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Protein Ontology report - BMP receptor-regulated smad protein
PR:000000038 - http://purl.obolibrary.org/obo/PR_000000038
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza / PAF
  PRO ID
PR:000000038   
  PRO nameBMP receptor-regulated smad protein 
  Synonyms
PRO-Short-label: EXACT:R-SMAD(BMP)
  Definition"A smad protein that mediates signal transduction through activation of bone morphogenetic protein (BMP) or anti-Mullerian hormone pathways." [PMID:11532220] 
  PRO Categoryfamily 
  ParentPR:000000027 smad protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Family1                                                  Organism-Family 0                                        
         Gene3                                                  Organism-Gene 11                                        
         Sequence5                                                  Organism-Sequence 10                                        
         Modification13                                                  Organism-Modification 14                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
PIRSF:PIRSF500500
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Ann. Has Annotation?

Comp. In Complex?
family


PR:000000038 BMP receptor-regulated smad protein, R-SMAD(BMP)
Yes
gene


PR:000000363 smad1, SMAD1

organism-gene


PR:P70340 mothers against decapentaplegic homolog 1 (mouse), mSMAD1

organism-sequence


PR:P70340-1 mothers against decapentaplegic homolog 1 isoform 1 (mouse), mSMAD1/iso:1
Yes
organism-modification


PR:000026724 smad1 isoform 1 phosphorylated 1 (mouse), mSMAD1/iso:1/Phos:1
Yes
organism-gene


PR:P97588 mothers against decapentaplegic homolog 1 (rat), rSMAD1

organism-gene


PR:Q15797 mothers against decapentaplegic homolog 1 (human), hSMAD1

organism-sequence


PR:Q15797-1 mothers against decapentaplegic homolog 1 isoform 1 (human), hSMAD1/iso:1
Yes
organism-modification


PR:000026334 smad1 isoform 1 phosphorylated 1 (human), hSMAD1/iso:1/Phos:1
Yes
organism-modification


PR:000036553 smad1 isoform 1 phosphorylated and ubiquitinated 1 (human), hSMAD1/iso:1/PhosUbiq:1
Yes
organism-sequence


PR:Q15797-2 mothers against decapentaplegic homolog 1 isoform h2 (human), hSMAD1/iso:h2

organism-modification


PR:000049280 mothers against decapentaplegic homolog 1 ubiquitinated form (human), hSMAD1/UbiqLys+

organism-modification


PR:000036553 smad1 isoform 1 phosphorylated and ubiquitinated 1 (human), hSMAD1/iso:1/PhosUbiq:1
Yes
organism-modification


PR:000050147 smad1 phosphorylated 1 (human), hSMAD1/Phos:1

sequence


PR:000000467 smad1 isoform 1, SMAD1/iso:1

organism-sequence


PR:P70340-1 mothers against decapentaplegic homolog 1 isoform 1 (mouse), mSMAD1/iso:1
Yes
organism-modification


PR:000026724 smad1 isoform 1 phosphorylated 1 (mouse), mSMAD1/iso:1/Phos:1
Yes
organism-sequence


PR:Q15797-1 mothers against decapentaplegic homolog 1 isoform 1 (human), hSMAD1/iso:1
Yes
organism-modification


PR:000026334 smad1 isoform 1 phosphorylated 1 (human), hSMAD1/iso:1/Phos:1
Yes
organism-modification


PR:000036553 smad1 isoform 1 phosphorylated and ubiquitinated 1 (human), hSMAD1/iso:1/PhosUbiq:1
Yes
modification


PR:000000570 smad1 isoform 1 phosphorylated and ubiquitinated form, SMAD1/iso:1/PhosUbiq+

modification


PR:000000648 smad1 isoform 1 phosphorylated and ubiquitinated 1, SMAD1/iso:1/PhosUbiq:1

organism-modification


PR:000036553 smad1 isoform 1 phosphorylated and ubiquitinated 1 (human), hSMAD1/iso:1/PhosUbiq:1
Yes
modification


PR:000000571 smad1 isoform 1 phosphorylated form, SMAD1/iso:1/PhosRes+

modification


PR:000000570 smad1 isoform 1 phosphorylated and ubiquitinated form, SMAD1/iso:1/PhosUbiq+

modification


PR:000000648 smad1 isoform 1 phosphorylated and ubiquitinated 1, SMAD1/iso:1/PhosUbiq:1

organism-modification


PR:000036553 smad1 isoform 1 phosphorylated and ubiquitinated 1 (human), hSMAD1/iso:1/PhosUbiq:1
Yes
modification


PR:000000647 smad1 isoform 1 phosphorylated 1, SMAD1/iso:1/Phos:1
Yes
organism-modification


PR:000026334 smad1 isoform 1 phosphorylated 1 (human), hSMAD1/iso:1/Phos:1
Yes
organism-modification


