AmiGO 2: Term Details for "calprotectin complex" (GO:1990660)

Term Information

Accession: GO:1990660
Name: calprotectin complex
Ontology: cellular_component
Synonyms: calprotectin heterodimer
Alternate IDs: None
Definition: A protein complex composed of S100A8 and S100A9 and capable of limiting Mn(2+) and Zn(2+) availability at sites of infection. Also binds Ca(2+). Expressed and released by neutrophils and epithelial cells, it exhibits broad-spectrum antimicrobial activity attributed to its metal-binding properties. Endogenous ligand of toll-like receptor 4 (TLR4) and of the receptor for advanced glycation end products (RAGE) initiating signal transduction through NF-kappa-B pathways. Source: PMID:25417112, GOC:bhm
Comment: An example of this is S100A9 in human (UniProt symbol P06702) in PMID:25417112 (inferred from direct assay).
History: See term history for GO:1990660 at QuickGO
Chem. react.: None
Subset: None
Related: Link to all genes and gene products annotated to calprotectin complex (excluding "regulates").; Link to all direct and indirect annotations to calprotectin complex (excluding "regulates").; Link to all direct and indirect annotations download (limited to first 10,000) for calprotectin complex (excluding "regulates").

Include "regulates"
For more information, please see the ontology relation documentation.

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GO:0008150 biological_process
GO:0050789 regulation of biological process
GO:0002376 immune system process
GO:0048518 positive regulation of biological process
GO:0002682 regulation of immune system process
GO:0048583 regulation of response to stimulus
GO:0050896 response to stimulus
CARO:0030000 biological entity
GO:0006952 defense response
GO:0006955 immune response
GO:0002684 positive regulation of immune system process
GO:0048584 positive regulation of response to stimulus
GO:0031347 regulation of defense response
GO:0050776 regulation of immune response
GO:0002831 regulation of response to biotic stimulus
GO:0032101 regulation of response to external stimulus
GO:0009607 response to biotic stimulus
GO:0009605 response to external stimulus
CARO:0000000 anatomical entity
CL:0000000 cell
GO:0042592 homeostatic process
GO:0045087 innate immune response
GO:0031349 positive regulation of defense response
GO:0050778 positive regulation of immune response
GO:0002833 positive regulation of response to biotic stimulus
GO:0032103 positive regulation of response to external stimulus
GO:0045088 regulation of innate immune response
GO:0007165 signal transduction
GO:0002253 activation of immune response
UBERON:0001062 anatomical entity
GO:0005488 binding
GO:0065007 biological regulation
GO:0019725 cellular homeostasis
GO:0009987 cellular process
GO:0048878 chemical homeostasis
GO:0002764 immune response-regulating signaling pathway
CARO:0000006 material anatomical entity
GO:0045089 positive regulation of innate immune response
GO:0006950 response to stress
GO:0002218 activation of innate immune response
GO:0007154 cell communication
GO:0051716 cellular response to stimulus
CARO:0000003 connected anatomical structure
GO:0002757 immune response-activating signaling pathway
GO:0055082 intracellular chemical homeostasis
UBERON:0000465 material anatomical entity
GO:0003674 molecular_function
GO:0050801 monoatomic ion homeostasis
GO:0050794 regulation of cellular process
GO:0080134 regulation of response to stress
GO:0023052 signaling
GO:0036094 small molecule binding
UBERON:0000061 anatomical structure
GO:0044419 biological process involved in interspecies interaction between organisms
GO:0002758 innate immune response-activating signaling pathway
GO:0098771 inorganic ion homeostasis
GO:0006873 intracellular monoatomic ion homeostasis
GO:0043167 ion binding
GO:0051179 localization
GO:0055080 monoatomic cation homeostasis
GO:0010646 regulation of cell communication
GO:0023051 regulation of signaling
GO:0043207 response to external biotic stimulus
GO:0043169 cation binding
GO:0051641 cellular localization
GO:0098542 defense response to other organism
GO:0030003 intracellular monoatomic cation homeostasis
GO:0051235 maintenance of location
GO:0055071 manganese ion homeostasis
GO:0046872 metal ion binding
GO:0002221 pattern recognition receptor signaling pathway
GO:0005515 protein binding
GO:0009966 regulation of signal transduction
GO:0051707 response to other organism
GO:0005102 signaling receptor binding
GO:0005575 cellular_component
GO:0140546 defense response to symbiont
GO:0030026 intracellular manganese ion homeostasis
GO:0006882 intracellular zinc ion homeostasis
GO:0051651 maintenance of location in cell
PR:000050567 protein-containing material entity
GO:0062207 regulation of pattern recognition receptor signaling pathway
GO:0009617 response to bacterium
GO:0051238 sequestering of metal ion
GO:0035325 Toll-like receptor binding
GO:0002224 toll-like receptor signaling pathway
GO:0046914 transition metal ion binding
GO:0005509 calcium ion binding
GO:0042742 defense response to bacterium
GO:0030145 manganese ion binding
GO:0032991 protein-containing complex
GO:0050786 RAGE receptor binding
GO:0034121 regulation of toll-like receptor signaling pathway
GO:0009611 response to wounding
GO:1990659 sequestering of manganese ion
GO:0032119 sequestering of zinc ion
GO:0035662 Toll-like receptor 4 binding
GO:1990660 calprotectin complex

Parents of calprotectin complex (GO:1990660)

subject	relation	object
calprotectin complex	RO:0002216	sequestering of zinc ion (GO:0032119)
calprotectin complex	RO:0002216	innate immune response (GO:0045087)
calprotectin complex	RO:0002215	Toll-like receptor 4 binding (GO:0035662)
calprotectin complex	RO:0002216	regulation of toll-like receptor signaling pathway (GO:0034121)
calprotectin complex	RO:0002215	calcium ion binding (GO:0005509)
calprotectin complex	RO:0002216	sequestering of manganese ion (GO:1990659)
calprotectin complex	RO:0002215	RAGE receptor binding (GO:0050786)
calprotectin complex	RO:0002216	response to wounding (GO:0009611)
calprotectin complex	RO:0002215	manganese ion binding (GO:0030145)
calprotectin complex	RO:0002216	defense response to bacterium (GO:0042742)
calprotectin complex	is_a	protein-containing complex (GO:0032991)

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