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Protein Ontology report - thrombospondin subgroup B
PR:000000030 -
http://purl.obolibrary.org/obo/PR_000000030
Protein Forms
Annotations
Ontology Information
Show OBO stanza
/
PAF
PRO ID
PR:000000030
PRO name
thrombospondin subgroup B
Definition
"A protein that has a core domain composition consisting of three or four EGF-type repeats, a series of seven contiguous calcium-binding repeats (the thrombospondin type 3 repeats), and a globular carboxyl-terminal domain." [
PMID:10842357
]
PRO Category
family
Parent
PR:000000001
protein
Terms by PRO Category
Organism-Independent
Organism-Specific
Category
Number of Terms
Category
Number of Terms
Family
1
Organism-Family
0
Gene
3
Organism-Gene
10
Sequence
3
Organism-Sequence
41
Modification
7
Organism-Modification
13
Term Hierarchy
Visualization
DAG:
OLS:
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Related Cross References
Db identifiers
PIRSF:PIRSF002479
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Protein Forms
Switch to
Extended View
Category
PRO Form Name
Ann.
Has Annotation?
Comp.
In Complex?
family
PR:000000030
thrombospondin subgroup B, NOG
Yes
gene
PR:000000085
cartilage oligomeric matrix protein, COMP
organism-gene
PR:P35444
cartilage oligomeric matrix protein (rat), rCOMP
organism-gene
PR:P49747
cartilage oligomeric matrix protein (human), hCOMP
organism-sequence
PR:000000231
cartilage oligomeric matrix protein sequence variant P276R (human), hCOMP/var:P276R
Yes
organism-sequence
PR:000000232
cartilage oligomeric matrix protein sequence variant C387G (human), hCOMP/var:C387G
Yes
organism-sequence
PR:000000233
cartilage oligomeric matrix protein sequence variant D408Y (human), hCOMP/var:D408Y
Yes
organism-sequence
PR:000000234
cartilage oligomeric matrix protein sequence variant D420A (human), hCOMP/var:D420A
Yes
organism-sequence
PR:000000235
cartilage oligomeric matrix protein sequence variant G440E (human), hCOMP/var:G440E
Yes
organism-sequence
PR:000000236
cartilage oligomeric matrix protein sequence variant G440R (human), hCOMP/var:G440R
Yes
organism-sequence
PR:000000237
cartilage oligomeric matrix protein sequence variant N453S (human), hCOMP/var:N453S
Yes
organism-sequence
PR:000000238
cartilage oligomeric matrix protein sequence variant D439V (human), hCOMP/var:D439V
Yes
organism-sequence
PR:000000239
cartilage oligomeric matrix protein sequence variant C468Y (human), hCOMP/var:C468Y
Yes
organism-sequence
PR:000000240
cartilage oligomeric matrix protein sequence variant D472Y (human), hCOMP/var:D472Y
Yes
organism-sequence
PR:000000241
cartilage oligomeric matrix protein sequence variant D473G (human), hCOMP/var:D473G
Yes
organism-sequence
PR:000000242
cartilage oligomeric matrix protein sequence variant D290N (human), hCOMP/var:D290N
Yes
organism-sequence
PR:000000243
cartilage oligomeric matrix protein sequence variant D482G (human), hCOMP/var:D482G
Yes
organism-sequence
PR:000000244
cartilage oligomeric matrix protein sequence variant D518N (human), hCOMP/var:D518N
Yes
organism-sequence
PR:000000245
cartilage oligomeric matrix protein sequence variant G719D (human), hCOMP/var:G719D
Yes
organism-sequence
PR:000000246
cartilage oligomeric matrix protein sequence variant N523K (human), hCOMP/var:N523K
Yes
organism-sequence
PR:000000247
cartilage oligomeric matrix protein sequence variant T585M (human), hCOMP/var:T585M
Yes
organism-sequence
PR:000000248
cartilage oligomeric matrix protein sequence variant T585R (human), hCOMP/var:T585R
Yes
organism-sequence
PR:000000249
cartilage oligomeric matrix protein sequence variant 26 (human), hCOMP/var:26
Yes
organism-sequence
PR:000000250