PR:000026724 smad1 isoform 1 phosphorylated 1 (mouse), mSMAD1/iso:1/Phos:1
Yes
modification


PR:000050148 smad1 phosphorylated 1, SMAD1/Phos:1

organism-modification


PR:000050147 smad1 phosphorylated 1 (human), hSMAD1/Phos:1

gene


PR:000000372 smad5, SMAD5

organism-gene


PR:P97454 mothers against decapentaplegic homolog 5 (mouse), mSMAD5

organism-sequence


PR:P97454-1 mothers against decapentaplegic homolog 5 isoform 1 (mouse), mSMAD5/iso:1
Yes
organism-modification


PR:000036563 smad5 isoform 1 phosphorylated 1 (mouse), mSMAD5/iso:1/Phos:1
Yes
organism-gene


PR:Q56I99 mothers against decapentaplegic homolog 5 (chicken), chick-SMAD5

organism-gene


PR:Q99717 mothers against decapentaplegic homolog 5 (human), hSMAD5

organism-sequence


PR:000029962 smad5 isoform 2 (human), hSMAD5/iso:2
Yes
organism-sequence


PR:Q99717-1 mothers against decapentaplegic homolog 5 isoform 1 (human), hSMAD5/iso:1
Yes
organism-modification


PR:000036562 smad5 isoform 1 phosphorylated 1 (human), hSMAD5/iso:1/Phos:1
Yes
organism-modification


PR:000049289 mothers against decapentaplegic homolog 5, initiator methionine removed form (human), hSMAD5/InitMet-

organism-modification


PR:000049290 mothers against decapentaplegic homolog 5, initiator methionine removed phosphorylated 1 (human), hSMAD5/InitMet-/Phos:1

organism-gene


PR:Q9R1V3 mothers against decapentaplegic homolog 5 (rat), rSMAD5

organism-gene


PR:Q9W7E7 mothers against decapentaplegic homolog 5 (zebrafish), z-SMAD5

sequence


PR:000000477 smad5 isoform 1, SMAD5/iso:1

organism-sequence


PR:P97454-1 mothers against decapentaplegic homolog 5 isoform 1 (mouse), mSMAD5/iso:1
Yes
organism-modification


PR:000036563 smad5 isoform 1 phosphorylated 1 (mouse), mSMAD5/iso:1/Phos:1
Yes
organism-sequence


PR:Q99717-1 mothers against decapentaplegic homolog 5 isoform 1 (human), hSMAD5/iso:1
Yes
organism-modification


PR:000036562 smad5 isoform 1 phosphorylated 1 (human), hSMAD5/iso:1/Phos:1
Yes
modification


PR:000000580 smad5 isoform 1 phosphorylated form, SMAD5/iso:1/PhosRes+

modification


PR:000000661 smad5 isoform 1 phosphorylated 1, SMAD5/iso:1/Phos:1

organism-modification


PR:000036562 smad5 isoform 1 phosphorylated 1 (human), hSMAD5/iso:1/Phos:1
Yes
organism-modification


PR:000036563 smad5 isoform 1 phosphorylated 1 (mouse), mSMAD5/iso:1/Phos:1
Yes
modification


PR:000026652 smad5 isoform 1, initiator methionine removed form, SMAD5/iso:1/InitMet-

sequence


PR:000000478 smad5 isoform 2, SMAD5/iso:2

organism-sequence


PR:000029962 smad5 isoform 2 (human), hSMAD5/iso:2
Yes
modification


PR:000018297 smad5, initiator methionine removed form, SMAD5/InitMet-

modification


PR:000026652 smad5 isoform 1, initiator methionine removed form, SMAD5/iso:1/InitMet-

organism-modification


PR:000049289 mothers against decapentaplegic homolog 5, initiator methionine removed form (human), hSMAD5/InitMet-

organism-modification


PR:000049290 mothers against decapentaplegic homolog 5, initiator methionine removed phosphorylated 1 (human), hSMAD5/InitMet-/Phos:1

gene


PR:000000375 smad9, SMAD9

organism-gene


PR:O15198 mothers against decapentaplegic homolog 9 (human), hSMAD9

organism-sequence


PR:000029959 smad9 isoform 3 (human), hSMAD9/iso:3
Yes
organism-sequence


PR:O15198-1 mothers against decapentaplegic homolog 9 isoform A (human), hSMAD9/iso:A

organism-modification


PR:000028350 smad9 isoform 3 phosphorylated 1 (human), hSMAD9/iso:3/Phos:1

organism-sequence


PR:O15198-2 mothers against decapentaplegic homolog 9 isoform B (human), hSMAD9/iso:B

organism-modification


PR:000049291 mothers against decapentaplegic homolog 9 phosphorylated 1 (human), hSMAD9/Phos:1

organism-modification


PR:000067869 mothers against decapentaplegic homolog 9 methylated 1 (human), hSMAD9/Me:1

organism-modification


PR:000085152 mothers against decapentaplegic homolog 9 methylated 2 (human), hSMAD9/Me:2

organism-gene


PR:O54835 mothers against decapentaplegic homolog 9 (rat), rSMAD9

organism-gene


PR:Q9JIW5 mothers against decapentaplegic homolog 9 (mouse), mSMAD9

organism-sequence


PR:Q9JIW5-1 mothers against decapentaplegic homolog 9 isoform 1 (mouse), mSMAD9/iso:1
Yes
organism-modification


