back to PRO homepage
  Home |   Linked Open Data |   Browse |  
Search

|   Statistics |   Download
 RACE-PRO
 PRO tracker
 Community
 PRO Consortium
 Publications
 Documentation

Protein Ontology report - HLH DNA-binding protein inhibitor
PR:000000003 - http://purl.obolibrary.org/obo/PR_000000003
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza / PAF
  PRO ID
PR:000000003   
  PRO nameHLH DNA-binding protein inhibitor 
  Synonyms
Other: EXACT:DNA-binding protein inhibitor ID
RELATED:ID protein
  Definition"A protein that belongs to the clade D of the bHLH proteins (see PMID:20219281) with a core domain composition consisting of a helix-loop-helix DNA-binding domain (Pfam:PF00010) (HLH), common to the basic HLH family of transcription factors, but lacking the DNA binding domain to the consensus E box response element (CANNTG). By binding to basic HLH transcription factors, proteins in this class regulate gene expression." [PMID:20219281, PRO:CNA] 
  PRO Categoryfamily 
  ParentPR:000000001
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Family1                                                  Organism-Family 0                                        
         Gene4                                                  Organism-Gene 12                                        
         Sequence5                                                  Organism-Sequence 12                                        
         Modification7                                                  Organism-Modification 15                                        
  Term Hierarchy
  Visualization
DAG: OLS:
Back to top
Related Cross References

  Db identifiers
PIRSF:PIRSF005808
Back to top
Protein Forms  Switch to Extended View   

Category  

PRO Form Name

Ann. Has Annotation?

Comp. In Complex?
family



PR:000000003 HLH DNA-binding protein inhibitor, HLH DNA-binding protein inhibitor

Yes

gene



PR:000000039 DNA-binding protein inhibitor ID-1, ID1

Yes

organism-gene



PR:P20067 DNA-binding protein inhibitor ID-1 (mouse), mID1

Yes

organism-sequence



PR:P20067-1 DNA-binding protein inhibitor ID-1 isoform Long (mouse), mID1/iso:Long


organism-sequence



PR:P20067-2 DNA-binding protein inhibitor ID-1 isoform Short (mouse), mID1/iso:Short


organism-gene



PR:P41134 DNA-binding protein inhibitor ID-1 (human), hID1

Yes

organism-sequence



PR:P41134-1 DNA-binding protein inhibitor ID-1 isoform ID-A (human), hID1/iso:ID-A

Yes

organism-sequence



PR:P41134-2 DNA-binding protein inhibitor ID-1 isoform ID-B (human), hID1/iso:ID-B


organism-modification



PR:000071543 DNA-binding protein inhibitor ID-1 cysteinylated 1 (human), hID1/Cyst:1


organism-gene



PR:P41135 DNA-binding protein inhibitor ID-1 (rat), rID1


organism-sequence



PR:P41135-1 DNA-binding protein inhibitor ID-1 isoform Long (rat), rID1/iso:Long


organism-sequence



PR:P41135-2 DNA-binding protein inhibitor ID-1 isoform Short (rat), rID1/iso:Short


sequence



PR:000000171 DNA-binding protein inhibitor ID-1 isoform 1, ID1/iso:1


organism-sequence



PR:P20067-2 DNA-binding protein inhibitor ID-1 isoform Short (mouse), mID1/iso:Short


organism-sequence



PR:P41134-1 DNA-binding protein inhibitor ID-1 isoform ID-A (human), hID1/iso:ID-A

Yes

sequence



PR:000000172 DNA-binding protein inhibitor ID-1 isoform 2, ID1/iso:2


organism-sequence



PR:P41134-2 DNA-binding protein inhibitor ID-1 isoform ID-B (human), hID1/iso:ID-B


gene



PR:000000040 DNA-binding protein inhibitor ID-2, ID2

Yes

organism-gene



PR:P41136 DNA-binding protein inhibitor ID-2 (mouse), mID2


organism-sequence



PR:P41136-1 DNA-binding protein inhibitor ID-2 isoform 1 (mouse), mID2/iso:1

Yes

organism-modification



PR:000045376 DNA-binding protein inhibitor ID-2 isoform 1 unphosphorylated 1 (mouse), mID2/iso:1/UnPhos:1


organism-gene



PR:P41137 DNA-binding protein inhibitor ID-2 (rat), rID2


organism-modification



PR:000036428 DNA-binding protein inhibitor ID-2 isoform 1 phosphorylated 1 (rat), rID2/iso:1/Phos:1

