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Protein Ontology report - Myc protein
PR:000000020 - http://purl.obolibrary.org/obo/PR_000000020
 
  Protein Forms  Complex  Annotations      
Ontology Information Show OBO stanza / PAF
  PRO ID
PR:000000020   
  PRO nameMyc protein 
  Synonyms
Other: bHLH clade B (BROAD) | bHLH class III (BROAD)
  Definition"A protein that belongs to the clade B of the bHLH proteins (see PMID:20219281) with a core domain composition consisting of a Myc amino-terminal region (Pfam:PF01056) regulatory domain (known as TAD domain), a helix-loop-helix DNA-binding domain (Pfam:PF00010). Some members such as c-Myc contains an addition C-terminal Myc leucine zipper domain (Pfam:PF02344). Myc proteins participate in the regulation of cell proliferation, cell differentiation, and apoptosis." [PMID:16113099, PMID:16537894, PMID:16543245, PRO:CNA] 
  PRO Categoryfamily 
  ParentPR:000000001 protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Family1                                                  Organism-Family 0                                        
         Gene2                                                  Organism-Gene 9                                        
         Sequence2                                                  Organism-Sequence 13                                        
         Modification10                                                  Organism-Modification 11                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
PIRSF:PIRSF001705
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Ann. Has Annotation?

Comp. In Complex?
family


PR:000000020 Myc protein, IFNG
Yes
gene


PR:000000084 c-myc protein, MYC

organism-gene


PR:P01106 Myc proto-oncogene protein (human), hMYC

Yes
organism-sequence


PR:P01106-1 c-myc protein isoform 1 (human), hMYC/iso:1
Yes
organism-modification


PR:000026033 c-myc protein isoform 1 acetylated 1 (human), hMYC/iso:1/Ac:1
Yes
Yes
organism-modification


PR:000026038 c-myc protein isoform 1 unmodified form (human), hMYC/iso:1/UnMod

Yes
organism-modification


PR:000026041 c-myc protein isoform 1 phosphorylated 4 (human), hMYC/iso:1/Phos:4

organism-modification


PR:000026051 c-myc protein isoform 1 O-glycosylated 1 (human), hMYC/iso:1/OGlyco:1
Yes
organism-modification


PR:000026054 c-myc protein isoform 1 phosphorylated 2 (human), hMYC/iso:1/Phos:2
Yes
organism-modification


PR:000026055 c-myc protein isoform 1 phosphorylated 3 (human), hMYC/iso:1/Phos:3
Yes
organism-modification


PR:000036448 c-myc protein isoform 1 phosphorylated 1 (human), hMYC/iso:1/Phos:1
Yes
organism-sequence


PR:P01106-2 c-myc protein isoform 2 (human), hMYC/iso:2
Yes
organism-sequence


PR:P01106-3 Myc proto-oncogene protein isoform h3 (human), hMYC/iso:h3

organism-modification


PR:000048491 Myc proto-oncogene protein ubiquitinated form (human), hMYC/UbiqLys+

organism-modification


PR:000077803 Myc proto-oncogene protein deaminated 1 (human), hMYC/Deam:1

organism-gene


PR:P01108 Myc proto-oncogene protein (mouse), mMYC

organism-sequence


PR:B2RSN1 c-myc protein isoform 2 (mouse), mMYC/iso:2
Yes
organism-sequence


PR:P01108-1 c-myc protein isoform 1 (mouse), mMYC/iso:1
Yes
organism-modification


PR:000026052 c-myc protein isoform 1 phosphorylated 1 (mouse), mMYC/iso:1/Phos:1
Yes
organism-modification


PR:000026053 c-myc protein isoform 1 phosphorylated 2 (mouse), mMYC/iso:1/Phos:2
Yes
organism-sequence


