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Protein Ontology report - cyclin-dependent kinase inhibitor
PR:000000014 - http://purl.obolibrary.org/obo/PR_000000014
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza / PAF
  PRO ID
PR:000000014   
  PRO namecyclin-dependent kinase inhibitor 
  Definition"A protein that has a core domain composition consisting of four ankyrin repeats, and that functions as negative regulator of cyclin-dependent kinases." [PRO:CNA] 
  PRO Categoryfamily 
  ParentPR:000000001 protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Family1                                                  Organism-Family 0                                        
         Gene3                                                  Organism-Gene 7                                        
         Sequence3                                                  Organism-Sequence 10                                        
         Modification2                                                  Organism-Modification 1                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
PIRSF:PIRSF036346
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Ann. Has Annotation?

Comp. In Complex?
family


PR:000000014 cyclin-dependent kinase inhibitor, CHRD
Yes
gene


PR:000000093 cyclin-dependent kinase 4 inhibitor B, CDKN2B
Yes
organism-gene


PR:P42772 cyclin-dependent kinase 4 inhibitor B (human), hCDKN2B

organism-sequence


PR:000000269 cyclin-dependent kinase 4 inhibitor B sequence variant G47E (human), hCDKN2B/var:G47E

organism-sequence


PR:000000270 cyclin-dependent kinase 4 inhibitor B sequence variant A50V (human), hCDKN2B/var:A50V

organism-sequence


PR:P42772-1 cyclin-dependent kinase 4 inhibitor B isoform 1 (human), hCDKN2B/iso:1
Yes
organism-sequence


PR:P42772-2 cyclin-dependent kinase 4 inhibitor B isoform h2 (human), hCDKN2B/iso:h2

organism-gene


PR:P55271 cyclin-dependent kinase 4 inhibitor B (mouse), mCDKN2B

organism-modification


PR:000036455 cyclin-dependent kinase 4 inhibitor B isoform 1 phosphorylated 1 (mouse), mCDKN2B/iso:1/Phos:1

organism-gene


PR:P55272 cyclin-dependent kinase 4 inhibitor B (rat), rCDKN2B

organism-sequence


PR:P55272-1 cyclin-dependent kinase 4 inhibitor B isoform Long (rat), rCDKN2B/iso:Long

organism-sequence


PR:P55272-2 cyclin-dependent kinase 4 inhibitor B isoform Short (rat), rCDKN2B/iso:Short

sequence


PR:000000268 cyclin-dependent kinase 4 inhibitor B isoform 1, CDKN2B/iso:1

organism-sequence


PR:P42772-1 cyclin-dependent kinase 4 inhibitor B isoform 1 (human), hCDKN2B/iso:1
Yes
modification


PR:000000428 cyclin-dependent kinase 4 inhibitor B isoform 1 phosphorylated form, CDKN2B/iso:1/PhosRes+

modification


PR:000000543 cyclin-dependent kinase 4 inhibitor B isoform 1 phosphorylated 1, CDKN2B/iso:1/Phos:1

organism-modification


PR:000036455 cyclin-dependent kinase 4 inhibitor B isoform 1 phosphorylated 1 (mouse), mCDKN2B/iso:1/Phos:1

gene


PR:000005278 cyclin-dependent kinase 4 inhibitor C, CDKN2C

organism-gene


PR:P42773 cyclin-dependent kinase 4 inhibitor C (human), hCDKN2C

organism-sequence


PR:P42773-1 cyclin-dependent kinase 4 inhibitor C isoform 1 (human), hCDKN2C/iso:1

organism-gene


PR:Q60772 cyclin-dependent kinase 4 inhibitor C (mouse), mCDKN2C

organism-sequence


PR:Q60772-1 cyclin-dependent kinase 4 inhibitor C isoform 1 (mouse), mCDKN2C/iso:1

sequence


PR:000039444 cyclin-dependent kinase 4 inhibitor C isoform 1, CDKN2C/iso:1

organism-sequence


PR:P42773-1 cyclin-dependent kinase 4 inhibitor C isoform 1 (human), hCDKN2C/iso:1

organism-sequence


PR:Q60772-1 cyclin-dependent kinase 4 inhibitor C isoform 1 (mouse), mCDKN2C/iso:1

gene


PR:000005279 cyclin-dependent kinase 4 inhibitor D, CDKN2D

organism-gene


PR:P55273 cyclin-dependent kinase 4 inhibitor D (human), hCDKN2D

organism-sequence


PR:P55273-1 cyclin-dependent kinase 4 inhibitor D isoform 1 (human), hCDKN2D/iso:1

organism-gene


PR:Q60773 cyclin-dependent kinase 4 inhibitor D (mouse), mCDKN2D

organism-sequence


PR:Q60773-1 cyclin-dependent kinase 4 inhibitor D isoform 1 (mouse), mCDKN2D/iso:1

sequence


PR:000039795 cyclin-dependent kinase 4 inhibitor D isoform 1, CDKN2D/iso:1

organism-sequence


PR:P55273-1 cyclin-dependent kinase 4 inhibitor D isoform 1 (human), hCDKN2D/iso:1

organism-sequence


PR:Q60773-1 cyclin-dependent kinase 4 inhibitor D isoform 1 (mouse), mCDKN2D/iso:1

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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000000014 CHRD

"A protein that has a core domain composition consisting of four ankyrin repeats, and that functions as negative regulator of cyclin-dependent kinases." [PRO:CNA]		 acts_upstream_of_or_withinGO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity PIRSF:PIRSF036346
GO:0008285 negative regulation of cell population proliferation PIRSF:PIRSF036346
GO:0051726 regulation of cell cycle PIRSF:PIRSF036346
enablesGO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity PIRSF:PIRSF036346
PR:000000093 CDKN2B
MTS2 | MTS-2 | multiple tumor suppressor 2 | p14-INK4b | p15-INK4b | p15INK4B
"A cyclin-dependent kinase inhibitor that is a translation product of the human CDKN2B gene or a 1:1 ortholog thereof." [PRO:CNA]		 acts_upstream_of_or_withinGO:0051726 regulation of cell cycle PANTHER:PTHR24144
PR:P42772-1 hCDKN2B/iso:1
cyclin-dependent kinase 4 inhibitor B isoform p15 (human)
"A cyclin-dependent kinase 4 inhibitor B isoform 1 that is encoded in the genome of human." [PRO:CNA]		 acts_upstream_of_or_withinGO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity PMID:8078588
GO:0008285 negative regulation of cell population proliferation PMID:8078588
GO:0051726 regulation of cell cycle PMID:8078588
enablesGO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity PMID:8078588
GO:0005515 protein binding PMID:16169070