AmiGO 2: Term Details for "macrolide transmembrane transporter complex" (GO:1990195)

Accession: GO:1990195
Name: macrolide transmembrane transporter complex
Ontology: cellular_component
Synonyms: macrolide transporter, AcrAB-TolC complex, MacAB-TolC complex, macrolide transporter complex
Alternate IDs: None
Definition: A bacterial transmembrane transporter complex that spans the entire cell membrane system and possesses ATP-dependent xenobiotic transport activity pumping drugs (typically antibiotics) and other toxins directly from the cytosol out of the bacterial cell. Typically, it is trimeric consisting of a inner membrane ATPase (IMP), a periplasmic membrane fusion protein (MFP) and an outer membrane factor (OMF). In E. coli, macrolide transporter complexes may consists of MacB (IMP), MacA (MFP) and TolC (OMF) or AcrB (IMP), AcrA (MFP) and TolC (OMF). Trimeric TolC is a common OMF found in many macrolide transporter complexes. Source: PMID:10879525, PMID:18955484, PMID:19254725, GOC:bhm
Comment: None
History: See term history for GO:1990195 at QuickGO
Chem. react.: None
Subset: None
Related: Link to all genes and gene products annotated to macrolide transmembrane transporter complex (excluding "regulates").; Link to all direct and indirect annotations to macrolide transmembrane transporter complex (excluding "regulates").; Link to all direct and indirect annotations download (limited to first 10,000) for macrolide transmembrane transporter complex (excluding "regulates").

Include "regulates"
For more information, please see the ontology relation documentation.

subject	relation	object
macrolide transmembrane transporter complex	RO:0002162	Bacteria (NCBITaxon:2)
macrolide transmembrane transporter complex	is_a	transmembrane transporter complex (GO:1902495)

subject	relation	object
MacAB-TolC complex (GO:1990196)	is_a	macrolide transmembrane transporter complex

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