cartilage oligomeric matrix protein sequence variant D372del (human), hCOMP/var:D372del
Yes
organism-sequence
PR:000000251
cartilage oligomeric matrix protein sequence variant D374del (human), hCOMP/var:D374del
Yes
organism-sequence
PR:000000252
cartilage oligomeric matrix protein sequence variant S459del (human), hCOMP/var:S459del
Yes
organism-sequence
PR:000000253
cartilage oligomeric matrix protein sequence variant G299R (human), hCOMP/var:G299R
Yes
organism-sequence
PR:000000254
cartilage oligomeric matrix protein sequence variant D469del (human), hCOMP/var:D469del
Yes
organism-sequence
PR:000000255
cartilage oligomeric matrix protein sequence variant D473del (human), hCOMP/var:D473del
Yes
organism-sequence
PR:000000256
cartilage oligomeric matrix protein sequence variant 32 (human), hCOMP/var:32
Yes
organism-sequence
PR:000000257
cartilage oligomeric matrix protein sequence variant 33 (human), hCOMP/var:33
Yes
organism-sequence
PR:000000258
cartilage oligomeric matrix protein sequence variant C328R (human), hCOMP/var:C328R
Yes
organism-sequence
PR:000000259
cartilage oligomeric matrix protein sequence variant D342Y (human), hCOMP/var:D342Y
Yes
organism-sequence
PR:000000260
cartilage oligomeric matrix protein sequence variant C348R (human), hCOMP/var:C348R
Yes
organism-sequence
PR:000000261
cartilage oligomeric matrix protein sequence variant D361V (human), hCOMP/var:D361V
Yes
organism-sequence
PR:000000262
cartilage oligomeric matrix protein sequence variant D361Y (human), hCOMP/var:D361Y
Yes
organism-sequence
PR:000000263
cartilage oligomeric matrix protein sequence variant C371S (human), hCOMP/var:C371S
Yes
organism-sequence
PR:P49747-1
cartilage oligomeric matrix protein isoform 1 (human), hCOMP/iso:1
Yes
organism-modification
PR:000036452
cartilage oligomeric matrix protein isoform 1, signal peptide removed form (human), hCOMP/iso:1/SigPep-
Yes
organism-sequence
PR:P49747-2
cartilage oligomeric matrix protein isoform h2 (human), hCOMP/iso:h2
organism-modification
PR:000056586
cartilage oligomeric matrix protein N-glycosylated 1 (human), hCOMP/NGlyco:1
organism-modification
PR:000056587
cartilage oligomeric matrix protein N-glycosylated 2 (human), hCOMP/NGlyco:2
organism-modification
PR:000068189
cartilage oligomeric matrix protein deaminated 1 (human), hCOMP/Deam:1
organism-modification
PR:000073868
cartilage oligomeric matrix protein deaminated 2 (human), hCOMP/Deam:2
organism-gene
PR:Q9R0G6
cartilage oligomeric matrix protein (mouse), mCOMP
organism-sequence
PR:Q9R0G6-1
cartilage oligomeric matrix protein isoform 1 (mouse), mCOMP/iso:1
sequence
PR:000000230
cartilage oligomeric matrix protein isoform 1, COMP/iso:1
organism-sequence
PR:P49747-1
cartilage oligomeric matrix protein isoform 1 (human), hCOMP/iso:1
Yes
organism-modification
PR:000036452
cartilage oligomeric matrix protein isoform 1, signal peptide removed form (human), hCOMP/iso:1/SigPep-
Yes
organism-sequence
PR:Q9R0G6-1
cartilage oligomeric matrix protein isoform 1 (mouse), mCOMP/iso:1
modification
PR:000000540
cartilage oligomeric matrix protein isoform 1, signal peptide removed form, COMP/iso:1/SigPep-
organism-modification
PR:000036452
cartilage oligomeric matrix protein isoform 1, signal peptide removed form (human), hCOMP/iso:1/SigPep-
Yes
modification
PR:000025416
cartilage oligomeric matrix protein proteolytic cleavage product, COMP/ClvPrd
gene
PR:000000131
thrombospondin-3, THBS3
organism-gene
PR:P49746
thrombospondin-3 (human), hTHBS3
organism-sequence
PR:P49746-1
thrombospondin-3 isoform 1 (human), hTHBS3/iso:1
organism-sequence
PR:P49746-2
thrombospondin-3 isoform h2 (human), hTHBS3/iso:h2
organism-modification
PR:000049438
