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Documentation
Protein Ontology report - TGF-beta receptor type-2
PR:000000005 -
http://purl.obolibrary.org/obo/PR_000000005
Protein Forms
Complex
Annotations
Ontology Information
Show OBO stanza
/
PAF
PRO ID
PR:000000005
PRO name
TGF-beta receptor type-2
Synonyms
PRO-Short-label
:
EXACT:
TGFBR2
Other
:
EXACT:
TbetaR-II | TGF-beta receptor type II | TGF-beta type II receptor | TGFR-2 | transforming growth factor-beta receptor type II
Definition
"A protein that is a translation product of the human TGFBR2 gene or a 1:1 ortholog thereof." [PRO:CNA]
Comment
The core domain organization is composed of a signal peptide followed by a Transforming growth factor beta receptor 2 ectodomain (
Pfam:PF08917
), a transmembrane domain and a C-terminal Protein kinase domain (
Pfam:PF00069
).
PRO Category
gene
Parent
PR:000000001
Terms by PRO Category
Organism-Independent
Organism-Specific
Category
Number of Terms
Category
Number of Terms
Gene
1
Organism-Gene
4
Sequence
2
Organism-Sequence
21
Modification
7
Organism-Modification
8
Term Hierarchy
Visualization
DAG:
OLS:
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Related Cross References
Db identifiers
PIRSF:PIRSF037393
;
IUPHARobj:1795
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Protein Forms
Switch to
Extended View
Category
PRO Form Name
Ann.
Has Annotation?
Comp.
In Complex?
gene
PR:000000005
TGF-beta receptor type-2, TGFBR2
Yes
organism-gene
PR:P37173
TGF-beta receptor type-2 (human), hTGFBR2
organism-sequence
PR:000000050
TGF-beta receptor type-2 sequence variant L308P (human), hTGFBR2/var:L308P
Yes
organism-sequence
PR:000000051
TGF-beta receptor type-2 sequence variant R460H (human), hTGFBR2/var:R460H
Yes
organism-sequence
PR:000000052
TGF-beta receptor type-2 sequence variant R460C (human), hTGFBR2/var:R460C
Yes
organism-sequence
PR:000000053
TGF-beta receptor type-2 sequence variant E526Q (human), hTGFBR2/var:E526Q
Yes
organism-sequence
PR:000000054
TGF-beta receptor type-2 sequence variant R528C (human), hTGFBR2/var:R528C
Yes
organism-sequence
PR:000000055
TGF-beta receptor type-2 sequence variant R528H (human), hTGFBR2/var:R528H
Yes
organism-sequence
PR:000000056
TGF-beta receptor type-2 sequence variant R537C (human), hTGFBR2/var:R537C
Yes
organism-sequence
PR:000000057
TGF-beta receptor type-2 sequence variant G357W (human), hTGFBR2/var:G357W
Yes
organism-sequence
PR:000000058
TGF-beta receptor type-2 sequence variant T315M (human), hTGFBR2/var:T315M
Yes
organism-sequence
PR:000000059
TGF-beta receptor type-2 sequence variant Y336N (human), hTGFBR2/var:Y336N
Yes
organism-sequence
PR:000000060
TGF-beta receptor type-2 sequence variant A355P (human), hTGFBR2/var:A355P
Yes
organism-sequence
PR:000000061
TGF-beta receptor type-2 sequence variant V387M (human), hTGFBR2/var:V387M
Yes
organism-sequence
PR:000000062
TGF-beta receptor type-2 sequence variant N435S (human), hTGFBR2/var:N435S
Yes
organism-sequence
PR:000000063
TGF-beta receptor type-2 sequence variant V447A (human), hTGFBR2/var:V447A
Yes
organism-sequence
PR:000000064
TGF-beta receptor type-2 sequence variant S449F (human), hTGFBR2/var:S449F
Yes
organism-sequence
PR:000000065
TGF-beta receptor type-2 sequence variant L452M (human), hTGFBR2/var:L452M
Yes
organism-sequence
PR:P37173-1
