back to PRO homepage
  Home |   Linked Open Data |   Browse |  
Search

 |   Statistics |   Download
 RACE-PRO
 PRO tracker
 Community
 PRO Consortium
 Publications
 Documentation

Protein Ontology report - BMP receptor type-2
PR:000000037 - http://purl.obolibrary.org/obo/PR_000000037
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza / PAF
  PRO ID
PR:000000037   
  PRO nameBMP receptor type-2 
  Synonyms
PRO-Short-label: EXACT:BMPR2
Gene-based: RELATED:PPH1
Other: EXACT:BMP type II receptor | BMP type-2 receptor | BMPR-2 | BMPR-II | bone morphogenetic protein receptor type II | BRK-3
  Definition"A TGF-beta superfamily receptor type-2 with activin receptor domain that is a translation product of the human BMPR2 gene or a 1:1 ortholog thereof. Bone morphogenetic protein (BMP) signals are transmitted by type 2 and type 1 serine/threonine kinase receptors. Type 2 receptors phosphorylate and activate type 1 receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators." [PRO:CNA] 
  PRO Categorygene 
  ParentPR:000000007
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 2                                        
         Sequence1                                                  Organism-Sequence 17                                        
         Modification0                                                  Organism-Modification 7                                        
  Term Hierarchy
  Visualization
DAG: OLS:
Back to top
Related Cross References

  Db identifiers
PIRSF:PIRSF500434;IUPHARobj:1794
Back to top
Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Ann. Has Annotation?

Comp. In Complex?
gene


PR:000000037 BMP receptor type-2, BMPR2
Yes
organism-gene


PR:O35607 bone morphogenetic protein receptor type-2 (mouse), mBMPR2

organism-sequence


PR:O35607-1 bone morphogenetic protein receptor type-2 isoform 1 (mouse), mBMPR2/iso:1
Yes
organism-gene


PR:Q13873 bone morphogenetic protein receptor type-2 (human), hBMPR2

organism-sequence


PR:000000149 BMP receptor type-2 sequence variant C60Y (human), hBMPR2/var:C60Y
Yes
organism-sequence


PR:000000150 BMP receptor type-2 sequence variant D485G (human), hBMPR2/var:D485G
Yes
organism-sequence


PR:000000151 BMP receptor type-2 sequence variant R491Q (human), hBMPR2/var:R491Q
Yes
organism-sequence


PR:000000152 BMP receptor type-2 sequence variant R491W (human), hBMPR2/var:R491W
Yes
organism-sequence


PR:000000153 BMP receptor type-2 sequence variant K512T (human), hBMPR2/var:K512T
Yes
organism-sequence


PR:000000154 BMP receptor type-2 sequence variant N519K (human), hBMPR2/var:N519K
Yes
organism-sequence


PR:000000155 BMP receptor type-2 sequence variant C117Y (human), hBMPR2/var:C117Y
Yes
organism-sequence


PR:000000156 BMP receptor type-2 sequence variant C118W (human), hBMPR2/var:C118W
Yes
organism-sequence


PR:000000157 BMP receptor type-2 sequence variant C123R (human), hBMPR2/var:C123R
Yes
organism-sequence


PR:000000158 BMP receptor type-2 sequence variant C123S (human), hBMPR2/var:C123S
Yes
organism-sequence


PR:000000159 BMP receptor type-2 sequence variant E224D (human), hBMPR2/var:E224D
Yes
organism-sequence


PR:000000160 BMP receptor type-2 sequence variant C347Y (human), hBMPR2/var:C347Y
Yes
organism-sequence


PR:000000161 BMP receptor type-2 sequence variant C420R (human), hBMPR2/var:C420R
Yes
organism-sequence


PR:000000162 BMP receptor type-2 sequence variant C483R (human), hBMPR2/var:C483R
Yes
organism-sequence


PR:Q13873-1 bone morphogenetic protein receptor type-2 isoform 1 (human), hBMPR2/iso:1
Yes
organism-sequence


PR:Q13873-2 bone morphogenetic protein receptor type-2 isoform h2 (human), hBMPR2/iso:h2

organism-modification


PR:000046497 bone morphogenetic protein receptor type-2, signal peptide removed form (human), hBMPR2/SigPep-

organism-modification


PR:000057061 bone morphogenetic protein receptor type-2 N-glycosylated 1 (human), hBMPR2/NGlyco:1

organism-modification


PR:000057062 bone morphogenetic protein receptor type-2 O-glycosylated 1 (human), hBMPR2/OGlyco:1

organism-modification


PR:000065377 bone morphogenetic protein receptor type-2 methylated 1 (human), hBMPR2/Me:1

organism-modification


PR:000065967 bone morphogenetic protein receptor type-2 deaminated 1 (human), hBMPR2/Deam:1

organism-modification


PR:000073289 bone morphogenetic protein receptor type-2 deaminated 2 (human), hBMPR2/Deam:2

organism-modification


PR:000081621 bone morphogenetic protein receptor type-2 deaminated 3 (human), hBMPR2/Deam:3

sequence


PR:000000148 BMP receptor type-2 isoform 1, BMPR2/iso:1

organism-sequence


PR:O35607-1 bone morphogenetic protein receptor type-2 isoform 1 (mouse), mBMPR2/iso:1
Yes
organism-sequence


