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Protein Ontology report - sara-type zinc finger FYVE domain-containing protein
PR:000000026 - http://purl.obolibrary.org/obo/PR_000000026
 
  Protein Forms  Complex  Annotations      
Ontology Information Show OBO stanza / PAF
  PRO ID
PR:000000026   
  PRO namesara-type zinc finger FYVE domain-containing protein 
  Definition"A protein that has a core domain composition consisting of a FYVE zinc finger (Pfam:PF01363) domain and a smad-binding domain that is involved in recruiting and presenting receptor-regulated smads to the receptor complex." [PMID:17356069] 
  PRO Categoryfamily 
  ParentPR:000000001 protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Family1                                                  Organism-Family 0                                        
         Gene2                                                  Organism-Gene 5                                        
         Sequence3                                                  Organism-Sequence 7                                        
         Modification1                                                  Organism-Modification 6                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
PIRSF:PIRSF037289
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Ann. Has Annotation?

Comp. In Complex?
family


PR:000000026 sara-type zinc finger FYVE domain-containing protein, NOG
Yes
gene


PR:000000125 zinc finger FYVE domain-containing protein 9, ZFYVE9
Yes
Yes
organism-gene


PR:000029965 zinc finger FYVE domain-containing protein 9 (mouse), mZFYVE9

organism-sequence


PR:A2A8R0 zinc finger FYVE domain-containing protein 9 isoform 1 (mouse), mZFYVE9/iso:1

organism-sequence


PR:A8Y5G5 zinc finger FYVE domain-containing protein 9 isoform 2 (mouse), mZFYVE9/iso:2

organism-gene


PR:O95405 zinc finger FYVE domain-containing protein 9 (human), hZFYVE9

Yes
organism-sequence


PR:O95405-1 zinc finger FYVE domain-containing protein 9 isoform 1 (human), hZFYVE9/iso:1
Yes
organism-sequence


PR:O95405-2 zinc finger FYVE domain-containing protein 9 isoform 2 (human), hZFYVE9/iso:2
Yes
organism-sequence


PR:O95405-3 zinc finger FYVE domain-containing protein 9 isoform 3 (human), hZFYVE9/iso:3
Yes
sequence


PR:000000313 zinc finger FYVE domain-containing protein 9 isoform 1, ZFYVE9/iso:1

organism-sequence


PR:A2A8R0 zinc finger FYVE domain-containing protein 9 isoform 1 (mouse), mZFYVE9/iso:1

organism-sequence


PR:O95405-1 zinc finger FYVE domain-containing protein 9 isoform 1 (human), hZFYVE9/iso:1
Yes
modification


PR:000002535 zinc finger FYVE domain-containing protein 9 isoform 1 unmodified form, ZFYVE9/iso:1/UnMod

sequence


PR:000000314 zinc finger FYVE domain-containing protein 9 isoform 2, ZFYVE9/iso:2

organism-sequence


PR:A8Y5G5 zinc finger FYVE domain-containing protein 9 isoform 2 (mouse), mZFYVE9/iso:2

organism-sequence


PR:O95405-2 zinc finger FYVE domain-containing protein 9 isoform 2 (human), hZFYVE9/iso:2
Yes
sequence


PR:000000315 zinc finger FYVE domain-containing protein 9 isoform 3, ZFYVE9/iso:3

organism-sequence


PR:O95405-3 zinc finger FYVE domain-containing protein 9 isoform 3 (human), hZFYVE9/iso:3
Yes
gene


PR:000017658 zinc finger FYVE domain-containing protein 16, ZFYVE16

organism-gene


PR:E1C1H1 uncharacterized protein, LOC768418 translation product (chicken), chick-ZFYVE16

organism-gene


PR:Q7Z3T8 zinc finger FYVE domain-containing protein 16 (human), hZFYVE16

organism-sequence


PR:Q7Z3T8-1 zinc finger FYVE domain-containing protein 16 isoform h1 (human), hZFYVE16/iso:h1

organism-sequence


PR:Q7Z3T8-3 zinc finger FYVE domain-containing protein 16 isoform h2 (human), hZFYVE16/iso:h2

organism-modification


PR:000068710 zinc finger FYVE domain-containing protein 16 methylated 1 (human), hZFYVE16/Me:1

organism-modification


PR:000072595 zinc finger FYVE domain-containing protein 16 deaminated 1 (human), hZFYVE16/Deam:1

organism-modification


PR:000074201 zinc finger FYVE domain-containing protein 16 phosphorylated 1 (human), hZFYVE16/Phos:1

organism-modification


PR:000075206 zinc finger FYVE domain-containing protein 16 methylated 2 (human), hZFYVE16/Me:2

organism-modification


PR:000075419 zinc finger FYVE domain-containing protein 16 deaminated 2 (human), hZFYVE16/Deam:2

organism-gene


PR:Q80U44 zinc finger FYVE domain-containing protein 16 (mouse), mZFYVE16

organism-modification


PR:000079565 zinc finger FYVE domain-containing protein 16 cysteinylated 1 (mouse), mZFYVE16/Cyst:1

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NOG forms found in complexes   

NOG Component
 Complexes
PR:000000125 ZFYVE9 PR:000025974 TGF-beta 1:type II receptor:Phospho-type I receptor:SARA:SMAD2 complex
PR:O95405 hZFYVE9 PR:000025965 TGF-beta 1:type II receptor:Phospho-type I receptor:SARA:SMAD2 complex (human)
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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000000026 NOG

"A protein that has a core domain composition consisting of a FYVE zinc finger (Pfam:PF01363) domain and a smad-binding domain that is involved in recruiting and presenting receptor-regulated smads to the receptor complex." [PMID:17356069]		 acts_upstream_of_or_withinGO:0008104 protein localization PIRSF:PIRSF037289
PR:000000125 ZFYVE9
MADHIP | SARA | SMADIP | Madh-interacting protein | mothers against decapentaplegic homolog-interacting protein | novel serine protease | receptor activation anchor | smad anchor for receptor activation | NSP
"A sara-type zinc finger FYVE domain-containing protein that is a translation product of the human ZFYVE9 gene or a 1:1 ortholog thereof." [PRO:CNA]		 acts_upstream_of_or_withinGO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway PANTHER:PTHR22835
PR:O95405-1 hZFYVE9/iso:1

"A zinc finger FYVE domain-containing protein 9 isoform 1 that is encoded in the genome of human." [PRO:CNA]		 acts_upstream_of_or_withinGO:0006897 endocytosis PMID:12809483
GO:0007179 transforming growth factor beta receptor signaling pathway PMID:10615055
GO:0060390 regulation of SMAD protein signal transduction PMID:11877415; PMID:12356868
GO:0060395 SMAD protein signal transduction PMID:11877415; PMID:12356868
enablesGO:0005515 protein binding with PR:000025960 hSMAD2/iso:[Long/Short]/UnPhos:1 PMID:17693260
GO:0005515 protein binding with PR:P08100 hRHO PMID:17693260
located_inGO:0005769 early endosome PMID:11877415; PMID:12356868; PMID:12432064
PR:O95405-2 hZFYVE9/iso:2

"A zinc finger FYVE domain-containing protein 9 isoform 2 that is encoded in the genome of human." [PRO:CNA]		 located_inGO:0005615 extracellular space PMID:9582421
PR:O95405-3 hZFYVE9/iso:3

"A zinc finger FYVE domain-containing protein 9 isoform 3 that is encoded in the genome of human." [PRO:CNA]		 located_inGO:0005615 extracellular space PMID:9582421