PR:000036567 smad9 isoform 1 phosphorylated 1 (mouse), mSMAD9/iso:1/Phos:1
Yes
sequence


PR:000000482 smad9 isoform 1, SMAD9/iso:1

organism-sequence


PR:O15198-2 mothers against decapentaplegic homolog 9 isoform B (human), hSMAD9/iso:B

organism-sequence


PR:Q9JIW5-1 mothers against decapentaplegic homolog 9 isoform 1 (mouse), mSMAD9/iso:1
Yes
organism-modification


PR:000036567 smad9 isoform 1 phosphorylated 1 (mouse), mSMAD9/iso:1/Phos:1
Yes
modification


PR:000000585 smad9 isoform 1 phosphorylated form, SMAD9/iso:1/PhosRes+

modification


PR:000000666 smad9 isoform 1 phosphorylated 1, SMAD9/iso:1/Phos:1

organism-modification


PR:000036567 smad9 isoform 1 phosphorylated 1 (mouse), mSMAD9/iso:1/Phos:1
Yes
sequence


PR:000000484 smad9 isoform 3, SMAD9/iso:3

organism-sequence


PR:O15198-1 mothers against decapentaplegic homolog 9 isoform A (human), hSMAD9/iso:A

organism-modification


PR:000028350 smad9 isoform 3 phosphorylated 1 (human), hSMAD9/iso:3/Phos:1

modification


PR:000000586 smad9 isoform 3 phosphorylated form, SMAD9/iso:3/PhosRes+

modification


PR:000000667 smad9 isoform 3 phosphorylated 1, SMAD9/iso:3/Phos:1

organism-modification


PR:000028350 smad9 isoform 3 phosphorylated 1 (human), hSMAD9/iso:3/Phos:1

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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000000038 R-SMAD(BMP)

"A smad protein that mediates signal transduction through activation of bone morphogenetic protein (BMP) or anti-Mullerian hormone pathways." [PMID:11532220]		 acts_upstream_of_or_withinGO:0030509 BMP signaling pathway PANTHER:PTHR13703; PIRSF:PIRSF500500
PR:000000647 SMAD1/iso:1/Phos:1
BMP receptor-activated smad1
"A smad1 isoform 1 phosphorylated form in which the phosphorylation occurs at the C-terminal SSxS motif as a result of the activation of the bone morphogenetic protein (BMP) signaling pathway. Example: UniProtKB:Q15797-1, Ser-463/Ser-465, MOD:00046." [PMID:9136927]		 enablesGO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific PMID:10708949
PR:000026334 hSMAD1/iso:1/Phos:1
UniProtKB:Q15797-1, Ser-463/Ser-465, MOD:00046 | phospho-R-smad1 (human)
"A smad1 isoform 1 phosphorylated 1 in human. UniProtKB:Q15797-1, Ser-463/Ser-465, MOD:00046." [PRO:DAN, Reactome:R-HSA-201464, Reactome:R-HSA-201483]		 acts_upstream_of_or_withinGO:0007165 signal transduction PMID:9759503
GO:0030509 BMP signaling pathway PMID:8653785
enablesGO:0046332 SMAD binding with PR:Q13485 deletion target in pancreatic carcinoma 4 (human) PMID:9136927
located_inGO:0005634 nucleus PMID:11509558; PMID:9759503
PR:000026724 mSMAD1/iso:1/Phos:1
UniProtKB:P70340-1, Ser-463/Ser-465, MOD:00046
"A smad1 isoform 1 phosphorylated 1 in mouse. UniProtKB:P70340-1, Ser-463/Ser-465, MOD:00046." [PMID:10504300, PMID:12151307, PMID:12370310]		 acts_upstream_of_or_withinGO:0008285 negative regulation of cell population proliferation PMID:15899870
GO:0030509 BMP signaling pathway PMID:12370310; PMID:15198985
enablesGO:0005515 protein binding with PR:Q04211 BTG family member 2 (mouse) PMID:14633973
GO:0005515 protein binding with PR:Q8BGV5 mZNF8 PMID:14633973
GO:0005515 protein binding with PR:Q9QZH6 Ecsit PMID:14633973
located_inGO:0005634 nucleus PMID:10504300; PMID:12151307; PMID:12370310
GO:0005667 transcription factor complex PMID:14633973
GO:0005769 early endosome PMID:17592637
PR:000029959 hSMAD9/iso:3
SMAD8b (human)
"A mothers against decapentaplegic homolog 9 (human) that is a translation product of a transcript that lacks the last exon." [PMID:10583507, PRO:DAN]		 acts_upstream_of_or_withinGO:0030514 negative regulation of BMP signaling pathway PMID:10583507
enablesGO:0046332 SMAD binding PMID:10583507
located_inGO:0005737 cytoplasm PMID:10583507
PR:000029962 hSMAD5/iso:2