Yes

organism-modification



PR:000045377 DNA-binding protein inhibitor ID-2 isoform 1 unphosphorylated 1 (rat), rID2/iso:1/UnPhos:1

Yes

organism-gene



PR:Q02363 DNA-binding protein inhibitor ID-2 (human), hID2


organism-sequence



PR:Q02363-1 DNA-binding protein inhibitor ID-2 isoform 1 (human), hID2/iso:1


organism-modification



PR:000036427 DNA-binding protein inhibitor ID-2 isoform 1 phosphorylated 1 (human), hID2/iso:1/Phos:1

Yes

organism-modification



PR:000045368 DNA-binding protein inhibitor ID-2 isoform 1 unphosphorylated 1 (human), hID2/iso:1/UnPhos:1

Yes

organism-modification



PR:000069807 DNA-binding protein inhibitor ID-2 sulfated 1 (human), hID2/Sulf:1


organism-modification



PR:000079087 DNA-binding protein inhibitor ID-2 phosphorylated 1 (human), hID2/Phos:1


sequence



PR:000000173 DNA-binding protein inhibitor ID-2 isoform 1, ID2/iso:1


organism-sequence



PR:P41136-1 DNA-binding protein inhibitor ID-2 isoform 1 (mouse), mID2/iso:1

Yes

organism-modification



PR:000045376 DNA-binding protein inhibitor ID-2 isoform 1 unphosphorylated 1 (mouse), mID2/iso:1/UnPhos:1


organism-sequence



PR:Q02363-1 DNA-binding protein inhibitor ID-2 isoform 1 (human), hID2/iso:1


organism-modification



PR:000036427 DNA-binding protein inhibitor ID-2 isoform 1 phosphorylated 1 (human), hID2/iso:1/Phos:1

Yes

organism-modification



PR:000045368 DNA-binding protein inhibitor ID-2 isoform 1 unphosphorylated 1 (human), hID2/iso:1/UnPhos:1

Yes

modification



PR:000000392 DNA-binding protein inhibitor ID-2 isoform 1 phosphorylated form, ID2/iso:1/PhosRes+


modification



PR:000000507 DNA-binding protein inhibitor ID-2 isoform 1 phosphorylated 1, ID2/iso:1/Phos:1


organism-modification



PR:000036427 DNA-binding protein inhibitor ID-2 isoform 1 phosphorylated 1 (human), hID2/iso:1/Phos:1

Yes

organism-modification



PR:000036428 DNA-binding protein inhibitor ID-2 isoform 1 phosphorylated 1 (rat), rID2/iso:1/Phos:1

Yes

modification



PR:000045375 DNA-binding protein inhibitor ID-2 isoform 1 unphosphorylated 1, ID2/iso:1/PhosRes-


organism-modification



PR:000045368 DNA-binding protein inhibitor ID-2 isoform 1 unphosphorylated 1 (human), hID2/iso:1/UnPhos:1

Yes

organism-modification



PR:000045376 DNA-binding protein inhibitor ID-2 isoform 1 unphosphorylated 1 (mouse), mID2/iso:1/UnPhos:1


organism-modification



PR:000045377 DNA-binding protein inhibitor ID-2 isoform 1 unphosphorylated 1 (rat), rID2/iso:1/UnPhos:1

Yes

gene



PR:000000041 DNA-binding protein inhibitor ID-3, ID3

Yes

organism-gene



PR:P41133 DNA-binding protein inhibitor ID-3 (mouse), mID3


organism-sequence



PR:P41133-1 DNA-binding protein inhibitor ID-3 isoform 1 (mouse), mID3/iso:1

Yes

organism-modification



PR:000036430 DNA-binding protein inhibitor ID-3 isoform 1 ubiquitinated 1 (mouse), mID3/iso:1/Ubiq:1

Yes

organism-gene



PR:P41138 DNA-binding protein inhibitor ID-3 (rat), rID3


organism-gene



PR:Q02535 DNA-binding protein inhibitor ID-3 (human), hID3

Yes

organism-sequence



PR:Q02535-1 DNA-binding protein inhibitor ID-3 isoform 1 (human), hID3/iso:1

Yes

organism-modification



PR:000036429 DNA-binding protein inhibitor ID-3 isoform 1 phosphorylated 1 (human), hID3/iso:1/Phos:1

