Gene_Product_Is_Physical_Part_Of
CTRP Terminology
CTRP Biomarker Terminology
CTRP Molecular Genetic Biomarker Terminology
GDC Terminology
T-Cell Receptor
GDC Value Terminology
Protein or Riboprotein Complex
Antigen
CD3 Complex
Amino Acid, Peptide, or Protein
C0108779
C38897
CD3
CD3
CD3 Complex
CD3 Complex
CD3 Complex
CD3_Complex
CTRP
Consisting of cell surface type I membrane Delta, Epsilon, Gamma, Zeta, and Eta protein subunits with ITAM domains and noncovalently associated with the disulfide bound heterodimeric alpha/beta and gamma/delta TCR, the CD3 complex couples receptor antigen recognition to signal transduction pathways during T-cell activation. During TCR engagement with MHC-associated antigen on host cell surfaces and synapse formation, CD3 activity leads to Tyr-phosphorylated CD3 subunits, Tyr phosphorylation of LAT colocalized in lipid rafts, and MAPK activation. CD3 signal transduction appears to involve LCK, ZAP70, Nck, SLA, SLA2, and DOCK2. CD3 subunits may also associate with the cytoskeleton. CD3 also mediates TCR signal transduction during the developmental transition through positive selection of immature thymocytes to mature CD4+ or CD8+ T cells. (NCI)
GDC
T-Cell Surface Glycoprotein CD3
T3 Complex