thrombospondin-3, signal peptide removed form (human), hTHBS3/SigPep-
organism-modification
PR:000056585
thrombospondin-3 N-glycosylated 1 (human), hTHBS3/NGlyco:1
organism-gene
PR:Q05895
thrombospondin-3 (mouse), mTHBS3
organism-sequence
PR:Q05895-1
thrombospondin-3 isoform 1 (mouse), mTHBS3/iso:1
organism-modification
PR:000036494
thrombospondin-3 isoform 1, signal peptide removed form (mouse), mTHBS3/iso:1/SigPep-
Yes
organism-gene
PR:Q8JHW2
thrombospondin-3a (zebrafish), z-THBS3
sequence
PR:000000378
thrombospondin-3 isoform 1, THBS3/iso:1
organism-sequence
PR:P49746-1
thrombospondin-3 isoform 1 (human), hTHBS3/iso:1
organism-sequence
PR:Q05895-1
thrombospondin-3 isoform 1 (mouse), mTHBS3/iso:1
organism-modification
PR:000036494
thrombospondin-3 isoform 1, signal peptide removed form (mouse), mTHBS3/iso:1/SigPep-
Yes
modification
PR:000000594
thrombospondin-3 isoform 1, signal peptide removed form, THBS3/iso:1/SigPep-
organism-modification
PR:000036494
thrombospondin-3 isoform 1, signal peptide removed form (mouse), mTHBS3/iso:1/SigPep-
Yes
modification
PR:000018284
thrombospondin-3, signal peptide removed form, THBS3/SigPep-
modification
PR:000000594
thrombospondin-3 isoform 1, signal peptide removed form, THBS3/iso:1/SigPep-
organism-modification
PR:000036494
thrombospondin-3 isoform 1, signal peptide removed form (mouse), mTHBS3/iso:1/SigPep-
Yes
organism-modification
PR:000049438
thrombospondin-3, signal peptide removed form (human), hTHBS3/SigPep-
modification
PR:000025439
thrombospondin-3 proteolytic cleavage product, THBS3/ClvPrd
gene
PR:000000132
thrombospondin-4, THBS4
organism-gene
PR:P35443
thrombospondin-4 (human), hTHBS4
organism-sequence
PR:P35443-1
thrombospondin-4 isoform 1 (human), hTHBS4/iso:1
organism-modification
PR:000026337
thrombospondin-4 isoform 1, signal peptide removed form (human), hTHBS4/iso:1/SigPep-
Yes
organism-modification
PR:000056389
thrombospondin-4 O-glycosylated 1 (human), hTHBS4/OGlyco:1
organism-modification
PR:000056390
thrombospondin-4 O-glycosylated 2 (human), hTHBS4/OGlyco:2
organism-modification
PR:000056391
thrombospondin-4 O-glycosylated 3 (human), hTHBS4/OGlyco:3
organism-modification
PR:000056392
thrombospondin-4 O-glycosylated 4 (human), hTHBS4/OGlyco:4
organism-gene
PR:P49744
thrombospondin-4 (rat), rTHBS4
organism-gene
PR:Q8JGW0
thrombospondin-4-B (zebrafish), z-THBS4
organism-gene
PR:Q9Z1T2
thrombospondin-4 (mouse), mTHBS4
organism-sequence
PR:Q9Z1T2-1
thrombospondin-4 isoform 1 (mouse), mTHBS4/iso:1
sequence
PR:000000379
thrombospondin-4 isoform 1, THBS4/iso:1
organism-sequence
PR:P35443-1
thrombospondin-4 isoform 1 (human), hTHBS4/iso:1
organism-modification
PR:000026337
thrombospondin-4 isoform 1, signal peptide removed form (human), hTHBS4/iso:1/SigPep-
Yes
organism-sequence
PR:Q9Z1T2-1
thrombospondin-4 isoform 1 (mouse), mTHBS4/iso:1
modification
PR:000000595
thrombospondin-4 isoform 1, signal peptide removed form, THBS4/iso:1/SigPep-
organism-modification
PR:000026337
thrombospondin-4 isoform 1, signal peptide removed form (human), hTHBS4/iso:1/SigPep-
Yes
modification
PR:000025440
thrombospondin-4 proteolytic cleavage product, THBS4/ClvPrd
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Functional Annotation (PRO-centric view)
Switch to
GO Centric View
PRO Term
GO Annotation
Evidence
PR:000000030
NOG
"A protein that has a core domain composition consisting of three or four EGF-type repeats, a series of seven contiguous calcium-binding repeats (the thrombospondin type 3 repeats), and a globular carboxyl-terminal domain." [PMID:10842357]
enables
GO:0008201
heparin binding
PIRSF:PIRSF002479
PR:000000231
hCOMP/var:P276R