PR:P01108-2 Myc proto-oncogene protein isoform m1 (mouse), mMYC/iso:m1

organism-sequence


PR:P01108-3 Myc proto-oncogene protein isoform m3 (mouse), mMYC/iso:m3

organism-gene


PR:P01109 Myc proto-oncogene protein (chicken), chick-MYC

organism-sequence


PR:P01109-1 Myc proto-oncogene protein isoform 2 (chicken), chick-MYC/iso:2

organism-sequence


PR:P01109-2 Myc proto-oncogene protein isoform 1 (chicken), chick-MYC/iso:1

organism-gene


PR:P09416 Myc proto-oncogene protein (rat), rMYC

organism-sequence


PR:P09416-1 Myc proto-oncogene protein isoform r2 (rat), rMYC/iso:r2

organism-sequence


PR:P09416-2 Myc proto-oncogene protein isoform r1 (rat), rMYC/iso:r1

organism-gene


PR:P52160 transcriptional regulator Myc-A (zebrafish), z-MYC

organism-sequence


PR:P52160-1 transcriptional regulator Myc-A isoform 2 (zebrafish), z-MYC/iso:2

organism-sequence


PR:P52160-2 transcriptional regulator Myc-A isoform 1 (zebrafish), z-MYC/iso:1

sequence


PR:000000228 c-myc protein isoform 1, MYC/iso:1

organism-sequence


PR:P01106-1 c-myc protein isoform 1 (human), hMYC/iso:1
Yes
organism-modification


PR:000026033 c-myc protein isoform 1 acetylated 1 (human), hMYC/iso:1/Ac:1
Yes
Yes
organism-modification


PR:000026038 c-myc protein isoform 1 unmodified form (human), hMYC/iso:1/UnMod

Yes
organism-modification


PR:000026041 c-myc protein isoform 1 phosphorylated 4 (human), hMYC/iso:1/Phos:4

organism-modification


PR:000026051 c-myc protein isoform 1 O-glycosylated 1 (human), hMYC/iso:1/OGlyco:1
Yes
organism-modification


PR:000026054 c-myc protein isoform 1 phosphorylated 2 (human), hMYC/iso:1/Phos:2
Yes
organism-modification


PR:000026055 c-myc protein isoform 1 phosphorylated 3 (human), hMYC/iso:1/Phos:3
Yes
organism-modification


PR:000036448 c-myc protein isoform 1 phosphorylated 1 (human), hMYC/iso:1/Phos:1
Yes
organism-sequence


PR:P01108-1 c-myc protein isoform 1 (mouse), mMYC/iso:1
Yes
organism-modification


PR:000026052 c-myc protein isoform 1 phosphorylated 1 (mouse), mMYC/iso:1/Phos:1
Yes
organism-modification


PR:000026053 c-myc protein isoform 1 phosphorylated 2 (mouse), mMYC/iso:1/Phos:2
Yes
modification


PR:000000420 c-myc protein isoform 1 acetylated form, MYC/iso:1/AcRes+

modification


PR:000000535 c-myc protein isoform 1 acetylated 1, MYC/iso:1/Ac:1

organism-modification


PR:000026033 c-myc protein isoform 1 acetylated 1 (human), hMYC/iso:1/Ac:1
Yes
Yes
modification


PR:000000421 c-myc protein isoform 1 glycosylated form, MYC/iso:1/GlycoRes+

modification


PR:000000536 c-myc protein isoform 1 O-glycosylated 1, MYC/iso:1/OGlyco:1

organism-modification


PR:000026051 c-myc protein isoform 1 O-glycosylated 1 (human), hMYC/iso:1/OGlyco:1
Yes
modification


PR:000000422 c-myc protein isoform 1 phosphorylated form, MYC/iso:1/PhosRes+

modification


PR:000000537 c-myc protein isoform 1 phosphorylated 1, MYC/iso:1/Phos:1

organism-modification


PR:000026052 c-myc protein isoform 1 phosphorylated 1 (mouse), mMYC/iso:1/Phos:1
Yes
organism-modification


PR:000036448 c-myc protein isoform 1 phosphorylated 1 (human), hMYC/iso:1/Phos:1
Yes
modification


