AmiGO 2: Term Details for "ubiquitin-dependent protein catabolic process via the C-end degron rule pathway" (GO:0140627)

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Term Information

Accession: GO:0140627
Name: ubiquitin-dependent protein catabolic process via the C-end degron rule pathway
Ontology: biological_process
Synonyms: DesCEND
Alternate IDs: None
Definition: The chemical reactions and pathways resulting in the breakdown of a protein or peptide covalently tagged with ubiquitin, via the DesCEND (destruction via C-end degron) pathway. In the DesCEND pathway, C-terminal residues (C-end degrons) in substrates are recognized by Cul2-RING and Cul4-RING E3 ligases, whereupon the substrates are linked to ubiquitin and then delivered to the proteasome for degradation. C-end degrons can be present in full-length proteins, truncated proteins or proteolytically cleaved forms. Source: PMID:29775578, PMID:29779948
Comment: None
History: See term history for GO:0140627 at QuickGO
Chem. react.: None
Subset: None
Related: Link to all genes and gene products annotated to ubiquitin-dependent protein catabolic process via the C-end degron rule pathway (excluding "regulates").; Link to all direct and indirect annotations to ubiquitin-dependent protein catabolic process via the C-end degron rule pathway (excluding "regulates").; Link to all direct and indirect annotations download (limited to first 10,000) for ubiquitin-dependent protein catabolic process via the C-end degron rule pathway (excluding "regulates").

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GO:0008150 biological_process
GO:0008152 metabolic process
GO:0009056 catabolic process
GO:0071704 organic substance metabolic process
GO:0009057 macromolecule catabolic process
GO:0043170 macromolecule metabolic process
GO:1901575 organic substance catabolic process
GO:1901564 organonitrogen compound metabolic process
GO:0044238 primary metabolic process
GO:0019538 protein metabolic process
GO:0043632 modification-dependent macromolecule catabolic process
GO:1901565 organonitrogen compound catabolic process
GO:0030163 protein catabolic process
GO:0006508 proteolysis
GO:0051603 proteolysis involved in protein catabolic process
GO:0019941 modification-dependent protein catabolic process
GO:0010498 proteasomal protein catabolic process
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0140627 ubiquitin-dependent protein catabolic process via the C-end degron rule pathway

Parents of ubiquitin-dependent protein catabolic process via the C-end degron rule pathway (GO:0140627)

subject	relation	object
ubiquitin-dependent protein catabolic process via the C-end degron rule pathway	is_a	proteasome-mediated ubiquitin-dependent protein catabolic process (GO:0043161)

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