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Protein Ontology report - cGMP-gated cation channel alpha-1
PR:000000686 - http://purl.obolibrary.org/obo/PR_000000686
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000000686   
  PRO namecGMP-gated cation channel alpha-1 
  Synonyms
PRO-Short-label: EXACT:CNGA1
Gene-based: RELATED:CNCG | CNCG1
Other: EXACT:CNG channel alpha-1 | CNG-1 | CNG1 | cyclic nucleotide-gated cation channel 1 | cyclic nucleotide-gated channel alpha-1 | cyclic nucleotide-gated channel, photoreceptor | rod photoreceptor cGMP-gated channel subunit alpha
  Definition"A cyclic nucleotide-gated channel alpha subunit that is a translation product of the human CNGA1 gene or a 1:1 ortholog thereof. In the retina, these proteins can be activated by cyclic GMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors." [PRO:CNA] 
  PRO Categorygene 
  ParentPR:000000673 cyclic nucleotide-gated channel alpha subunit
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 5                                        
         Sequence1                                                  Organism-Sequence 4                                        
         Modification3                                                  Organism-Modification 4                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
IUPHARobj:394
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Ann. Has Annotation?

Comp. In Complex?
gene


PR:000000686 cGMP-gated cation channel alpha-1, CNGA1

organism-gene


PR:P29973 cGMP-gated cation channel alpha-1 (human), hCNGA1

organism-sequence


PR:000000738 cGMP-gated cation channel alpha-1 sequence variant S320F (human), hCNGA1/var:S320F
Yes
organism-sequence


PR:P29973-1 cGMP-gated cation channel alpha-1 isoform 1 (human), hCNGA1/iso:1
Yes
organism-modification


PR:000078527 cGMP-gated cation channel alpha-1 deaminated 1 (human), hCNGA1/Deam:1

organism-gene


PR:P29974 cGMP-gated cation channel alpha-1 (mouse), mCNGA1
Yes
organism-sequence


PR:P29974-1 cGMP-gated cation channel alpha-1 isoform 1 (mouse), mCNGA1/iso:1

organism-gene


PR:Q00194 cGMP-gated cation channel alpha-1 (cow), cow-CNGA1

organism-sequence


PR:Q00194-1 cGMP-gated cation channel alpha-1 isoform 1 (cow), cow-CNGA1/iso:1
Yes
organism-modification


PR:000036569 cGMP-gated cation channel alpha-1 isoform 1 phosphorylated 1 (cow), cow-CNGA1/iso:1/Phos:1
Yes
organism-modification


PR:000045379 cGMP-gated cation channel alpha-1 isoform 1 phosphorylated 2 (cow), cow-CNGA1/iso:1/Phos:2

organism-modification


PR:000045381 cGMP-gated cation channel alpha-1 isoform 1 unphosphorylated 1 (cow), cow-CNGA1/iso:1/UnPhos:1
Yes
organism-gene


PR:Q62927 cGMP-gated cation channel alpha-1 (rat), rCNGA1

organism-gene


PR:Q90980 cyclic nucleotide-gated channel rod photoreceptor subunit alpha (chicken), chick-CNGA1

sequence


PR:000000737 cGMP-gated cation channel alpha-1 isoform 1, CNGA1/iso:1

organism-sequence


PR:P29973-1 cGMP-gated cation channel alpha-1 isoform 1 (human), hCNGA1/iso:1
Yes
organism-sequence


PR:P29974-1 cGMP-gated cation channel alpha-1 isoform 1 (mouse), mCNGA1/iso:1

organism-sequence


PR:Q00194-1 cGMP-gated cation channel alpha-1 isoform 1 (cow), cow-CNGA1/iso:1
Yes
organism-modification


PR:000036569 cGMP-gated cation channel alpha-1 isoform 1 phosphorylated 1 (cow), cow-CNGA1/iso:1/Phos:1
Yes
organism-modification