PR:000000538 c-myc protein isoform 1 phosphorylated 2, MYC/iso:1/Phos:2

organism-modification


PR:000026053 c-myc protein isoform 1 phosphorylated 2 (mouse), mMYC/iso:1/Phos:2
Yes
organism-modification


PR:000026054 c-myc protein isoform 1 phosphorylated 2 (human), hMYC/iso:1/Phos:2
Yes
modification


PR:000000539 c-myc protein isoform 1 phosphorylated 3, MYC/iso:1/Phos:3

organism-modification


PR:000026055 c-myc protein isoform 1 phosphorylated 3 (human), hMYC/iso:1/Phos:3
Yes
modification


PR:000026040 c-myc protein isoform 1 phosphorylated 4, MYC/iso:1/Phos:4

organism-modification


PR:000026041 c-myc protein isoform 1 phosphorylated 4 (human), hMYC/iso:1/Phos:4

modification


PR:000002503 c-myc protein isoform 1 unmodified form, MYC/iso:1/UnMod

organism-modification


PR:000026038 c-myc protein isoform 1 unmodified form (human), hMYC/iso:1/UnMod

Yes
sequence


PR:000000229 c-myc protein isoform 2, MYC/iso:2

organism-sequence


PR:B2RSN1 c-myc protein isoform 2 (mouse), mMYC/iso:2
Yes
organism-sequence


PR:P01106-2 c-myc protein isoform 2 (human), hMYC/iso:2
Yes
gene


PR:000010812 N-myc proto-oncogene protein, MYCN

organism-gene


PR:P03966 N-myc proto-oncogene protein (mouse), mMYCN

organism-gene


PR:P04198 N-myc proto-oncogene protein (human), hMYCN

organism-gene


PR:Q63379 N-myc proto-oncogene protein (rat), rMYCN

organism-gene


PR:Q9PSJ0 N-myc protein (zebrafish), z-MYCN

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IFNG forms found in complexes   

