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Protein Ontology report - voltage-gated potassium channel KCNV2
PR:000000726 -
http://purl.obolibrary.org/obo/PR_000000726
Protein Forms
Annotations
Ontology Information
Show OBO stanza
/
PAF
PRO ID
PR:000000726
PRO name
voltage-gated potassium channel KCNV2
Synonyms
PRO-Short-label
:
EXACT:
KCNV2
Other
:
EXACT:
voltage-gated potassium channel subunit Kv8.2
Definition
"A voltage-gated potassium channel alpha subunit that is a translation product of the human KCNV2 gene or a 1:1 ortholog thereof. Similarly to KCNF1, KCNV1 and KCNS, KCNV2 subunits are not able to form functional channels on their own. Also in common with these modulatory subunits, it lacks the conserved PxP motif located in the distal part of S6. In this class the motif is PIS. The alteration of the PxP motif seems to be an important determinant of the regulatory function of modulatory subunits." [PRO:CNA]
PRO Category
gene
Parent
PR:000000685
Terms by PRO Category
Organism-Independent
Organism-Specific
Category
Number of Terms
Category
Number of Terms
Gene
1
Organism-Gene
2
Sequence
1
Organism-Sequence
7
Modification
0
Organism-Modification
0
Term Hierarchy
Visualization
DAG:
OLS:
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Related Cross References
Db identifiers
IUPHARobj:566
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Protein Forms
Switch to
Extended View
Category
PRO Form Name
Ann.
Has Annotation?
Comp.
In Complex?
gene
PR:000000726
voltage-gated potassium channel KCNV2, KCNV2
Yes
organism-gene
PR:Q8CFS6
potassium voltage-gated channel subfamily V member 2 (mouse), mKCNV2
organism-gene
PR:Q8TDN2
potassium voltage-gated channel subfamily V member 2 (human), hKCNV2
organism-sequence
PR:000000803
voltage-gated potassium channel KCNV2 sequence variant G459D (human), hKCNV2/var:G459D
Yes
organism-sequence
PR:000000804
voltage-gated potassium channel KCNV2 sequence variant A259V (human), hKCNV2/var:A259V
Yes
organism-sequence
PR:000000805
voltage-gated potassium channel KCNV2 sequence variant L126Q (human), hKCNV2/var:L126Q
Yes
organism-sequence
PR:000000806
voltage-gated potassium channel KCNV2 sequence variant 4 (human), hKCNV2/var:4
Yes
organism-sequence
PR:000000807
voltage-gated potassium channel KCNV2 sequence variant S256W (human), hKCNV2/var:S256W
Yes
organism-sequence
PR:000000808
voltage-gated potassium channel KCNV2 sequence variant W188C (human), hKCNV2/var:W188C
Yes
organism-sequence
PR:Q8TDN2-1
potassium voltage-gated channel subfamily V member 2 isoform 1 (human), hKCNV2/iso:1
sequence
PR:000000802
voltage-gated potassium channel KCNV2 isoform 1, KCNV2/iso:1
organism-sequence
PR:Q8TDN2-1
potassium voltage-gated channel subfamily V member 2 isoform 1 (human), hKCNV2/iso:1
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Functional Annotation (PRO-centric view)
Switch to
GO Centric View
PRO Term
GO Annotation
Evidence
PR:000000726
KCNV2
voltage-gated potassium channel subunit Kv8.2
enables
GO:0015459
potassium channel regulator activity
PANTHER:PTHR11537
PR:000000803
hKCNV2/var:G459D
UniProtKB:Q8TDN2, Gly-459, CHEBI:29958 | voltage-gated potassium channel KCNV2 sequence variant 1 (human)
associated_with_disease_progression
DO:0050795
cone dystrophy
PMID:16909397
PR:000000804
hKCNV2/var:A259V
UniProtKB:Q8TDN2, Ala-259, CHEBI:30015 | voltage-gated potassium channel KCNV2 sequence variant 2 (human)
associated_with_disease_progression
DO:0050795
cone dystrophy
PMID:16909397
PR:000000805
hKCNV2/var:L126Q
UniProtKB:Q8TDN2, Leu-126, CHEBI:30011 | voltage-gated potassium channel KCNV2 sequence variant 3 (human)
associated_with_disease_progression
DO:0050795
cone dystrophy
PMID:16909397
PR:000000806
hKCNV2/var:4
UniProtKB:Q8TDN2, 1-338, 342-545
associated_with_disease_progression
DO:0050795
cone dystrophy
PMID:16909397
PR:000000807
hKCNV2/var:S256W
UniProtKB:Q8TDN2, Ser-256, CHEBI:29954 | voltage-gated potassium channel KCNV2 sequence variant 5 (human)
associated_with_disease_progression
DO:0050795
cone dystrophy
PMID:16909397
PR:000000808
hKCNV2/var:W188C
UniProtKB:Q8TDN2, Trp-188, CHEBI:29950 | voltage-gated potassium channel KCNV2 sequence variant 6 (human)
associated_with_disease_progression
DO:0050795
cone dystrophy
PMID:16909397