TGF-beta receptor type-2 isoform RII-1 (human), hTGFBR2/iso:RII-1
organism-modification
PR:000036408
TGF-beta receptor type-2 isoform RII-1, signal peptide removed form (human), hTGFBR2/iso:RII-1/SigPep-
Yes
organism-modification
PR:000025962
TGF-beta receptor type-2 isoform RII-1, signal peptide removed phosphorylated 1 (human), hTGFBR2/iso:RII-1/SigPep-/Phos:1
Yes
organism-sequence
PR:P37173-2
TGF-beta receptor type-2 isoform RII-2 (human), hTGFBR2/iso:RII-2
Yes
organism-sequence
PR:P37173-3
TGF-beta receptor type-2 isoform h3 (human), hTGFBR2/iso:h3
organism-modification
PR:000049434
TGF-beta receptor type-2, signal peptide removed neddylated 1 (human), hTGFBR2/SigPep-/Nedd:1
organism-modification
PR:000060724
TGF-beta receptor type-2 sequence variant Y470D, signal peptide removed form (human), hTGFBR2/var:Y470D/SigPep-
organism-modification
PR:000062611
TGF-beta receptor type-2 sequence variant E526Q, signal peptide removed form (human), hTGFBR2/var:E526Q/SigPep-
organism-modification
PR:000062709
TGF-beta receptor type-2 sequence variant R528C, signal peptide removed form (human), hTGFBR2/var:R528C/SigPep-
organism-modification
PR:000062958
TGF-beta receptor type-2 sequence variant D522N, signal peptide removed form (human), hTGFBR2/var:D522N/SigPep-
organism-modification
PR:000064130
TGF-beta receptor type-2 sequence variant R528H, signal peptide removed form (human), hTGFBR2/var:R528H/SigPep-
organism-gene
PR:P38438
TGF-beta receptor type-2 (rat), rTGFBR2
organism-gene
PR:Q62312
TGF-beta receptor type-2 (mouse), mTGFBR2
organism-sequence
PR:Q62312-1
TGF-beta receptor type-2 isoform RII-2 (mouse), mTGFBR2/iso:RII-2
Yes
organism-sequence
PR:Q62312-2
TGF-beta receptor type-2 isoform RII-1 (mouse), mTGFBR2/iso:RII-1
Yes
organism-gene
PR:Q90999
TGF-beta receptor type-2 (chicken), chick-TGFBR2
sequence
PR:000000048
TGF-beta receptor type-2 isoform RII-1, TGFBR2/iso:RII-1
organism-sequence
PR:P37173-1
TGF-beta receptor type-2 isoform RII-1 (human), hTGFBR2/iso:RII-1
organism-modification
PR:000036408
TGF-beta receptor type-2 isoform RII-1, signal peptide removed form (human), hTGFBR2/iso:RII-1/SigPep-
Yes
organism-modification
PR:000025962
TGF-beta receptor type-2 isoform RII-1, signal peptide removed phosphorylated 1 (human), hTGFBR2/iso:RII-1/SigPep-/Phos:1
Yes
organism-sequence
PR:Q62312-2
TGF-beta receptor type-2 isoform RII-1 (mouse), mTGFBR2/iso:RII-1
Yes
modification
PR:000000198
TGF-beta receptor type-2 isoform RII-1 phosphorylated form, TGFBR2/iso:RII-1/PhosRes+
modification
PR:000000410
TGF-beta receptor type-2 isoform RII-1 phosphorylated 1, TGFBR2/iso:RII-1/Phos:1
modification
PR:000003175
TGF-beta receptor type-2 isoform RII-1, signal peptide removed phosphorylated form, TGFBR2/iso:RII-1/SigPep-/PhosRes+
modification
PR:000003176
TGF-beta receptor type-2 isoform RII-1, signal peptide removed phosphorylated 1, TGFBR2/iso:RII-1/SigPep-/Phos:1
Yes
organism-modification
PR:000025962
TGF-beta receptor type-2 isoform RII-1, signal peptide removed phosphorylated 1 (human), hTGFBR2/iso:RII-1/SigPep-/Phos:1
Yes
modification
PR:000000409
TGF-beta receptor type-2 isoform RII-1, signal peptide removed form, TGFBR2/iso:RII-1/SigPep-
modification
PR:000003175
TGF-beta receptor type-2 isoform RII-1, signal peptide removed phosphorylated form, TGFBR2/iso:RII-1/SigPep-/PhosRes+
