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Protein Ontology report - cation channel sperm-associated protein 1
PR:000000669 - http://purl.obolibrary.org/obo/PR_000000669
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000000669   
  PRO namecation channel sperm-associated protein 1 
  Synonyms
PRO-Short-label: EXACT:CATSPER1
Other: EXACT:CatSper1
  Definition"A CatSper channel protein that is a translation product of the human CATSPER1 gene or a 1:1 ortholog thereof. In mammals, four CatSper ion channel subunit genes (CatSpers 1-4) are required for sperm cell hyperactivation and male fertility. The four proteins assemble (presumably as a tetramer) to form a sperm-specific, alkalinization-activated Ca(2+)-selective channel. CatSper channels seem to require auxiliary subunits, such as CatSperB (PR:000000672). In common with other channels, CatSper1 proteins have an architecture consisting of six transmembrane domains (S1-S6), arranged in a voltage sensor (S1-S4) and pore modules (S5-P-S6), and with both N and C termini on the intracellular side of the membrane. Unique to this class is the His-rich N terminus that seems to be involved the pH sensitivity of the channel calcium currents." [PRO:CNA] 
  PRO Categorygene 
  ParentPR:000044645
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 2                                        
         Sequence1                                                  Organism-Sequence 2                                        
         Modification1                                                  Organism-Modification 0                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
IUPHARobj:388
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Ann. Has Annotation?

Comp. In Complex?
gene


PR:000000669 cation channel sperm-associated protein 1, CATSPER1

organism-gene


PR:Q8NEC5 cation channel sperm-associated protein 1 (human), hCATSPER1

organism-sequence


PR:Q8NEC5-1 cation channel sperm-associated protein 1 isoform 1 (human), hCATSPER1/iso:1
Yes
organism-gene


PR:Q91ZR5 cation channel sperm-associated protein 1 (mouse), mCATSPER1
Yes
organism-sequence


PR:Q91ZR5-1 cation channel sperm-associated protein 1 isoform 1 (mouse), mCATSPER1/iso:1
Yes
sequence


PR:000000688 cation channel sperm-associated protein 1 isoform 1, CATSPER1/iso:1

organism-sequence


PR:Q91ZR5-1 cation channel sperm-associated protein 1 isoform 1 (mouse), mCATSPER1/iso:1
Yes
modification


PR:000002581 cation channel sperm-associated protein 1 isoform 1 unmodified form, CATSPER1/iso:1/UnMod

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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:Q8NEC5-1
hCATSPER1/iso:1
 enablesGO:0005515 protein binding with PR:Q9P0X4 Ca(v)3.3 (human) PMID:16740636
PR:Q91ZR5
mCATSPER1
Catsper1 | CatSper1 (mouse)		 acts_upstream_of_or_withinGO:0006816 calcium ion transport PMID:11595941
GO:0007342 fusion of sperm to egg plasma membrane involved in single fertilization PMID:11595941
GO:0030317 flagellated sperm motility PMID:11595941
PR:Q91ZR5-1
mCATSPER1/iso:1
 enablesGO:0005515 protein binding with PR:Q80W99-1 PMID:17227845
located_inGO:0005886 plasma membrane PMID:11595941
GO:0032991 protein-containing complex PMID:17478420