UniProtKB:P49747, Pro-276, CHEBI:29952 | UniProtKB:P49747-1, Pro-276, CHEBI:29952 | cartilage oligomeric matrix protein sequence variant 1 (human)
"A cartilage oligomeric matrix protein (human) that has an Arg residue at the position equivalent to Pro-276 of the amino acid sequence represented by UniProtKB:P49747-1. Example: UniProtKB:P49747-1, Pro-276, CHEBI:29952." [PMID:11565064, PRO:CNA, PRO:DAN]
associated_with_disease_progression
DO:12721
multiple epiphyseal dysplasia
PMID:11565064
PR:000000232
hCOMP/var:C387G
UniProtKB:P49747, Cys-387, CHEBI:29947 | UniProtKB:P49747-1, Cys-387, CHEBI:29947 | cartilage oligomeric matrix protein sequence variant 10 (human)
"A cartilage oligomeric matrix protein (human) that has a Gly residue at the position equivalent to Cys-387 of the amino acid sequence represented by UniProtKB:P49747-1. Example: UniProtKB:P49747-1, Cys-387, CHEBI:29947." [PRO:CNA, PRO:DAN]
associated_with_disease_progression
DO:0080047
pseudoachondroplasia
UniProtKB_VAR:VAR_007625
PR:000000233
hCOMP/var:D408Y
UniProtKB:P49747, Asp-408, CHEBI:46858 | UniProtKB:P49747-1, Asp-408, CHEBI:46858 | cartilage oligomeric matrix protein sequence variant 11 (human)
"A cartilage oligomeric matrix protein (human) that has a Tyr residue at the position equivalent to Asp-408 of the amino acid sequence represented by UniProtKB:P49747-1. Example: UniProtKB:P49747-1, Asp-408, CHEBI:46858." [PMID:9452026, PRO:CNA, PRO:DAN]
associated_with_disease_progression
DO:12721
multiple epiphyseal dysplasia
PMID:9452026
PR:000000234
hCOMP/var:D420A
UniProtKB:P49747, Asp-420, CHEBI:46217 | UniProtKB:P49747-1, Asp-420, CHEBI:46217 | cartilage oligomeric matrix protein sequence variant 12 (human)
"A cartilage oligomeric matrix protein (human) that has an Ala residue at the position equivalent to Asp-420 of the amino acid sequence represented by UniProtKB:P49747-1. Example: UniProtKB:P49747-1, Asp-420, CHEBI:46217." [PMID:11565064, PRO:CNA, PRO:DAN]
associated_with_disease_progression
DO:12721
multiple epiphyseal dysplasia
PMID:11565064
PR:000000235
hCOMP/var:G440E
UniProtKB:P49747, Gly-440, CHEBI:29972 | UniProtKB:P49747-1, Gly-440, CHEBI:29972 | cartilage oligomeric matrix protein sequence variant 13 (human)
"A cartilage oligomeric matrix protein (human) that has a Glu residue at the position equivalent to Gly-440 of the amino acid sequence represented by UniProtKB:P49747-1. Example: UniProtKB:P49747-1, Gly-440, CHEBI:29972." [PRO:CNA, PRO:DAN]
associated_with_disease_progression
DO:0080047
pseudoachondroplasia
UniProtKB_VAR:VAR_007628
PR:000000236
hCOMP/var:G440R
UniProtKB:P49747, Gly-440, CHEBI:29952 | UniProtKB:P49747-1, Gly-440, CHEBI:29952 | cartilage oligomeric matrix protein sequence variant 14 (human)
"A cartilage oligomeric matrix protein (human) that has an Arg residue at the position equivalent to Gly-440 of the amino acid sequence represented by UniProtKB:P49747-1. Example: UniProtKB:P49747-1, Gly-440, CHEBI:29952." [PMID:9452026, PRO:CNA, PRO:DAN]
associated_with_disease_progression
DO:0080047
pseudoachondroplasia
PMID:9452026
PR:000000237
hCOMP/var:N453S
UniProtKB:P49747, Asn-453, CHEBI:29999 | UniProtKB:P49747-1, Asn-453, CHEBI:29999 | cartilage oligomeric matrix protein sequence variant 15 (human)
"A cartilage oligomeric matrix protein (human) that has a Ser residue at the position equivalent to Asn-453 of the amino acid sequence represented by UniProtKB:P49747-1. Example: UniProtKB:P49747-1, Asn-453, CHEBI:29999." [PRO:CNA, PRO:DAN]
associated_with_disease_progression
DO:12721
multiple epiphyseal dysplasia
UniProtKB_VAR:VAR_007630
PR:000000238
hCOMP/var:D439V
UniProtKB:P49747, Asp-439, CHEBI:30015 | UniProtKB:P49747-1, Asp-439, CHEBI:30015 | cartilage oligomeric matrix protein sequence variant 16 (human)
