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Protein Ontology report - BMP receptor type-1B

PR:000000036 - http://purl.obolibrary.org/obo/PR_000000036

Protein Forms

Annotations

Ontology Information

Show OBO stanza

PRO ID

PR:000000036

PRO name

BMP receptor type-1B

Synonyms

PRO-Short-label:	EXACT:	BMPR1B
Gene-based:	RELATED:	Acvrlk6
Other:	EXACT:	activin receptor-like kinase 6 \| ALK-6 \| BMP type-1B receptor \| BMPR-1B \| CDw293 \| serine/threonine-protein kinase receptor R6 \| SKR6

Definition

"A TGF-beta superfamily receptor type-1 that is a translation product of the human BMPR1B gene or a 1:1 ortholog thereof. Bone morphogenetic protein (BMP) signals are transmitted by type 2 and type 1 serine/threonine kinase receptors. Type 2 receptors phosphorylate and activate type 1 receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMPS/OP-1." [PRO:CNA]

PRO Category

gene

Parent

PR:000000006

Terms by PRO Category

Organism-Independent		Organism-Specific
Category	Number of Terms	Category	Number of Terms
Gene	1	Organism-Gene	5
Sequence	1	Organism-Sequence	5
Modification	2	Organism-Modification	4

Term Hierarchy
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OLS:

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Related Cross References
Db identifiers	IUPHARobj:1789

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Protein Forms

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Category

PRO Form Name

Ann. Has Annotation?

Comp. In Complex?

gene

PR:000000036 BMP receptor type-1B, BMPR1B

organism-gene

PR:O00238 bone morphogenetic protein receptor type-1B (human), hBMPR1B

organism-sequence

PR:000000146 BMP receptor type-1B sequence variant I200K (human), hBMPR1B/var:I200K

Yes

organism-sequence

PR:000000147 BMP receptor type-1B sequence variant R486W (human), hBMPR1B/var:R486W

Yes

organism-sequence

PR:O00238-1 bone morphogenetic protein receptor type-1B isoform 1 (human), hBMPR1B/iso:1

Yes

organism-modification

PR:000036426 BMP receptor type-1B isoform 1 phosphorylated 1 (human), hBMPR1B/iso:1/Phos:1

Yes

organism-sequence

PR:O00238-2 bone morphogenetic protein receptor type-1B isoform h2 (human), hBMPR1B/iso:h2

organism-modification

PR:000046495 bone morphogenetic protein receptor type-1B, signal peptide removed form (human), hBMPR1B/SigPep-

organism-modification

PR:000046496 bone morphogenetic protein receptor type-1B, signal peptide removed phosphoserine form (human), hBMPR1B/SigPep-/PhosSer+

organism-modification

PR:000046496 bone morphogenetic protein receptor type-1B, signal peptide removed phosphoserine form (human), hBMPR1B/SigPep-/PhosSer+

organism-gene

PR:P36898 bone morphogenetic protein receptor type-1B (mouse), mBMPR1B

organism-sequence

PR:P36898-1 bone morphogenetic protein receptor type-1B isoform 1 (mouse), mBMPR1B/iso:1

Yes

organism-modification

PR:000036425 BMP receptor type-1B isoform 1 phosphorylated 1 (mouse), mBMPR1B/iso:1/Phos:1

Yes

organism-gene

PR:Q05438 bone morphogenetic protein receptor type-1B (chicken), chick-BMPR1B

organism-gene

PR:Q09488 serine/threonine-protein kinase receptor sma-6 (worm), BMPR1B (worm)

organism-gene

PR:Q569A5 receptor protein serine/threonine kinase (rat), rBMPR1B

sequence

PR:000000145 BMP receptor type-1B isoform 1, BMPR1B/iso:1

organism-sequence

PR:O00238-1 bone morphogenetic protein receptor type-1B isoform 1 (human), hBMPR1B/iso:1

Yes

organism-modification

PR:000036426 BMP receptor type-1B isoform 1 phosphorylated 1 (human), hBMPR1B/iso:1/Phos:1

Yes

organism-sequence

PR:P36898-1 bone morphogenetic protein receptor type-1B isoform 1 (mouse), mBMPR1B/iso:1

Yes

organism-modification

PR:000036425 BMP receptor type-1B isoform 1 phosphorylated 1 (mouse), mBMPR1B/iso:1/Phos:1

Yes

modification

PR:000000383 BMP receptor type-1B isoform 1 phosphorylated form, BMPR1B/iso:1/PhosRes+

modification

PR:000000500 BMP receptor type-1B isoform 1 phosphorylated 1, BMPR1B/iso:1/Phos:1

organism-modification

PR:000036425 BMP receptor type-1B isoform 1 phosphorylated 1 (mouse), mBMPR1B/iso:1/Phos:1

Yes

organism-modification

PR:000036426 BMP receptor type-1B isoform 1 phosphorylated 1 (human), hBMPR1B/iso:1/Phos:1

Yes

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Functional Annotation (PRO-centric view)

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PRO Term	GO Annotation		Evidence
PR:000000146 hBMPR1B/var:I200K UniProtKB:O00238, Ile-200, CHEBI:29967 \| UniProtKB:O00238-1, Ile-200, CHEBI:29967 \| BMP receptor type-1B sequence variant 1 (human)	associated_with_disease_progression	DO:0050581 brachydactyly	PMID:14523231
	enables	NOT GO:0004674 protein serine/threonine kinase activity	PMID:14523231
	located_in	GO:0009986 cell surface	PMID:14523231
PR:000000147 hBMPR1B/var:R486W UniProtKB:O00238, Arg-486, CHEBI:29954 \| UniProtKB:O00238-1, Arg-486, CHEBI:29954 \| BMP receptor type-1B sequence variant 2 (human)	associated_with_disease_progression	DO:0050581 brachydactyly	PMID:14523231
	enables	GO:0004674 protein serine/threonine kinase activity	PMID:14523231
	located_in	GO:0009986 cell surface	PMID:14523231
PR:000036425 mBMPR1B/iso:1/Phos:1	acts_upstream_of_or_within	GO:0001501 skeletal system development	PMID:14523231
		GO:0001502 cartilage condensation	PMID:10631181; PMID:14523231
		GO:0035108 limb morphogenesis	PMID:14523231
	located_in	GO:0009986 cell surface	PMID:10712517; PMID:14523231
	located_in	GO:0043235 receptor complex	PMID:10712517
PR:000036426 hBMPR1B/iso:1/Phos:1	acts_upstream_of_or_within	GO:0030509 BMP signaling pathway	PMID:10051328
PR:000036426 hBMPR1B/iso:1/Phos:1	acts_upstream_of_or_within	GO:0045597 positive regulation of cell differentiation	PMID:14523231
PR:O00238-1 hBMPR1B/iso:1	acts_upstream_of_or_within	GO:0030509 BMP signaling pathway	PMID:10051328
PR:P36898-1 mBMPR1B/iso:1	acts_upstream_of_or_within	GO:0001501 skeletal system development	PMID:14523231
		GO:0001502 cartilage condensation	PMID:14523231
		GO:0035108 limb morphogenesis	PMID:14523231
	located_in	GO:0009986 cell surface	PMID:10712517