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Protein Ontology report - activin receptor type-1
PR:000000067 - http://purl.obolibrary.org/obo/PR_000000067
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000000067   
  PRO nameactivin receptor type-1 
  Synonyms
PRO-Short-label: EXACT:ACVR1
Gene-based: RELATED:ACVRLK2 | Tgfb1
Other: EXACT:activin receptor type I | activin receptor-like kinase 2 | ACTR-I | ALK-2 | serine/threonine-protein kinase receptor R1 | SKR1 | TSK-7L
RELATED:TGF-B superfamily receptor type I | TSR-I
  Definition"A TGF-beta superfamily receptor type-1 that is a translation product of the human ACVR1 gene or a 1:1 ortholog thereof." [PRO:CNA] 
  PRO Categorygene 
  ParentPR:000000006
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 4                                        
         Sequence1                                                  Organism-Sequence 3                                        
         Modification3                                                  Organism-Modification 3                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
IUPHARobj:1785
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Protein Forms  Switch to Extended View   

Category  

PRO Form Name

Ann. Has Annotation?

Comp. In Complex?
gene



PR:000000067 activin receptor type-1, ACVR1


organism-gene



PR:P37172 activin receptor type-1 (mouse), mACVR1


organism-sequence



PR:P37172-1 activin receptor type-1 isoform 1 (mouse), mACVR1/iso:1


organism-modification



PR:000036436 activin receptor type-1 isoform 1, signal peptide removed phosphorylated 1 (mouse), mACVR1/iso:1/SigPep-/Phos:1

Yes

organism-gene



PR:P80201 activin receptor type-1 (rat), rACVR1


organism-gene



PR:Q04771 activin receptor type-1 (human), hACVR1


organism-sequence



PR:000000200 activin receptor type-1 sequence variant R206H (human), hACVR1/var:R206H

Yes

organism-sequence



PR:Q04771-1 activin receptor type-1 isoform 1 (human), hACVR1/iso:1


organism-modification



PR:000036435 activin receptor type-1 isoform 1, signal peptide removed phosphorylated 1 (human), hACVR1/iso:1/SigPep-/Phos:1

Yes

organism-modification



PR:000068633 activin receptor type-1 cysteinylated 1 (human), hACVR1/Cyst:1


organism-gene



PR:Q90ZK6 activin receptor type-1 (chicken), chick-ACVR1


sequence



PR:000000199 activin receptor type-1 isoform 1, ACVR1/iso:1


organism-sequence



PR:P37172-1 activin receptor type-1 isoform 1 (mouse), mACVR1/iso:1


organism-modification



PR:000036436 activin receptor type-1 isoform 1, signal peptide removed phosphorylated 1 (mouse), mACVR1/iso:1/SigPep-/Phos:1

Yes

organism-sequence



PR:Q04771-1 activin receptor type-1 isoform 1 (human), hACVR1/iso:1


organism-modification



PR:000036435 activin receptor type-1 isoform 1, signal peptide removed phosphorylated 1 (human), hACVR1/iso:1/SigPep-/Phos:1

Yes

modification



PR:000021938 activin receptor type-1 isoform 1, signal peptide removed form, ACVR1/iso:1/SigPep-


modification



PR:000000411 activin receptor type-1 isoform 1, signal peptide removed phosphorylated form, ACVR1/iso:1/SigPep-/PhosRes+


modification



PR:000000524 activin receptor type-1 isoform 1, signal peptide removed phosphorylated 1, ACVR1/iso:1/SigPep-/Phos:1


organism-modification



PR:000036435 activin receptor type-1 isoform 1, signal peptide removed phosphorylated 1 (human), hACVR1/iso:1/SigPep-/Phos:1

Yes

organism-modification



PR:000036436 activin receptor type-1 isoform 1, signal peptide removed phosphorylated 1 (mouse), mACVR1/iso:1/SigPep-/Phos:1

Yes

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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000000200
hACVR1/var:R206H
UniProtKB:Q04771, Arg-206, CHEBI:29979 | activin receptor type-1 sequence variant 1 (human)
associated_with_disease_progressionDO:13374 fibrodysplasia ossificans progressiva PMID:8397373
located_inGO:0005886 plasma membrane PMID:8397373
PR:000036435
hACVR1/iso:1/SigPep-/Phos:1
acts_upstream_of_or_withinGO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway PMID:8242742; PMID:8389764
enablesGO:0004675 transmembrane receptor protein serine/threonine kinase activity PMID:8389764
GO:0048185 activin binding PMID:8242742
located_inGO:0005886 plasma membrane PMID:8242742; PMID:8397373
GO:0048179 activin receptor complex PMID:8242742
PR:000036436
mACVR1/iso:1/SigPep-/Phos:1
acts_upstream_of_or_withinGO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway PMID:11376112