surpassing genetic interaction
mutual genetic over-suppression
MI:1287
2013-06-05T21:06:09Z
PSI-MI
orchard
An effect in which individual perturbations of different genes result in the same mutant phenotype (but, perhaps, to varying degrees of severity/penetrance) and the resulting phenotype of their combination is opposite (relative to wild type) to that expected from the original phenotypes. With respect to any single quantifiable phenotype, this may be expressed as an inequality as:
a* <= b < wt < ab [E = a*]
OR
ab < wt < b <= a* [E = a*]
where 'a' and 'b' are the observed phenotype values of the individual perturbations ('a*' being the most severe of the two), 'ab' is the observed phenotype value of the double perturbation, 'E' is the expected phenotype value of the double perturbation, and 'wt' is the wild type phenotype value.
cisphenotypic super-suppressing genetic interaction
cisphenotypic phenotype result
genetic over-suppression