modification
PR:000003176
TGF-beta receptor type-2 isoform RII-1, signal peptide removed phosphorylated 1, TGFBR2/iso:RII-1/SigPep-/Phos:1
Yes
organism-modification
PR:000025962
TGF-beta receptor type-2 isoform RII-1, signal peptide removed phosphorylated 1 (human), hTGFBR2/iso:RII-1/SigPep-/Phos:1
Yes
organism-modification
PR:000036408
TGF-beta receptor type-2 isoform RII-1, signal peptide removed form (human), hTGFBR2/iso:RII-1/SigPep-
Yes
organism-modification
PR:000025962
TGF-beta receptor type-2 isoform RII-1, signal peptide removed phosphorylated 1 (human), hTGFBR2/iso:RII-1/SigPep-/Phos:1
Yes
sequence
PR:000000049
TGF-beta receptor type-2 isoform RII-2, TGFBR2/iso:RII-2
organism-sequence
PR:P37173-2
TGF-beta receptor type-2 isoform RII-2 (human), hTGFBR2/iso:RII-2
Yes
organism-sequence
PR:Q62312-1
TGF-beta receptor type-2 isoform RII-2 (mouse), mTGFBR2/iso:RII-2
Yes
modification
PR:000018266
TGF-beta receptor type-2, signal peptide removed form, TGFBR2/SigPep-
modification
PR:000000409
TGF-beta receptor type-2 isoform RII-1, signal peptide removed form, TGFBR2/iso:RII-1/SigPep-
modification
PR:000003175
TGF-beta receptor type-2 isoform RII-1, signal peptide removed phosphorylated form, TGFBR2/iso:RII-1/SigPep-/PhosRes+
modification
PR:000003176
TGF-beta receptor type-2 isoform RII-1, signal peptide removed phosphorylated 1, TGFBR2/iso:RII-1/SigPep-/Phos:1
Yes
organism-modification
PR:000025962
TGF-beta receptor type-2 isoform RII-1, signal peptide removed phosphorylated 1 (human), hTGFBR2/iso:RII-1/SigPep-/Phos:1
Yes
organism-modification
PR:000036408
TGF-beta receptor type-2 isoform RII-1, signal peptide removed form (human), hTGFBR2/iso:RII-1/SigPep-
Yes
organism-modification
PR:000025962
TGF-beta receptor type-2 isoform RII-1, signal peptide removed phosphorylated 1 (human), hTGFBR2/iso:RII-1/SigPep-/Phos:1
Yes
organism-modification
PR:000049434
TGF-beta receptor type-2, signal peptide removed neddylated 1 (human), hTGFBR2/SigPep-/Nedd:1
modification
PR:000025412
TGF-beta receptor type-2 proteolytic cleavage product, TGFBR2/ClvPrd
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TGFBR2
forms found in complexes
TGFBR2
Component
Complexes
PR:000003176
TGFBR2/iso:RII-1/SigPep-/Phos:1
PR:000025976
PR:000025962
hTGFBR2/iso:RII-1/SigPep-/Phos:1
PR:000025963
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Functional Annotation (PRO-centric view)
Switch to
GO Centric View
PRO Term
GO Annotation
Evidence
PR:000000005
TGFBR2
TbetaR-II | TGF-beta receptor type II | TGF-beta type II receptor | TGFR-2 | transforming growth factor-beta receptor type II
acts_upstream_of_or_within
GO:0006468
protein phosphorylation
PIRSF:PIRSF037393
GO:0007179
transforming growth factor beta receptor signaling pathway
PIRSF:PIRSF037393
GO:0042127
regulation of cell population proliferation
PIRSF:PIRSF037393
enables
GO:0004672
protein kinase activity
PIRSF:PIRSF037393
GO:0005515
protein binding
PIRSF:PIRSF037393
PR:000000050
hTGFBR2/var:L308P
UniProtKB:P37173, Leu-308, CHEBI:50342 | UniProtKB:P37173-1, Leu-308, CHEBI:50342 | TGF-beta receptor type-2 sequence variant 1 (human)
associated_with_disease_progression
DO:0050466
Loeys-Dietz syndrome
PMID:15235604
enables
NOT
GO:0005026
transforming growth factor beta receptor activity, type II