"A smad5 isoform 2 that is encoded in the genome of human." [PRO:DAN]		 enablesNOT GO:0046332 SMAD binding PMID:10845932
PR:000036553 hSMAD1/iso:1/PhosUbiq:1
UniProtKB:Q15797-1, Ser-463/Ser-465, MOD:00046|MOD:01148
"A smad1 isoform 1 phosphorylated and ubiquitinated 1 in human. UniProtKB:Q15797-1, Ser-463/Ser-465, MOD:00046|MOD:01148." [PMID:12857866, PRO:CNA, PRO:DAN]		 acts_upstream_of_or_withinGO:0030514 negative regulation of BMP signaling pathway PMID:12857866
PR:000036562 hSMAD5/iso:1/Phos:1
UniProtKB:Q99717-1, Ser-463/Ser-465, MOD:00046
"A smad5 isoform 1 phosphorylated 1 in human. UniProtKB:Q99717-1, Ser-463/Ser-465, MOD:00046." [PMID:8637600, PMID:8673135, PRO:CNA]		 acts_upstream_of_or_withinGO:0030509 BMP signaling pathway PMID:8637600
enablesGO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific PMID:8673135
PR:000036563 mSMAD5/iso:1/Phos:1
UniProtKB:P97454-1, Ser-463/Ser-465, MOD:00046
"A smad5 isoform 1 phosphorylated 1 in mouse. UniProtKB:P97454-1, Ser-463/Ser-465, MOD:00046." [PMID:10504300, PMID:15331632, PMID:16522160, PMID:9759503, PRO:CNA]		 acts_upstream_of_or_withinGO:0030509 BMP signaling pathway PMID:16522160
located_inGO:0005634 nucleus PMID:10504300; PMID:9759503
PR:000036567 mSMAD9/iso:1/Phos:1
UniProtKB:Q9JIW5-1, Ser-428/Ser-430, MOD:00046
"A smad9 isoform 1 phosphorylated 1 in mouse. UniProtKB:Q9JIW5-1, Ser-428/Ser-430, MOD:00046." [PMID:10814522, PMID:11163184, PMID:15542835, PRO:CNA]		 acts_upstream_of_or_withinGO:0030509 BMP signaling pathway PMID:11163184; PMID:15542835
enablesGO:0005515 protein binding PMID:11163184; PMID:15542835
located_inGO:0005634 nucleus PMID:10814522
PR:P70340-1 mSMAD1/iso:1

"A smad1 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]		 acts_upstream_of_or_withinGO:0030509 BMP signaling pathway PMID:15198985; PMID:15331632; PMID:17356069
located_inGO:0005737 cytoplasm PMID:10504300; PMID:17356069
PR:P97454-1 mSMAD5/iso:1

"A smad5 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]		 acts_upstream_of_or_withinGO:0007165 signal transduction PMID:16765933
GO:0030509 BMP signaling pathway PMID:16522160; PMID:16765933
located_inGO:0005737 cytoplasm PMID:10504300
PR:Q15797-1 hSMAD1/iso:1

"A smad1 isoform 1 that is encoded in the genome of human." [PRO:CNA]		 acts_upstream_of_or_withinGO:0007165 signal transduction PMID:8637600
GO:0030509 BMP signaling pathway PMID:8653785
enablesGO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific PMID:10708949
GO:0005102 signaling receptor binding PMID:9136927; PMID:9748228
GO:0005515 protein binding PMID:17356069
located_inGO:0005737 cytoplasm PMID:11509558
PR:Q99717-1 hSMAD5/iso:1

"A smad5 isoform 1 that is encoded in the genome of human." [PRO:CNA]		 acts_upstream_of_or_withinGO:0030509 BMP signaling pathway PMID:8673135
enablesGO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific PMID:8673135
PR:Q9JIW5-1 mSMAD9/iso:1

"A smad9 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]		 acts_upstream_of_or_withinGO:0048856 anatomical structure development PMID:15899870
located_inGO:0005622 intracellular anatomical structure PMID:10814522