PR:Q13873-1 bone morphogenetic protein receptor type-2 isoform 1 (human), hBMPR2/iso:1
Yes
Back to top
Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000000037
BMPR2
PPH1 | BMP type II receptor | BMP type-2 receptor | BMPR-2 | BMPR-II | bone morphogenetic protein receptor type II | BRK-3		 acts_upstream_of_or_withinGO:0030509 BMP signaling pathway PIRSF:PIRSF500434
PR:000000149
hBMPR2/var:C60Y
UniProtKB:Q13873, Cys-60, CHEBI:46858 | UniProtKB:Q13873-1, Cys-60, CHEBI:46858 | BMP receptor type-2 sequence variant 1 (human)		 associated_with_disease_progressionDO:14557 primary pulmonary hypertension PMID:11015450
PR:000000150
hBMPR2/var:D485G
UniProtKB:Q13873, Asp-485, CHEBI:29947 | UniProtKB:Q13873-1, Asp-485, CHEBI:29947 | BMP receptor type-2 sequence variant 10 (human)		 associated_with_disease_progressionDO:14557 primary pulmonary hypertension PMID:10973254
PR:000000151
hBMPR2/var:R491Q
UniProtKB:Q13873, Arg-491, CHEBI:30011 | UniProtKB:Q13873-1, Arg-491, CHEBI:30011 | BMP receptor type-2 sequence variant 11 (human)		 associated_with_disease_progressionDO:14557 primary pulmonary hypertension PMID:10903931
PR:000000152
hBMPR2/var:R491W
UniProtKB:Q13873, Arg-491, CHEBI:29954 | UniProtKB:Q13873-1, Arg-491, CHEBI:29954 | BMP receptor type-2 sequence variant 12 (human)		 associated_with_disease_progressionDO:14557 primary pulmonary hypertension PMID:10903931
PR:000000153
hBMPR2/var:K512T
UniProtKB:Q13873, Lys-512, CHEBI:30013 | UniProtKB:Q13873-1, Lys-512, CHEBI:30013 | BMP receptor type-2 sequence variant 13 (human)		 associated_with_disease_progressionDO:14557 primary pulmonary hypertension PMID:11115378
PR:000000154
hBMPR2/var:N519K
UniProtKB:Q13873, Asn-519, CHEBI:29967 | UniProtKB:Q13873-1, Asn-519, CHEBI:29967 | BMP receptor type-2 sequence variant 14 (human)		 associated_with_disease_progressionDO:14557 primary pulmonary hypertension UniProtKB_VAR:VAR_013683
PR:000000155
hBMPR2/var:C117Y
UniProtKB:Q13873, Cys-117, CHEBI:46858 | UniProtKB:Q13873-1, Cys-117, CHEBI:46858 | BMP receptor type-2 sequence variant 2 (human)		 associated_with_disease_progressionDO:14557 primary pulmonary hypertension PMID:11015450
PR:000000156
hBMPR2/var:C118W
UniProtKB:Q13873, Cys-118, CHEBI:29954 | UniProtKB:Q13873-1, Cys-118, CHEBI:29954 | BMP receptor type-2 sequence variant 3 (human)		 associated_with_disease_progressionDO:14557 primary pulmonary hypertension PMID:10973254
PR:000000157
hBMPR2/var:C123R
UniProtKB:Q13873, Cys-123, CHEBI:29952 | UniProtKB:Q13873-1, Cys-123, CHEBI:29952 | BMP receptor type-2 sequence variant 4 (human)		 associated_with_disease_progressionDO:14557 primary pulmonary hypertension PMID:11115378
PR:000000158
hBMPR2/var:C123S
UniProtKB:Q13873, Cys-123, CHEBI:29999 | UniProtKB:Q13873-1, Cys-123, CHEBI:29999 | BMP receptor type-2 sequence variant 5 (human)		 associated_with_disease_progressionDO:14557 primary pulmonary hypertension PMID:11115378
PR:000000159
hBMPR2/var:E224D
UniProtKB:Q13873, Glu-224, CHEBI:29958 | UniProtKB:Q13873-1, Glu-224, CHEBI:29958 | BMP receptor type-2 sequence variant 6 (human)		 associated_with_disease_progressionDO:14557 primary pulmonary hypertension PMID:11115378
PR:000000160
hBMPR2/var:C347Y
UniProtKB:Q13873, Cys-347, CHEBI:46858 | UniProtKB:Q13873-1, Cys-347, CHEBI:46858 | BMP receptor type-2 sequence variant 7 (human)		 associated_with_disease_progressionDO:14557 primary pulmonary hypertension PMID:10973254
PR:000000161
hBMPR2/var:C420R
UniProtKB:Q13873, Cys-420, CHEBI:29952 | UniProtKB:Q13873-1, Cys-420, CHEBI:29952 | BMP receptor type-2 sequence variant 8 (human)		 associated_with_disease_progressionDO:14557 primary pulmonary hypertension PMID:11115378
PR:000000162
hBMPR2/var:C483R
UniProtKB:Q13873, Cys-483, CHEBI:29952 | UniProtKB:Q13873-1, Cys-483, CHEBI:29952 | BMP receptor type-2 sequence variant 9 (human)		 associated_with_disease_progressionDO:14557 primary pulmonary hypertension PMID:11015450; PMID:12358323
PR:O35607-1
mBMPR2/iso:1
 acts_upstream_of_or_withinGO:0030509 BMP signaling pathway PMID:12117821
located_inGO:0009986 cell surface PMID:12117821
PR:Q13873-1
hBMPR2/iso:1
 acts_upstream_of_or_withinGO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway PMID:7644468
enablesGO:0005515 protein binding with PR:P12643 BMP-2 (human) PMID:7791754
GO:0005515 protein binding with PR:P18075 BMP-7 (human) PMID:7791754
located_inGO:0005886 plasma membrane PMID:7791754
GO:0009986 cell surface PMID:10712517
GO:0043235 receptor complex PMID:7791754