"A cartilage oligomeric matrix protein (human) that has a Val residue at the position equivalent to Asp-439 of the amino acid sequence represented by UniProtKB:P49747-1. Example: UniProtKB:P49747-1, Asp-439, CHEBI:30015." [PRO:CNA, PRO:DAN]
associated_with_disease_progression
DO:0080047
pseudoachondroplasia
UniProtKB_VAR:VAR_007618
PR:000000239
hCOMP/var:C468Y
UniProtKB:P49747, Cys-468, CHEBI:46858 | UniProtKB:P49747-1, Cys-468, CHEBI:46858 | cartilage oligomeric matrix protein sequence variant 17 (human)
"A cartilage oligomeric matrix protein (human) that has a Tyr residue at the position equivalent to Cys-468 of the amino acid sequence represented by UniProtKB:P49747-1. Example: UniProtKB:P49747-1, Cys-468, CHEBI:46858." [PMID:7670471, PMID:9452026, PRO:CNA, PRO:DAN]
associated_with_disease_progression
DO:0080047
pseudoachondroplasia
PMID:7670471
;
PMID:9452026
PR:000000240
hCOMP/var:D472Y
UniProtKB:P49747, Asp-472, CHEBI:46858 | UniProtKB:P49747-1, Asp-472, CHEBI:46858 | cartilage oligomeric matrix protein sequence variant 18 (human)
"A cartilage oligomeric matrix protein (human) that has a Tyr residue at the position equivalent to Asp-472 of the amino acid sequence represented by UniProtKB:P49747-1. Example: UniProtKB:P49747-1, Asp-472, CHEBI:46858." [PMID:7670471, PMID:9452026, PRO:CNA, PRO:DAN]
associated_with_disease_progression
DO:0080047
pseudoachondroplasia
PMID:7670471
;
PMID:9452026
PR:000000241
hCOMP/var:D473G
UniProtKB:P49747, Asp-473, CHEBI:29947 | UniProtKB:P49747-1, Asp-473, CHEBI:29947 | cartilage oligomeric matrix protein sequence variant 19 (human)
"A cartilage oligomeric matrix protein (human) that has a Gly residue at the position equivalent to Asp-473 of the amino acid sequence represented by UniProtKB:P49747-1. Example: UniProtKB:P49747-1, Asp-473, CHEBI:29947." [PRO:CNA, PRO:DAN]
associated_with_disease_progression
DO:0080047
pseudoachondroplasia
UniProtKB_VAR:VAR_007635
PR:000000242
hCOMP/var:D290N
UniProtKB:P49747, Asp-290, CHEBI:50347 | UniProtKB:P49747-1, Asp-290, CHEBI:50347 | cartilage oligomeric matrix protein sequence variant 2 (human)
"A cartilage oligomeric matrix protein (human) that has an Asn residue at the position equivalent to Asp-290 of the amino acid sequence represented by UniProtKB:P49747-1. Example: UniProtKB:P49747-1, Asp-290, CHEBI:50347." [PRO:CNA, PRO:DAN]
associated_with_disease_progression
DO:0080047
pseudoachondroplasia
UniProtKB_VAR:VAR_007614
PR:000000243
hCOMP/var:D482G
UniProtKB:P49747, Asp-482, CHEBI:29947 | UniProtKB:P49747-1, Asp-482, CHEBI:29947 | cartilage oligomeric matrix protein sequence variant 20 (human)
"A cartilage oligomeric matrix protein (human) that has a Gly residue at the position equivalent to Asp-482 of the amino acid sequence represented by UniProtKB:P49747-1. Example: UniProtKB:P49747-1, Asp-482, CHEBI:29947." [PMID:9452063, PRO:CNA, PRO:DAN]
associated_with_disease_progression
DO:0080047
pseudoachondroplasia
PMID:9452063
PR:000000244
hCOMP/var:D518N
UniProtKB:P49747, Asp-518, CHEBI:50347 | UniProtKB:P49747-1, Asp-518, CHEBI:50347 | cartilage oligomeric matrix protein sequence variant 21 (human)
"A cartilage oligomeric matrix protein (human) that has an Asn residue at the position equivalent to Asp-518 of the amino acid sequence represented by UniProtKB:P49747-1. Example: UniProtKB:P49747-1, Asp-518, CHEBI:50347." [PRO:CNA, PRO:DAN]
associated_with_disease_progression
DO:0080047
pseudoachondroplasia
UniProtKB_VAR:VAR_007639
PR:000000245
hCOMP/var:G719D
UniProtKB:P49747, Gly-719, CHEBI:29958 | UniProtKB:P49747-1, Gly-719, CHEBI:29958 | cartilage oligomeric matrix protein sequence variant 22 (human)
