has part
has part
has_part
occurs in
occurs in
characteristic of part of
has modifier
migratory cranial neural crest cell
cell migration
abnormal neural crest cell migration
abnormal cranial neural crest cell migration
abnormal cephalic NCC migration
MPheno.ontology
abnormal head neural crest cell migration
abnormal head NCC migration
abnormal cephalic neural crest cell migration
any anomaly in the migratory path of the cranial neural crest cells (NCCs), which originate in the anterior part of the developing embryo and reside between the mid-diencephalon and the forming hindbrain; cranial NCCs migrate dorsolaterally to form the craniofacial mesenchyme that differentiates into various craniofacial cartilages and bones, cranial neurons, glia, and connective tissues of the face; these cells enter the pharyngeal pouches and arches where they give rise to thymic cells, bones of the middle ear and jaw (mandible), and the odontoblasts of the tooth primordial; like their counterparts in the trunk, cranial NCCs contribute to the developing peripheral nervous system, along with the pigmented cell (i.e. melanocyte) lineage
2014-04-09T16:15:56Z
MP:0012757
csmith
abnormal cranial NCC migration
quality
abnormal