AmiGO 2: Term Details for "CLOCK-BMAL transcription complex" (GO:1990513)

Term Information

Accession: GO:1990513
Name: CLOCK-BMAL transcription complex
Ontology: cellular_component
Synonyms: CLOCK/BMAL complex
Alternate IDs: None
Definition: Transcription factor complex which interacts with E-box regulatory elements in target genes, including Period (Per1, Per2, Per3) and Cryptochrome (Cry1, Cry2), to activate their transcription during the daytime. The CRY-PER complexes inhibit CLOCK-BMAL1-driven transcription in a negative feedback loop to generate circadian rhythms. Source: PMID:23229515, GOC:bhm
Comment: An example of this is CLOCK in human (O15516) in PMID:23229515 (inferred from physical interaction).
History: See term history for GO:1990513 at QuickGO
Chem. react.: None
Subset: None
Related: Link to all genes and gene products annotated to CLOCK-BMAL transcription complex (excluding "regulates").; Link to all direct and indirect annotations to CLOCK-BMAL transcription complex (excluding "regulates").; Link to all direct and indirect annotations download (limited to first 10,000) for CLOCK-BMAL transcription complex (excluding "regulates").

Include "regulates"
For more information, please see the ontology relation documentation.

Filter results

View this term in QuickGO.

Additional external viewing options

OLSVis (interactive)

Additional internal viewing options

CARO:0030000 biological entity
CARO:0000000 anatomical entity
UBERON:0001062 anatomical entity
CARO:0000006 material anatomical entity
CARO:0000003 connected anatomical structure
UBERON:0000465 material anatomical entity
GO:0003674 molecular_function
UBERON:0000061 anatomical structure
GO:0005488 binding
GO:0008150 biological_process
GO:0005575 cellular_component
GO:0003676 nucleic acid binding
CL:0000000 cell
GO:0110165 cellular anatomical entity
GO:0009987 cellular process
GO:0003677 DNA binding
GO:0008152 metabolic process
GO:0043226 organelle
GO:0097159 organic cyclic compound binding
GO:0071704 organic substance metabolic process
GO:0048518 positive regulation of biological process
GO:0044238 primary metabolic process
GO:0050789 regulation of biological process
GO:0050794 regulation of cellular process
GO:0019222 regulation of metabolic process
GO:0009058 biosynthetic process
GO:0044237 cellular metabolic process
GO:0003690 double-stranded DNA binding
GO:0005622 intracellular anatomical structure
GO:0043229 intracellular organelle
GO:0043170 macromolecule metabolic process
GO:0043228 non-membrane-bounded organelle
GO:0006139 nucleobase-containing compound metabolic process
GO:1901360 organic cyclic compound metabolic process
GO:1901576 organic substance biosynthetic process
GO:0048522 positive regulation of cellular process
GO:0009893 positive regulation of metabolic process
GO:0009889 regulation of biosynthetic process
GO:0031323 regulation of cellular metabolic process
GO:0080090 regulation of primary metabolic process
GO:0043565 sequence-specific DNA binding
GO:0044249 cellular biosynthetic process
GO:0006351 DNA-templated transcription
GO:0043232 intracellular non-membrane-bounded organelle
GO:0043227 membrane-bounded organelle
GO:0090304 nucleic acid metabolic process
GO:1901362 organic cyclic compound biosynthetic process
GO:0009891 positive regulation of biosynthetic process
GO:0031325 positive regulation of cellular metabolic process
GO:0032991 protein-containing complex
GO:0031326 regulation of cellular biosynthetic process
GO:0060255 regulation of macromolecule metabolic process
GO:0019219 regulation of nucleobase-containing compound metabolic process
GO:0016070 RNA metabolic process
GO:1990837 sequence-specific double-stranded DNA binding
GO:0001067 transcription regulatory region nucleic acid binding
GO:0065007 biological regulation
GO:0005694 chromosome
GO:0043231 intracellular membrane-bounded organelle
GO:0009059 macromolecule biosynthetic process
GO:0141187 nucleic acid biosynthetic process
GO:0034654 nucleobase-containing compound biosynthetic process
GO:0031328 positive regulation of cellular biosynthetic process
GO:0010604 positive regulation of macromolecule metabolic process
GO:0045935 positive regulation of nucleobase-containing compound metabolic process
PR:000050567 protein-containing material entity
GO:0032993 protein-DNA complex
GO:0006355 regulation of DNA-templated transcription
GO:0010556 regulation of macromolecule biosynthetic process
GO:0051252 regulation of RNA metabolic process
GO:0032774 RNA biosynthetic process
GO:0006366 transcription by RNA polymerase II
GO:0000976 transcription cis-regulatory region binding
GO:0140110 transcription regulator activity
GO:0000785 chromatin
GO:0007623 circadian rhythm
GO:0000987 cis-regulatory region sequence-specific DNA binding
GO:0003700 DNA-binding transcription factor activity
GO:0010467 gene expression
GO:0005634 nucleus
GO:0010557 positive regulation of macromolecule biosynthetic process
GO:0051254 positive regulation of RNA metabolic process
GO:0010468 regulation of gene expression
GO:2001141 regulation of RNA biosynthetic process
GO:0006357 regulation of transcription by RNA polymerase II
GO:0048511 rhythmic process
GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0140513 nuclear protein-containing complex
GO:1902680 positive regulation of RNA biosynthetic process
GO:0042752 regulation of circadian rhythm
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0005667 transcription regulator complex
GO:0032922 circadian regulation of gene expression
GO:0070888 E-box binding
GO:0042753 positive regulation of circadian rhythm
GO:0045893 positive regulation of DNA-templated transcription
GO:0090575 RNA polymerase II transcription regulator complex
GO:1990513 CLOCK-BMAL transcription complex

Parents of CLOCK-BMAL transcription complex (GO:1990513)

subject	relation	object
CLOCK-BMAL transcription complex	RO:0002216	circadian regulation of gene expression (GO:0032922)
CLOCK-BMAL transcription complex	is_a	RNA polymerase II transcription regulator complex (GO:0090575)
CLOCK-BMAL transcription complex	RO:0002215	E-box binding (GO:0070888)
CLOCK-BMAL transcription complex	RO:0002216	positive regulation of circadian rhythm (GO:0042753)
CLOCK-BMAL transcription complex	RO:0002216	positive regulation of DNA-templated transcription (GO:0045893)

This term has no children.

GONUTS Add usage comments for this term on the GONUTS wiki.