PMID:15235604
PR:000000051
hTGFBR2/var:R460H
UniProtKB:P37173, Arg-460, CHEBI:29979 | UniProtKB:P37173-1, Arg-460, CHEBI:29979 | TGF-beta receptor type-2 sequence variant 10 (human)
associated_with_disease_progression
DO:0050466
Loeys-Dietz syndrome
PMID:15731757
PR:000000052
hTGFBR2/var:R460C
UniProtKB:P37173, Arg-460, CHEBI:29950 | UniProtKB:P37173-1, Arg-460, CHEBI:29950 | TGF-beta receptor type-2 sequence variant 11 (human)
associated_with_disease_progression
DO:0050466
Loeys-Dietz syndrome
PMID:15731757
PR:000000053
hTGFBR2/var:E526Q
UniProtKB:P37173, Glu-526, CHEBI:30011 | UniProtKB:P37173-1, Glu-526, CHEBI:30011 | TGF-beta receptor type-2 sequence variant 12 (human)
associated_with_disease_progression
DO:3748
esophagus squamous cell carcinoma
PMID:10789724
enables
NOT
GO:0005026
transforming growth factor beta receptor activity, type II
PMID:10789724
PR:000000054
hTGFBR2/var:R528C
UniProtKB:P37173, Arg-528, CHEBI:29950 | UniProtKB:P37173-1, Arg-528, CHEBI:29950 | TGF-beta receptor type-2 sequence variant 13 (human)
associated_with_disease_progression
DO:0050466
Loeys-Dietz syndrome
PMID:15731757
PR:000000055
hTGFBR2/var:R528H
UniProtKB:P37173, Arg-528, CHEBI:29979 | UniProtKB:P37173-1, Arg-528, CHEBI:29979 | TGF-beta receptor type-2 sequence variant 14 (human)
associated_with_disease_progression
DO:0050466
Loeys-Dietz syndrome
PMID:15731757
PR:000000056
hTGFBR2/var:R537C
UniProtKB:P37173, Arg-537, CHEBI:29950 | UniProtKB:P37173-1, Arg-537, CHEBI:29950 | TGF-beta receptor type-2 sequence variant 15 (human)
associated_with_disease_progression
DO:0050466
Loeys-Dietz syndrome
PMID:15235604
enables
NOT
GO:0005026
transforming growth factor beta receptor activity, type II
PMID:15235604
PR:000000057
hTGFBR2/var:G357W
UniProtKB:P37173, Gly-357, CHEBI:29954 | UniProtKB:P37173-1, Gly-357, CHEBI:29954 | TGF-beta receptor type-2 sequence variant 16 (human)
associated_with_disease_progression
DO:0050466
Loeys-Dietz syndrome
PMID:15731757
PR:000000058
hTGFBR2/var:T315M
UniProtKB:P37173, Thr-315, CHEBI:16044 | UniProtKB:P37173-1, Thr-315, CHEBI:16044 | TGF-beta receptor type-2 sequence variant 2 (human)
acts_upstream_of_or_within
GO:0008284
positive regulation of cell population proliferation
PMID:9590282
associated_with_disease_progression
DO:3883
Lynch syndrome
PMID:9590282
PR:000000059
hTGFBR2/var:Y336N
UniProtKB:P37173, Tyr-336, CHEBI:50347 | UniProtKB:P37173-1, Tyr-336, CHEBI:50347 | TGF-beta receptor type-2 sequence variant 3 (human)
associated_with_disease_progression
DO:0050466
Loeys-Dietz syndrome
PMID:15731757
PR:000000060
hTGFBR2/var:A355P
UniProtKB:P37173, Ala-355, CHEBI:50342 | UniProtKB:P37173-1, Ala-355, CHEBI:50342 | TGF-beta receptor type-2 sequence variant 4 (human)
acts_upstream_of_or_within
GO:0007179
transforming growth factor beta receptor signaling pathway
PMID:15731757
associated_with_disease_progression
DO:0050466
Loeys-Dietz syndrome
PMID:15731757
located_in
GO:0016020
membrane
PMID:15731757
PR:000000061
hTGFBR2/var:V387M
UniProtKB:P37173, Val-387, CHEBI:16044 | UniProtKB:P37173-1, Val-387, CHEBI:16044 | TGF-beta receptor type-2 sequence variant 5 (human)
acts_upstream_of_or_within
GO:0007179
transforming growth factor beta receptor signaling pathway
PMID:11212236
enables
decreased
GO:0005026
transforming growth factor beta receptor activity, type II