Yes

organism-modification



PR:000064894 DNA-binding protein inhibitor ID-3 methylated 1 (human), hID3/Me:1


organism-modification



PR:000068204 DNA-binding protein inhibitor ID-3 cysteinylated 1 (human), hID3/Cyst:1


organism-modification



PR:000073735 DNA-binding protein inhibitor ID-3 methylated 2 (human), hID3/Me:2


organism-modification



PR:000081463 DNA-binding protein inhibitor ID-3 cysteinylated 2 (human), hID3/Cyst:2


organism-modification



PR:000082453 DNA-binding protein inhibitor ID-3 phosphorylated 1 (human), hID3/Phos:1


sequence



PR:000000174 DNA-binding protein inhibitor ID-3 isoform 1, ID3/iso:1


organism-sequence



PR:P41133-1 DNA-binding protein inhibitor ID-3 isoform 1 (mouse), mID3/iso:1

Yes

organism-modification



PR:000036430 DNA-binding protein inhibitor ID-3 isoform 1 ubiquitinated 1 (mouse), mID3/iso:1/Ubiq:1

Yes

organism-sequence



PR:Q02535-1 DNA-binding protein inhibitor ID-3 isoform 1 (human), hID3/iso:1

Yes

organism-modification



PR:000036429 DNA-binding protein inhibitor ID-3 isoform 1 phosphorylated 1 (human), hID3/iso:1/Phos:1

Yes

modification



PR:000000393 DNA-binding protein inhibitor ID-3 isoform 1 phosphorylated form, ID3/iso:1/PhosRes+


modification



PR:000000508 DNA-binding protein inhibitor ID-3 isoform 1 phosphorylated 1, ID3/iso:1/Phos:1


organism-modification



PR:000036429 DNA-binding protein inhibitor ID-3 isoform 1 phosphorylated 1 (human), hID3/iso:1/Phos:1

Yes

modification



PR:000000394 DNA-binding protein inhibitor ID-3 isoform 1 ubiquitinated form, ID3/iso:1/UbiqLys+


modification



PR:000000509 DNA-binding protein inhibitor ID-3 isoform 1 ubiquitinated 1, ID3/iso:1/Ubiq:1


organism-modification



PR:000036430 DNA-binding protein inhibitor ID-3 isoform 1 ubiquitinated 1 (mouse), mID3/iso:1/Ubiq:1

