AmiGO 2: Term Details for "platelet-derived growth factor complex" (GO:1990265)

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Term Information

Accession: GO:1990265
Name: platelet-derived growth factor complex
Ontology: cellular_component
Synonyms: PDGF complex, PDGF-AA dimer, PDGF-AB dimer, PDGF-BB dimer, PDGF-CC dimer, PDGF-DD dimer
Alternate IDs: None
Definition: A protein complex consisting of two chains of platelet-derived growth factor (PDGF) subunits. PDGF dimers bind to PDGF receptors in the plasma membrane and induce receptor dimerization and activation. PDGFs are involved in a wide variety of signaling processes. PDGFs are found in all vertebrates where at least 2 different chains (A and B) exist. In human (and other mammals), four types of PDGF chains (A, B, C, and D) are known which form five different dimers (AA, AB, BB, CC and DD). Source: PMID:11331882, GOC:bhm
Comment: An example of this is PDGFA in human (P04085) in PMID:20534510 (inferred from direct assay).
History: See term history for GO:1990265 at QuickGO
Chem. react.: None
Subset: None
Related: Link to all genes and gene products annotated to platelet-derived growth factor complex (excluding "regulates").; Link to all direct and indirect annotations to platelet-derived growth factor complex (excluding "regulates").; Link to all direct and indirect annotations download (limited to first 10,000) for platelet-derived growth factor complex (excluding "regulates").

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GO:0008150 biological_process
GO:0065007 biological regulation
GO:0003674 molecular_function
GO:0005488 binding
GO:0009987 cellular process
GO:0098772 molecular function regulator activity
GO:0050789 regulation of biological process
GO:0050896 response to stimulus
GO:0007154 cell communication
GO:0051716 cellular response to stimulus
GO:0140677 molecular function activator activity
GO:0060089 molecular transducer activity
GO:0005515 protein binding
GO:0050794 regulation of cellular process
GO:0023052 signaling
GO:0030545 signaling receptor regulator activity
GO:0007165 signal transduction
GO:0030546 signaling receptor activator activity
GO:0038023 signaling receptor activity
GO:0005102 signaling receptor binding
GO:0005575 cellular_component
PR:000050567 protein-containing material entity
GO:0048018 receptor ligand activity
GO:0008083 growth factor activity
GO:0032991 protein-containing complex
GO:0036454 growth factor complex
GO:1990265 platelet-derived growth factor complex

Parents of platelet-derived growth factor complex (GO:1990265)

subject	relation	object
platelet-derived growth factor complex	is_a	growth factor complex (GO:0036454)

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