"A cartilage oligomeric matrix protein (human) that has an Asp residue at the position equivalent to Gly-719 of the amino acid sequence represented by UniProtKB:P49747-1. Example: UniProtKB:P49747-1, Gly-719, CHEBI:29958." [PMID:11746044, PRO:CNA, PRO:DAN]
associated_with_disease_progression
DO:0080047
pseudoachondroplasia
PMID:11746044
PR:000000246
hCOMP/var:N523K
UniProtKB:P49747, Asn-523, CHEBI:29967 | UniProtKB:P49747-1, Asn-523, CHEBI:29967 | cartilage oligomeric matrix protein sequence variant 23 (human)
"A cartilage oligomeric matrix protein (human) that has a Lys residue at the position equivalent to Asn-523 of the amino acid sequence represented by UniProtKB:P49747-1. Example: UniProtKB:P49747-1, Asn-523, CHEBI:29967." [PMID:9021009, PRO:CNA, PRO:DAN]
associated_with_disease_progression
DO:12721
multiple epiphyseal dysplasia
PMID:9021009
PR:000000247
hCOMP/var:T585M
UniProtKB:P49747, Thr-585, CHEBI:16044 | UniProtKB:P49747-1, Thr-585, CHEBI:16044 | cartilage oligomeric matrix protein sequence variant 24 (human)
"A cartilage oligomeric matrix protein (human) that has a Met residue at the position equivalent to Thr-585 of the amino acid sequence represented by UniProtKB:P49747-1. Example: UniProtKB:P49747-1, Thr-585, CHEBI:16044." [PMID:11565064, PRO:CNA, PRO:DAN]
associated_with_disease_progression
DO:0080047
pseudoachondroplasia
PMID:11565064
DO:12721
multiple epiphyseal dysplasia
PMID:11565064
PR:000000248
hCOMP/var:T585R
UniProtKB:P49747, Thr-585, CHEBI:29952 | UniProtKB:P49747-1, Thr-585, CHEBI:29952 | cartilage oligomeric matrix protein sequence variant 25 (human)
"A cartilage oligomeric matrix protein (human) that has an Arg residue at the position equivalent to Thr-585 of the amino acid sequence represented by UniProtKB:P49747-1. Example: UniProtKB:P49747-1, Thr-585, CHEBI:29952." [PRO:CNA, PRO:DAN]
associated_with_disease_progression
DO:12721
multiple epiphyseal dysplasia
UniProtKB_VAR:VAR_007642
PR:000000249
hCOMP/var:26
"A cartilage oligomeric matrix protein (human) that has a Val residue at the position equivalent to region 391-394 of the amino acid sequence represented by UniProtKB:P49747-1." [PRO:CNA, PRO:DAN]
associated_with_disease_progression
DO:0080047
pseudoachondroplasia
UniProtKB_VAR:VAR_007626
PR:000000250
hCOMP/var:D372del
UniProtKB:P49747, 21-371, 373-757 | UniProtKB:P49747-1, 21-371, 373-757 | cartilage oligomeric matrix protein sequence variant 27 (human)
"A cartilage oligomeric matrix protein (human) that has a single-residue deletion at the position equivalent to Asp-372 of the amino acid sequence represented by UniProtKB:P49747-1. Example: UniProtKB:P49747-1, 21-371, 373-757." [PRO:CNA, PRO:DAN]
associated_with_disease_progression
DO:0080047
pseudoachondroplasia
UniProtKB_VAR:VAR_007623
PR:000000251
hCOMP/var:D374del
UniProtKB:P49747, 21-373, 375-757 | UniProtKB:P49747-1, 21-373, 375-757 | cartilage oligomeric matrix protein sequence variant 28 (human)
"A cartilage oligomeric matrix protein (human) that has a single-residue deletion at the position equivalent to Asp-374 of the amino acid sequence represented by UniProtKB:P49747-1. Example: UniProtKB:P49747-1, 21-373, 375-757." [PRO:CNA, PRO:DAN]
associated_with_disease_progression
DO:0080047
pseudoachondroplasia
UniProtKB_VAR:VAR_007624
PR:000000252
hCOMP/var:S459del
UniProtKB:P49747, 21-458, 460-757 | UniProtKB:P49747-1, 21-458, 460-757 | cartilage oligomeric matrix protein sequence variant 29 (human)
"A cartilage oligomeric matrix protein (human) that has a single-residue deletion at the position equivalent to Ser-459 of the amino acid sequence represented by UniProtKB:P49747-1. Example: UniProtKB:P49747-1, 21-458, 460-757." [PRO:CNA, PRO:DAN]
