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Protein Ontology report - cation channel sperm-associated protein 1
PR:000000669 -
http://purl.obolibrary.org/obo/PR_000000669
Protein Forms
Annotations
Ontology Information
Show OBO stanza
PRO ID
PR:000000669
PRO name
cation channel sperm-associated protein 1
Synonyms
PRO-Short-label
:
EXACT:
CATSPER1
Other
:
EXACT:
CatSper1
Definition
"A CatSper channel protein that is a translation product of the human CATSPER1 gene or a 1:1 ortholog thereof. In mammals, four CatSper ion channel subunit genes (CatSpers 1-4) are required for sperm cell hyperactivation and male fertility. The four proteins assemble (presumably as a tetramer) to form a sperm-specific, alkalinization-activated Ca(2+)-selective channel. CatSper channels seem to require auxiliary subunits, such as CatSperB (
PR:000000672
). In common with other channels, CatSper1 proteins have an architecture consisting of six transmembrane domains (S1-S6), arranged in a voltage sensor (S1-S4) and pore modules (S5-P-S6), and with both N and C termini on the intracellular side of the membrane. Unique to this class is the His-rich N terminus that seems to be involved the pH sensitivity of the channel calcium currents." [PRO:CNA]
PRO Category
gene
Parent
PR:000044645
Terms by PRO Category
Organism-Independent
Organism-Specific
Category
Number of Terms
Category
Number of Terms
Gene
1
Organism-Gene
2
Sequence
1
Organism-Sequence
2
Modification
1
Organism-Modification
0
Term Hierarchy
Visualization
DAG:
OLS:
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Related Cross References
Db identifiers
IUPHARobj:388
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Protein Forms
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Extended View
Category
PRO Form Name
Ann.
Has Annotation?
Comp.
In Complex?
gene
PR:000000669
cation channel sperm-associated protein 1, CATSPER1
organism-gene
PR:Q8NEC5
cation channel sperm-associated protein 1 (human), hCATSPER1
organism-sequence
PR:Q8NEC5-1
cation channel sperm-associated protein 1 isoform 1 (human), hCATSPER1/iso:1
Yes
organism-gene
PR:Q91ZR5
cation channel sperm-associated protein 1 (mouse), mCATSPER1
Yes
organism-sequence
PR:Q91ZR5-1
cation channel sperm-associated protein 1 isoform 1 (mouse), mCATSPER1/iso:1
Yes
sequence
PR:000000688
cation channel sperm-associated protein 1 isoform 1, CATSPER1/iso:1
organism-sequence
PR:Q91ZR5-1
cation channel sperm-associated protein 1 isoform 1 (mouse), mCATSPER1/iso:1
Yes
modification
PR:000002581
cation channel sperm-associated protein 1 isoform 1 unmodified form, CATSPER1/iso:1/UnMod
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Functional Annotation (PRO-centric view)
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GO Centric View
PRO Term
GO Annotation
Evidence
PR:Q8NEC5-1
hCATSPER1/iso:1
enables
GO:0005515
protein binding
with
PR:Q9P0X4
Ca(v)3.3 (human)
PMID:16740636
PR:Q91ZR5
mCATSPER1
Catsper1 | CatSper1 (mouse)
acts_upstream_of_or_within
GO:0006816
calcium ion transport
PMID:11595941
GO:0007342
fusion of sperm to egg plasma membrane involved in single fertilization
PMID:11595941
GO:0030317
flagellated sperm motility
PMID:11595941
PR:Q91ZR5-1
mCATSPER1/iso:1
enables
GO:0005515
protein binding
with
PR:Q80W99-1
PMID:17227845
located_in
GO:0005886
plasma membrane
PMID:11595941
GO:0032991
protein-containing complex
PMID:17478420