IFNG Component
 Complexes
PR:000026033 hMYC/iso:1/Ac:1 PR:000026035 Myc-max acetylated complex (human)
PR:000026038 hMYC/iso:1/UnMod PR:000026039 Myc-max complex 1 (human)
PR:P01106 hMYC PR:000025987 Myc-max complex (human)
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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000000020 IFNG
bHLH clade B (BROAD) | bHLH class III (BROAD)
"A protein that belongs to the clade B of the bHLH proteins (see PMID:20219281) with a core domain composition consisting of a Myc amino-terminal region (Pfam:PF01056) regulatory domain (known as TAD domain), a helix-loop-helix DNA-binding domain (Pfam:PF00010). Some members such as c-Myc contains an addition C-terminal Myc leucine zipper domain (Pfam:PF02344). Myc proteins participate in the regulation of cell proliferation, cell differentiation, and apoptosis." [PMID:16113099, PMID:16537894, PMID:16543245, PRO:CNA]		 acts_upstream_of_or_withinGO:0042127 regulation of cell population proliferation PIRSF:PIRSF001705
enablesGO:0003677 DNA binding PIRSF:PIRSF001705
GO:0005515 protein binding PIRSF:PIRSF001705
PR:000026033 hMYC/iso:1/Ac:1
UniProtKB:P01106-1, Lys-143/Lys-157/Lys-275/Lys-317/Lys-323/Lys-371, MOD:00394
"A c-myc protein isoform 1 acetylated 1 in human. UniProtKB:P01106-1, Lys-143/Lys-157/Lys-275/Lys-317/Lys-323/Lys-371, MOD:00394." [PMID:16126174]		 enablesGO:0003700 DNA-binding transcription factor activity PMID:16126174
located_inGO:0005634 nucleus PMID:16126174
GO:0005667 transcription factor complex PMID:16126174
PR:000026051 hMYC/iso:1/OGlyco:1
UniProtKB:P01106-1, Thr-58, MOD:00806
"A c-myc protein isoform 1 O-glycosylated 1 in human. UniProtKB:P01106-1, Thr-58, MOD:00806." [PMID:11904304, PMID:7642555]		 acts_upstream_of_or_withinGO:0006357 regulation of transcription by RNA polymerase II PMID:11904304
enablesGO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific PMID:11904304
PR:000026052 mMYC/iso:1/Phos:1
UniProtKB:P01108-1, Ser-62, MOD:00046
"A c-myc protein isoform 1 phosphorylated 1 in mouse. UniProtKB:P01108-1, Ser-62, MOD:00046." [PMID:15048125]		 acts_upstream_of_or_withinGO:0006357 regulation of transcription by RNA polymerase II PMID:11018017
GO:0006879 intracellular iron ion homeostasis PMID:11018017
GO:0008283 cell population proliferation PMID:11018017
enablesGO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific PMID:11018017
located_inGO:0005634 nucleus PMID:11018017
GO:0005667 transcription factor complex PMID:11018017
PR:000026053 mMYC/iso:1/Phos:2
UniProtKB:P01108-1, Thr-58, MOD:00047|Ser-62, MOD:00046
"A c-myc protein isoform 1 phosphorylated 2 in mouse. UniProtKB:P01108-1, Thr-58, MOD:00047|Ser-62, MOD:00046." [PMID:14563837, PMID:15503302]		 located_inGO:0005634 nucleus PMID:14563837; PMID:15503302
PR:000026054 hMYC/iso:1/Phos:2
UniProtKB:P01106-1, Thr-58, MOD:00047|Ser-62, MOD:00046
"A c-myc protein isoform 1 phosphorylated 2 in human. UniProtKB:P01106-1, Thr-58, MOD:00047|Ser-62, MOD:00046." [PMID:7623799]		 enablesNOT GO:0003700 DNA-binding transcription factor activity PMID:7623799
PR:000026055 hMYC/iso:1/Phos:3
UniProtKB:P01106-1, Ser-62/Ser-71, MOD:00046
"A c-myc protein isoform 1 phosphorylated 3 in human. UniProtKB:P01106-1, Ser-62/Ser-71, MOD:00046." [PMID:12676581]		 acts_upstream_of_or_withinGO:0045766 positive regulation of angiogenesis PMID:12676581
located_inGO:0005634 nucleus PMID:12676581
PR:000036448 hMYC/iso:1/Phos:1
UniProtKB:P01106-1, Ser-62, MOD:00046
"A c-myc protein isoform 1 phosphorylated 1 in human. UniProtKB:P01106-1, Ser-62, MOD:00046." [PMID:19131971, PRO:CNA]		 enablesGO:0005515 protein binding with PR:O15169-1 PMID:19131971
PR:B2RSN1 mMYC/iso:2

"A c-myc protein isoform 2 that is encoded in the genome of mouse." [PRO:CNA]		 enablescontributes_to GO:0003700 DNA-binding transcription factor activity PMID:7958908
located_inGO:0005667 transcription factor complex PMID:7958908
PR:P01106-1 hMYC/iso:1

"A c-myc protein isoform 1 that is encoded in the genome of human." [PRO:CNA]		 acts_upstream_of_or_withinGO:0006357 regulation of transcription by RNA polymerase II PMID:16908182; PMID:2006410
GO:0008283 cell population proliferation PMID:10962037
GO:0051726 regulation of cell cycle PMID:10962037
enablescontributes_to GO:0003700 DNA-binding transcription factor activity PMID:16908182; PMID:2006410
GO:0005515 protein binding PMID:12706874
located_inGO:0005667 transcription factor complex PMID:16908182; PMID:2006410
PR:P01106-2 hMYC/iso:2

"A c-myc protein isoform 2 that is encoded in the genome of human." [PRO:CNA]		 enablescontributes_to GO:0003700 DNA-binding transcription factor activity PMID:3277717
PR:P01108-1 mMYC/iso:1

"A c-myc protein isoform 1 that is encoded in the genome of mouse." [PRO:CNA]		 located_inGO:0005634 nucleus PMID:15503302; PMID:16908182