associated_with_disease_progression
DO:0080047
pseudoachondroplasia
UniProtKB_VAR:VAR_007631
PR:000000253
hCOMP/var:G299R
UniProtKB:P49747, Gly-299, CHEBI:29952 | UniProtKB:P49747-1, Gly-299, CHEBI:29952 | cartilage oligomeric matrix protein sequence variant 3 (human)
"A cartilage oligomeric matrix protein (human) that has an Arg residue at the position equivalent to Gly-299 of the amino acid sequence represented by UniProtKB:P49747-1. Example: UniProtKB:P49747-1, Gly-299, CHEBI:29952." [PRO:CNA, PRO:DAN]
associated_with_disease_progression
DO:0080047
pseudoachondroplasia
UniProtKB_VAR:VAR_007615
PR:000000254
hCOMP/var:D469del
UniProtKB:P49747, 21-468, 470-757 | UniProtKB:P49747-1, 21-468, 470-757 | cartilage oligomeric matrix protein sequence variant 30 (human)
"A cartilage oligomeric matrix protein (human) that has a single-residue deletion at the position equivalent to Asp-469 of the amino acid sequence represented by UniProtKB:P49747-1. Example: UniProtKB:P49747-1, 21-468, 470-757." [PRO:CNA, PRO:DAN]
associated_with_disease_progression
DO:0080047
pseudoachondroplasia
UniProtKB_VAR:VAR_007633
PR:000000255
hCOMP/var:D473del
UniProtKB:P49747, 21-472, 474-757 | UniProtKB:P49747-1, 21-472, 474-757 | cartilage oligomeric matrix protein sequence variant 31 (human)
"A cartilage oligomeric matrix protein (human) that has a single-residue deletion at the position equivalent to Asp-473 of the amino acid sequence represented by UniProtKB:P49747-1. Example: UniProtKB:P49747-1, 21-472, 474-757." [PRO:CNA, PRO:DAN]
associated_with_disease_progression
DO:0080047
pseudoachondroplasia
UniProtKB_VAR:VAR_007636
PR:000000256
hCOMP/var:32
UniProtKB:P49747, 21-366, 369-757 | UniProtKB:P49747-1, 21-366, 369-757
"A cartilage oligomeric matrix protein (human) that has a two-residue deletion at the positions equivalent to region 367-368 of the amino acid sequence represented by UniProtKB:P49747-1. Example: UniProtKB:P49747-1, 21-366, 369-757." [PRO:CNA, PRO:DAN]
associated_with_disease_progression
DO:12721
multiple epiphyseal dysplasia
UniProtKB_VAR:VAR_007621
PR:000000257
hCOMP/var:33
UniProtKB:P49747, 21-512, 517-757 | UniProtKB:P49747-1, 21-512, 517-757
"A cartilage oligomeric matrix protein (human) that has a four-residue deletion at the positions equivalent to region 513-516 of the amino acid sequence represented by UniProtKB:P49747-1. Example: UniProtKB:P49747-1, 21-512, 517-757." [PRO:CNA, PRO:DAN]
associated_with_disease_progression
DO:0080047
pseudoachondroplasia
UniProtKB_VAR:VAR_007638
PR:000000258
hCOMP/var:C328R
UniProtKB:P49747, Cys-328, CHEBI:29952 | UniProtKB:P49747-1, Cys-328, CHEBI:29952 | cartilage oligomeric matrix protein sequence variant 4 (human)
"A cartilage oligomeric matrix protein (human) that has an Arg residue at the position equivalent to Cys-328 of the amino acid sequence represented by UniProtKB:P49747-1. Example: UniProtKB:P49747-1, Cys-328, CHEBI:29952." [PRO:CNA, PRO:DAN]
associated_with_disease_progression
DO:0080047
pseudoachondroplasia
UniProtKB_VAR:VAR_007616
PR:000000259
hCOMP/var:D342Y
UniProtKB:P49747, Asp-342, CHEBI:46858 | UniProtKB:P49747-1, Asp-342, CHEBI:46858 | cartilage oligomeric matrix protein sequence variant 5 (human)
"A cartilage oligomeric matrix protein (human) that has a Tyr residue at the position equivalent to Asp-342 of the amino acid sequence represented by UniProtKB:P49747-1. Example: UniProtKB:P49747-1, Asp-342, CHEBI:46858." [PMID:7670472, PMID:9452026, PRO:CNA, PRO:DAN]
associated_with_disease_progression
DO:12721
multiple epiphyseal dysplasia
PMID:7670472
;
PMID:9452026
PR:000000260
hCOMP/var:C348R