PR:000045379 cGMP-gated cation channel alpha-1 isoform 1 phosphorylated 2 (cow), cow-CNGA1/iso:1/Phos:2

organism-modification


PR:000045381 cGMP-gated cation channel alpha-1 isoform 1 unphosphorylated 1 (cow), cow-CNGA1/iso:1/UnPhos:1
Yes
modification


PR:000000932 cGMP-gated cation channel alpha-1 isoform 1 phosphorylated form, CNGA1/iso:1/PhosRes+

modification


PR:000000981 cGMP-gated cation channel alpha-1 isoform 1 phosphorylated 1, CNGA1/iso:1/Phos:1

organism-modification


PR:000036569 cGMP-gated cation channel alpha-1 isoform 1 phosphorylated 1 (cow), cow-CNGA1/iso:1/Phos:1
Yes
modification


PR:000045378 cGMP-gated cation channel alpha-1 isoform 1 phosphorylated 2, CNGA1/iso:1/Phos:2

organism-modification


PR:000045379 cGMP-gated cation channel alpha-1 isoform 1 phosphorylated 2 (cow), cow-CNGA1/iso:1/Phos:2

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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000000738 hCNGA1/var:S320F
UniProtKB:P29973, Ser-320, CHEBI:29997 | UniProtKB:P29973-1, Ser-320, CHEBI:29997 | cGMP-gated cation channel alpha-1 sequence variant 1 (human)
"A cGMP-gated cation channel alpha-1 (human) that has a Phe residue at the position equivalent to Ser-320 of the amino acid sequence represented by UniProtKB:P29973-1. Example: UniProtKB:P29973-1, Ser-320, CHEBI:29997." [PRO:CNA, PRO:DAN]		 associated_with_disease_progressionDO:10584 retinitis pigmentosa PMID:7479749
located_inNOT GO:0005886 plasma membrane PMID:7479749
PR:000036569 cow-CNGA1/iso:1/Phos:1
UniProtKB:Q00194-1, Tyr-498, MOD:00048
"A cGMP-gated cation channel alpha-1 isoform 1 phosphorylated 1 in cow. UniProtKB:Q00194-1, Tyr-498, MOD:00048." [PMID:10366613, PMID:14602825, PRO:CNA]		 enablesdecreased GO:0030553 cGMP binding relative to PR:000002593 PMID:10366613
PR:000045381 cow-CNGA1/iso:1/UnPhos:1
UniProtKB:Q00194-1, Tyr-498, PR:000026291
"A cGMP-gated cation channel alpha-1 isoform 1 (cow) that lacks phosphorylation on Tyr-498. UniProtKB:Q00194-1, Tyr-498, PR:000026291." [PMID:10366613, PRO:CNA]		 enablesGO:0030553 cGMP binding PMID:10366613
PR:P29973-1 hCNGA1/iso:1

"A cGMP-gated cation channel alpha-1 isoform 1 that is encoded in the genome of human." [PRO:CNA]		 located_inGO:0005886 plasma membrane PMID:7479749
PR:P29974 mCNGA1
Cncg | Cncg1 | Cnga1 | CNG channel alpha-1 (mouse) | CNG-1 (mouse) | CNG1 (mouse) | cyclic nucleotide-gated cation channel 1 (mouse) | cyclic nucleotide-gated channel alpha-1 (mouse) | cyclic nucleotide-gated channel, photoreceptor (mouse) | rod photoreceptor cGMP-gated channel subunit alpha (mouse)
"A cGMP-gated cation channel alpha-1 that is encoded in the genome of mouse." [OMA:P29974, PRO:DNx]		 located_inGO:0001750 photoreceptor outer segment PMID:15634774
PR:Q00194-1 cow-CNGA1/iso:1

"A cGMP-gated cation channel alpha-1 isoform 1 that is encoded in the genome of cow." [PRO:CNA]		 located_inGO:0017071 intracellular cyclic nucleotide activated cation channel complex PMID:12432397; PMID:12467591