Term Information

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Accession
GO:0140999
Name
histone H3K4 trimethyltransferase activity
Ontology
molecular_function
Synonyms
histone H3K4 trimethylase activity, histone lysine N-trimethyltransferase activity (H3-K4 specific), histone H3-K4 trimethylation, histone H3K4 trimethylation
Alternate IDs
None
Definition
Catalysis of the reaction: L-lysyl4-[histone H3] + 3 S-adenosyl-L-methionine = 2 H+ + N6,N6-trimethyl-L-lysyl4-[histone H3] + 3 S-adenosyl-L-homocysteine. This reaction is the successive addition of three methyl groups to the unmethylated lysine residue at position 4 of histone H3, producing histone H3K4me3. Source: RHEA:60260, PMID:18375658
Comment
None
History
See term history for GO:0140999 at QuickGO
Chem. react.
has participant S-adenosyl-L-homocysteine zwitterion
has participant S-adenosyl-L-methionine zwitterion
has participant hydron
has participant N(6),N(6),N(6)-trimethyl-L-lysine residue
has participant L-lysinium residue
Subset
None
Include "regulates"
For more information, please see the ontology relation documentation.

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Graph of GO:0140999 from QuickGO

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Parents of histone H3K4 trimethyltransferase activity (GO:0140999)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
histone H3K4 trimethyltransferase activity [RO:0000057 relation] RO:0000057  S-adenosyl-L-homocysteine zwitterion (CHEBI:57856)
histone H3K4 trimethyltransferase activity [RO:0000057 relation] RO:0000057  S-adenosyl-L-methionine zwitterion (CHEBI:59789)
histone H3K4 trimethyltransferase activity [RO:0000057 relation] RO:0000057  hydron (CHEBI:15378)
histone H3K4 trimethyltransferase activity [is_a relation] is_a  histone H3K4 methyltransferase activity (GO:0042800)
histone H3K4 trimethyltransferase activity [RO:0000057 relation] RO:0000057  N(6),N(6),N(6)-trimethyl-L-lysine residue (CHEBI:61961)
histone H3K4 trimethyltransferase activity [RO:0000057 relation] RO:0000057  L-lysinium residue (CHEBI:29969)

This term has no children.

EC
2.1.1.354
RHEA
60260