relative to
PR:000000409
TGF-beta receptor type-2 isoform 1 cleaved 1
PMID:11212236
located_in
GO:0016020
membrane
PMID:11212236
PR:000000062
hTGFBR2/var:N435S
UniProtKB:P37173, Asn-435, CHEBI:29999 | UniProtKB:P37173-1, Asn-435, CHEBI:29999 | TGF-beta receptor type-2 sequence variant 6 (human)
acts_upstream_of_or_within
GO:0007179
transforming growth factor beta receptor signaling pathway
PMID:11212236
enables
decreased
GO:0005026
transforming growth factor beta receptor activity, type II
relative to
PR:000000409
TGF-beta receptor type-2 isoform 1 cleaved 1
PMID:11212236
PR:000000063
hTGFBR2/var:V447A
UniProtKB:P37173, Val-447, CHEBI:46217 | UniProtKB:P37173-1, Val-447, CHEBI:46217 | TGF-beta receptor type-2 sequence variant 7 (human)
acts_upstream_of_or_within
GO:0007179
transforming growth factor beta receptor signaling pathway
PMID:11212236
enables
decreased
GO:0005026
transforming growth factor beta receptor activity, type II
relative to
PR:000000409
TGF-beta receptor type-2 isoform 1 cleaved 1
PMID:11212236
located_in
GO:0016020
membrane
PMID:11212236
PR:000000064
hTGFBR2/var:S449F
UniProtKB:P37173, Ser-449, CHEBI:29997 | UniProtKB:P37173-1, Ser-449, CHEBI:29997 | TGF-beta receptor type-2 sequence variant 8 (human)
associated_with_disease_progression
DO:0050466
Loeys-Dietz syndrome
PMID:15235604
enables
NOT
GO:0005026
transforming growth factor beta receptor activity, type II
PMID:15235604
PR:000000065
hTGFBR2/var:L452M
UniProtKB:P37173, Leu-452, CHEBI:16044 | UniProtKB:P37173-1, Leu-452, CHEBI:16044 | TGF-beta receptor type-2 sequence variant 9 (human)
acts_upstream_of_or_within
GO:0007179
transforming growth factor beta receptor signaling pathway
PMID:11212236
enables
decreased
GO:0005026
transforming growth factor beta receptor activity, type II
relative to
PR:000000409
TGF-beta receptor type-2 isoform 1 cleaved 1
PMID:11212236
PR:000036408
hTGFBR2/iso:RII-1/SigPep-
UniProtKB:P37173-1, 23-567 | hTGFBR2/iso:1/SigPep- | PRO_0000024426 | TGF-beta receptor type-2 isoform 1, signal peptide removed form (human)
acts_upstream_of_or_within
GO:0007179
transforming growth factor beta receptor signaling pathway
PMID:11483955
GO:0007181
transforming growth factor beta receptor complex assembly
PMID:1310899
;
PMID:8774881
enables
GO:0005026
transforming growth factor beta receptor activity, type II
PMID:11483955
GO:0005515
protein binding
with
PR:000000634
TGFB3/iso:1/Clv:1
PMID:1850637
GO:0005515
protein binding
PMID:1850637
GO:0050431
transforming growth factor beta binding
PMID:11850637
;
PMID:1310899
located_in
GO:0016020
membrane
PMID:1310899
PR:P37173-2
hTGFBR2/iso:RII-2
TGF-beta receptor type-2 isoform 2 (human) | TGFBR2 isoform 2 (human)
acts_upstream_of_or_within
GO:0007179
transforming growth factor beta receptor signaling pathway
PMID:7959019
;
PMID:8635485
GO:0008284
positive regulation of cell population proliferation
PMID:7959019
enables
GO:0005026
transforming growth factor beta receptor activity, type II
PMID:7959019
;
PMID:8635485
GO:0050431
transforming growth factor beta binding
PMID:8635485
PR:Q62312-1
mTGFBR2/iso:RII-2
enables
GO:0050431
transforming growth factor beta binding
PMID:7957954
located_in
GO:0016020
membrane
PMID:7959019
PR:Q62312-2
mTGFBR2/iso:RII-1
located_in
GO:0016020
membrane
PMID:7957954