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Term Information

Accession: GO:0140536
Name: nuclear receptor corepressor activity
Ontology: molecular_function
Synonyms: nuclear corepressor activity
Alternate IDs: None
Definition: A transcription corepressor activity that represses or decreases the transcription of specific gene sets via binding to a DNA-bound nuclear receptor, either on its own or as part of a complex. Nuclear receptor corepressors often act by altering chromatin structure and modifications. For example, one class of transcription nuclear receptor corepressors modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. Source: PMID:7566126, PMID:7566114, PMID:9238851
Comment: For usage guidance, see comment in GO:0003712 ; transcription coregulator activity.
History: See term history for GO:0140536 at QuickGO
Chem. react.: None
Subset: None
Related: Link to all genes and gene products annotated to nuclear receptor corepressor activity (excluding "regulates").; Link to all direct and indirect annotations to nuclear receptor corepressor activity (excluding "regulates").; Link to all direct and indirect annotations download (limited to first 10,000) for nuclear receptor corepressor activity (excluding "regulates").

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For more information, please see the ontology relation documentation.

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GO:0008150 biological_process
GO:0065007 biological regulation
GO:0009987 cellular process
GO:0050789 regulation of biological process
GO:0009058 biosynthetic process
GO:0044237 cellular metabolic process
GO:0008152 metabolic process
GO:0048519 negative regulation of biological process
GO:0071704 organic substance metabolic process
GO:0044238 primary metabolic process
GO:0050794 regulation of cellular process
GO:0019222 regulation of metabolic process
GO:0044249 cellular biosynthetic process
GO:0043170 macromolecule metabolic process
GO:0048523 negative regulation of cellular process
GO:0009892 negative regulation of metabolic process
GO:0006139 nucleobase-containing compound metabolic process
GO:1901360 organic cyclic compound metabolic process
GO:1901576 organic substance biosynthetic process
GO:0009889 regulation of biosynthetic process
GO:0031323 regulation of cellular metabolic process
GO:0080090 regulation of primary metabolic process
GO:0009059 macromolecule biosynthetic process
GO:0009890 negative regulation of biosynthetic process
GO:0031324 negative regulation of cellular metabolic process
GO:0090304 nucleic acid metabolic process
GO:1901362 organic cyclic compound biosynthetic process
GO:0031326 regulation of cellular biosynthetic process
GO:0060255 regulation of macromolecule metabolic process
GO:0019219 regulation of nucleobase-containing compound metabolic process
GO:0016070 RNA metabolic process
GO:0010467 gene expression
GO:0003674 molecular_function
GO:0031327 negative regulation of cellular biosynthetic process
GO:0010605 negative regulation of macromolecule metabolic process
GO:0045934 negative regulation of nucleobase-containing compound metabolic process
GO:0141187 nucleic acid biosynthetic process
GO:0034654 nucleobase-containing compound biosynthetic process
GO:0010556 regulation of macromolecule biosynthetic process
GO:0051252 regulation of RNA metabolic process
GO:0032774 RNA biosynthetic process
GO:0006351 DNA-templated transcription
GO:0060090 molecular adaptor activity
GO:0010558 negative regulation of macromolecule biosynthetic process
GO:0051253 negative regulation of RNA metabolic process
GO:0010468 regulation of gene expression
GO:2001141 regulation of RNA biosynthetic process
GO:1902679 negative regulation of RNA biosynthetic process
GO:0030674 protein-macromolecule adaptor activity
GO:0006355 regulation of DNA-templated transcription
GO:0006366 transcription by RNA polymerase II
GO:0140110 transcription regulator activity
GO:0045892 negative regulation of DNA-templated transcription
GO:0006357 regulation of transcription by RNA polymerase II
GO:0003712 transcription coregulator activity
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0003714 transcription corepressor activity
GO:0140536 nuclear receptor corepressor activity

Parents of nuclear receptor corepressor activity (GO:0140536)

subject	relation	object
nuclear receptor corepressor activity	BFO:0000050	negative regulation of transcription by RNA polymerase II (GO:0000122)
nuclear receptor corepressor activity	is_a	transcription corepressor activity (GO:0003714)

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