2-pyrrolidone-5-carboxylic acid (Glu)
(2S)-5-oxo-2-pyrrolidinecarboxylic acid
-18.0106
-18.02
112.04
112.11
2-oxopyrrolidine-5-carboxylic acid
2-pyrrolidone-5-carboxylic acid
5-oxoproline
5-oxopyrrolidine-2-carboxylic acid
5-pyrrolidone-2-carboxylic acid
A protein modification that effectively converts an L-glutamic acid residue to 2-pyrrolidone-5-carboxylic acid.
C 0 H -2 N 0 O -1
C 5 H 6 N 1 O 2
E
From DeltaMass: References: The conversion of glutamic acid to pyroglutamic was reported for the beta-amyloid protein. Miller et al. Arch. Biochem. Biophy. (1993) 301, 41-52 [DeltaMass]. The modification in amyloid protein is probably an artifact of treatment with strong acid under anhydrous conditions. Peptides with N-terminal glutamic acid isolated from single cells of Aplysia neurons show partial conversion to pyroglutamic acid, possibly dependent on a temperature sensitive factor [JSG].
Glu->pyro-Glu
MOD:00420
MOD_RES Pyrrolidone carboxylic acid (Glu)
N-term
PCA
PSI-MOD
PyrGlu(Glu)
Pyro-glu from E
Pyroglutamic Acid formed from Glutamic Acid
Unimod:27
artifact
ntermpeppyroe
pyroglutamic acid
uniprot.ptm:PTM-0262
modified L-glutamic acid residue
2-pyrrolidone-5-carboxylic acid