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Protein Ontology report - cation channel sperm-associated protein 3
PR:000000671 - http://purl.obolibrary.org/obo/PR_000000671
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000000671   
  PRO namecation channel sperm-associated protein 3 
  Synonyms
PRO-Short-label: EXACT:CATSPER3
Other: EXACT:Ca(v)-like protein | CatSper3 | one-repeat calcium channel-like protein
  Definition"A CatSper channel protein that is a translation product of the human CATSPER3 gene or a 1:1 ortholog thereof. In mammals, four CatSper ion channel subunit genes (CatSpers 1-4) are required for sperm cell hyperactivation and male fertility. The four proteins assemble (presumably as a tetramer) to form a sperm-specific, alkalinization-activated Ca(2+)-selective channel. CatSper channels seem to require auxiliary subunits, such as CatSperB (PR:000000672). In common with other channels, CatSper3 proteins have an architecture consisting of six transmembrane domains (S1-S6), arranged in a voltage sensor (S1-S4) and pore modules (S5-P-S6), and with both N and C termini on the intracellular side of the membrane." [PRO:CNA] 
  PRO Categorygene 
  ParentPR:000044645
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 2                                        
         Sequence2                                                  Organism-Sequence 3                                        
         Modification0                                                  Organism-Modification 0                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
IUPHARobj:390
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Ann. Has Annotation?

Comp. In Complex?
gene


PR:000000671 cation channel sperm-associated protein 3, CATSPER3

organism-gene


PR:Q80W99 cation channel sperm-associated protein 3 (mouse), mCATSPER3
Yes
organism-sequence


PR:Q80W99-1 cation channel sperm-associated protein 3 isoform 1 (mouse), mCATSPER3/iso:1
Yes
organism-sequence


PR:Q80W99-2 cation channel sperm-associated protein 3 isoform 2 (mouse), mCATSPER3/iso:2

organism-gene


PR:Q86XQ3 cation channel sperm-associated protein 3 (human), hCATSPER3

organism-sequence


PR:Q86XQ3-1 cation channel sperm-associated protein 3 isoform 1 (human), hCATSPER3/iso:1

sequence


PR:000000693 cation channel sperm-associated protein 3 isoform 1, CATSPER3/iso:1

organism-sequence


PR:Q80W99-1 cation channel sperm-associated protein 3 isoform 1 (mouse), mCATSPER3/iso:1
Yes
organism-sequence


PR:Q86XQ3-1 cation channel sperm-associated protein 3 isoform 1 (human), hCATSPER3/iso:1

sequence


PR:000000694 cation channel sperm-associated protein 3 isoform 2, CATSPER3/iso:2

organism-sequence


PR:Q80W99-2 cation channel sperm-associated protein 3 isoform 2 (mouse), mCATSPER3/iso:2

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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:Q80W99
mCATSPER3
Catsper3 | CatSper3 (mouse)		 acts_upstream_of_or_withinGO:0001539 cilium or flagellum-dependent cell motility PMID:17227845
GO:0030317 flagellated sperm motility PMID:17227845
located_inGO:0001669 acrosomal vesicle PMID:16107607
PR:Q80W99-1
mCATSPER3/iso:1
 enablesGO:0005515 protein binding with PR:Q91ZR5-1 PMID:17227845