UniProtKB:P49747, Cys-348, CHEBI:29952 | UniProtKB:P49747-1, Cys-348, CHEBI:29952 | cartilage oligomeric matrix protein sequence variant 6 (human)
"A cartilage oligomeric matrix protein (human) that has an Arg residue at the position equivalent to Cys-348 of the amino acid sequence represented by UniProtKB:P49747-1. Example: UniProtKB:P49747-1, Cys-348, CHEBI:29952." [PMID:11746045, PRO:CNA, PRO:DAN]
associated_with_disease_progression
DO:0080047
pseudoachondroplasia
PMID:11746045
PR:000000261
hCOMP/var:D361V
UniProtKB:P49747, Asp-361, CHEBI:30015 | UniProtKB:P49747-1, Asp-361, CHEBI:30015 | cartilage oligomeric matrix protein sequence variant 7 (human)
"A cartilage oligomeric matrix protein (human) that has a Val residue at the position equivalent to Asp-361 of the amino acid sequence represented by UniProtKB:P49747-1. Example: UniProtKB:P49747-1, Asp-361, CHEBI:30015." [PRO:CNA, PRO:DAN]
associated_with_disease_progression
DO:12721
multiple epiphyseal dysplasia
UniProtKB_VAR:VAR_007619
PR:000000262
hCOMP/var:D361Y
UniProtKB:P49747, Asp-361, CHEBI:46858 | UniProtKB:P49747-1, Asp-361, CHEBI:46858 | cartilage oligomeric matrix protein sequence variant 8 (human)
"A cartilage oligomeric matrix protein (human) that has a Tyr residue at the position equivalent to Asp-361 of the amino acid sequence represented by UniProtKB:P49747-1. Example: UniProtKB:P49747-1, Asp-361, CHEBI:46858." [PMID:9452027, PRO:CNA, PRO:DAN]
associated_with_disease_progression
DO:12721
multiple epiphyseal dysplasia
PMID:9452026
PR:000000263
hCOMP/var:C371S
UniProtKB:P49747, Cys-371, CHEBI:29999 | UniProtKB:P49747-1, Cys-371, CHEBI:29999 | cartilage oligomeric matrix protein sequence variant 9 (human)
"A cartilage oligomeric matrix protein (human) that has a Ser residue at the position equivalent to Cys-371 of the amino acid sequence represented by UniProtKB:P49747-1. Example: UniProtKB:P49747-1, Cys-371, CHEBI:29999." [PMID:9184241, PRO:CNA, PRO:DAN]
associated_with_disease_progression
DO:12721
multiple epiphyseal dysplasia
PMID:9184241
PR:000026337
hTHBS4/iso:1/SigPep-
UniProtKB:P35443-1, 27-961 | PRO_0000035852
"A thrombospondin-4 isoform 1, signal peptide removed form in human. UniProtKB:P35443-1, 27-961." [PRO:DNx, UniProtKB:P35443]
acts_upstream_of_or_within
GO:0006930
substrate-dependent cell migration, cell extension
PMID:7490284
enables
GO:0005509
calcium ion binding
PMID:7852353
GO:0008201
heparin binding
PMID:7852353
located_in
GO:0031012
extracellular matrix
PMID:7490284
PR:000036452
hCOMP/iso:1/SigPep-
UniProtKB:P49747-1, 21-757 | PRO_0000035857
"A cartilage oligomeric matrix protein isoform 1, signal peptide removed form in human. UniProtKB:P49747-1, 21-757." [PMID:7670472, PMID:7713493, PMID:9749943, PRO:CNA]
acts_upstream_of_or_within
GO:0009887
animal organ morphogenesis
PMID:7713493
enables
GO:0005201
extracellular matrix structural constituent
PMID:9749943
GO:0005509
calcium ion binding
PMID:7670472
located_in
GO:0031012
extracellular matrix
PMID:9749943
PR:000036494
mTHBS3/iso:1/SigPep-
UniProtKB:Q05895-1, 22-956 | PRO_0000035850
"A thrombospondin-3 isoform 1, signal peptide removed form in mouse. UniProtKB:Q05895-1, 22-956." [PMID:7759526, PMID:8288588, PMID:8468055, PRO:CNA]
acts_upstream_of_or_within
GO:0007160
cell-matrix adhesion
PMID:8468055
enables
GO:0005509
calcium ion binding
PMID:8288588
GO:0008201
heparin binding
PMID:8288588
GO:0042802
identical protein binding
PMID:7759526
located_in
GO:0005615
extracellular space
PMID:8288588
PR:P49747-1
hCOMP/iso:1
"A cartilage oligomeric matrix protein isoform 1 that is encoded in the genome of human." [PRO:CNA]
acts_upstream_of_or_within
GO:0001501
skeletal system development
PMID:7670472
GO:0009887
animal organ morphogenesis
PMID:7713493