Yes

gene



PR:000000042 DNA-binding protein inhibitor ID-4, ID4

Yes

organism-gene



PR:P41139 DNA-binding protein inhibitor ID-4 (mouse), mID4


organism-sequence



PR:P41139-1 DNA-binding protein inhibitor ID-4 isoform 1 (mouse), mID4/iso:1

Yes

organism-gene



PR:P47928 DNA-binding protein inhibitor ID-4 (human), hID4


organism-sequence



PR:P47928-1 DNA-binding protein inhibitor ID-4 isoform 1 (human), hID4/iso:1

Yes

organism-gene



PR:Q90X12 helix-loop-helix protein (chicken), chick-ID4


sequence



PR:000000175 DNA-binding protein inhibitor ID-4 isoform 1, ID4/iso:1


organism-sequence



PR:P41139-1 DNA-binding protein inhibitor ID-4 isoform 1 (mouse), mID4/iso:1

Yes

organism-sequence



PR:P47928-1 DNA-binding protein inhibitor ID-4 isoform 1 (human), hID4/iso:1

Yes

Back to top
Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000000003
HLH DNA-binding protein inhibitor
DNA-binding protein inhibitor ID | ID protein | bHLH clade D (BROAD) | bHLH class V (BROAD)
acts_upstream_of_or_withinGO:0006355 regulation of DNA-templated transcription PIRSF:PIRSF005808
enablesGO:0003700 DNA-binding transcription factor activity PIRSF:PIRSF005808
PR:000000039
ID1
BHLHB24 | ID | Id-1 | Idb1 | bHLHb24 | class B basic helix-loop-helix protein 24 | inhibitor of differentiation 1 | inhibitor of DNA binding 1
enablesGO:0046983 protein dimerization activity PANTHER:PTHR11723; PIRSF:PIRSF500477
PR:000000040
ID2
BHLHB26 | Id-2 | Idb2 | bHLHb26 | class B basic helix-loop-helix protein 26 | inhibitor of differentiation 2 | inhibitor of DNA binding 2
acts_upstream_of_or_withinGO:0045892 negative regulation of DNA-templated transcription PIRSF:PIRSF500478
PR:000000041
ID3
1R21 | BHLHB25 | HEIR1 | Hlh462 | Id-3 | Idb3 | bHLHb25 | class B basic helix-loop-helix protein 25 | helix-loop-helix protein HEIR-1 | ID-like protein inhibitor HLH 1R21 | ID-like protein inhibitor HLH 462 | inhibitor of differentiation 3 | inhibitor of DNA binding 3
acts_upstream_of_or_withinGO:0045892 negative regulation of DNA-templated transcription PIRSF:PIRSF500479
PR:000000042
ID4
BHLHB27 | Id-4 | Idb4 | bHLHb27 | class B basic helix-loop-helix protein 27 | inhibitor of differentiation 4 | inhibitor of DNA binding 4
acts_upstream_of_or_withinGO:0045892 negative regulation of DNA-templated transcription PIRSF:PIRSF500478
PR:000036427
hID2/iso:1/Phos:1
UniProtKB:Q02363-1, Ser-5, MOD:00046
acts_upstream_of_or_withinGO:0051726 regulation of cell cycle PMID:9029153
PR:000036428
rID2/iso:1/Phos:1
UniProtKB:P41137-1, Ser-5, MOD:00046
located_inGO:0005634 nucleus PMID:11706002
PR:000036429
hID3/iso:1/Phos:1
UniProtKB:Q02535-1, Ser-5, MOD:00046
acts_upstream_of_or_withinGO:0051726 regulation of cell cycle PMID:9372912
PR:000036430
mID3/iso:1/Ubiq:1
located_inGO:0005737 cytoplasm PMID:15451666
PR:000045368
hID2/iso:1/UnPhos:1
UniProtKB:Q02363-1, Ser-5, PR:000026291
acts_upstream_of_or_withinGO:0045892 negative regulation of DNA-templated transcription PMID:14627819; PMID:9029153
PR:000045377
rID2/iso:1/UnPhos:1
UniProtKB:P41137-1, Ser-5, PR:000026291
located_inGO:0005737 cytoplasm PMID:11706002
PR:P20067
mID1
Id | Id-1 | Id1 | Idb1 | inhibitor of differentiation 1 (mouse) | inhibitor of DNA binding 1 (mouse)
acts_upstream_of_or_withinGO:0000122 negative regulation of transcription by RNA polymerase II PMID:12498716
GO:0030509 BMP signaling pathway PMID:15820682
PR:P41133-1
mID3/iso:1
acts_upstream_of_or_withinGO:0000122 negative regulation of transcription by RNA polymerase II PMID:2000388
located_inGO:0005634 nucleus PMID:15451666
PR:P41134
hID1
BHLHB24 | ID | ID1 | class B basic helix-loop-helix protein 24 (human) | inhibitor of differentiation 1 (human) | inhibitor of DNA binding 1 (human)
acts_upstream_of_or_withinGO:0045892 negative regulation of DNA-templated transcription PMID:15138269
located_inGO:0005634 nucleus PMID:15138269
PR:P41134-1
hID1/iso:ID-A
acts_upstream_of_or_withinGO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction PMID:17855368
enablesGO:0005515 protein binding with PR:Q03135 CAV PMID:17855368
located_inGO:0005737 cytoplasm PMID:17855368
PR:P41136-1
mID2/iso:1
enablesGO:0046983 protein dimerization activity PMID:10891368
located_inGO:0005634 nucleus PMID:12878164
GO:0005737 cytoplasm PMID:12878164; PMID:15563451
PR:P41139-1
mID4/iso:1
acts_upstream_of_or_withinGO:0008284 positive regulation of cell population proliferation PMID:15882580
GO:0030509 BMP signaling pathway PMID:15280210
GO:0045665 negative regulation of neuron differentiation PMID:15882580
GO:0045892 negative regulation of DNA-templated transcription PMID:8139914
enablesGO:0005515 protein binding with PR:Q03135 CAV PMID:15280210
GO:0005515 protein binding with PR:Q9JKN5 mOLIG1 PMID:15280210
located_inGO:0005737 cytoplasm PMID:15280210
PR:P47928-1
hID4/iso:1
acts_upstream_of_or_withinGO:0045892 negative regulation of DNA-templated transcription PMID:11136250
PR:Q02535
hID3
1R21 | BHLHB25 | HEIR1 | ID3 | class B basic helix-loop-helix protein 25 (human) | helix-loop-helix protein HEIR-1 (human) | ID-like protein inhibitor HLH 1R21 (human) | inhibitor of differentiation 3 (human) | inhibitor of DNA binding 3 (human)
acts_upstream_of_or_withinGO:0045892 negative regulation of DNA-templated transcription PMID:14627819
PR:Q02535-1
hID3/iso:1
acts_upstream_of_or_withinGO:0007275 multicellular organism development PMID:1628620
GO:0045892 negative regulation of DNA-templated transcription PMID:8437843
enablesGO:0003714 transcription corepressor activity PMID:8437843