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Protein Ontology report - activin receptor type-2B

PR:000000071 - http://purl.obolibrary.org/obo/PR_000000071

Protein Forms

Annotations

Ontology Information

Show OBO stanza

PAF

PRO ID

PR:000000071

PRO name

activin receptor type-2B

Synonyms

PRO-Short-label:	EXACT:	ACVR2B
Other:	EXACT:	activin receptor type IIB \| ACTR-IIB

Definition

"A TGF-beta superfamily receptor type-2 with activin receptor domain that is a translation product of the human ACVR2B gene or a 1:1 ortholog thereof." [PRO:CNA]

PRO Category

gene

Parent

PR:000000007

Terms by PRO Category

Organism-Independent		Organism-Specific
Category	Number of Terms	Category	Number of Terms
Gene	1	Organism-Gene	4
Sequence	5	Organism-Sequence	9
Modification	2	Organism-Modification	4

Term Hierarchy
Visualization

DAG:

OLS:

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Related Cross References
Db identifiers	PIRSF:PIRSF500456;IUPHARobj:1792

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Protein Forms

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Category

PRO Form Name

Ann. Has Annotation?

Comp. In Complex?

gene

PR:000000071 activin receptor type-2B, ACVR2B

Yes

organism-gene

PR:P27040 activin receptor type-2B (mouse), mACVR2B

organism-sequence

PR:P27040-1 activin receptor type-2B isoform ActR-IIB1 (mouse), mACVR2B/iso:ActR-IIB1

Yes

organism-sequence

PR:P27040-2 activin receptor type-2B isoform ActR-IIB2 (mouse), mACVR2B/iso:ActR-IIB2

organism-modification

PR:000036442 activin receptor type-2B isoform ActR-IIB2 N-glycosylated and phosphorylated 1 (mouse), mACVR2B/iso:ActR-IIB2/NGlycoPhos:1

Yes

organism-sequence

PR:P27040-3 activin receptor type-2B isoform ActR-IIB3 (mouse), mACVR2B/iso:ActR-IIB3

Yes

organism-sequence

PR:P27040-4 activin receptor type-2B isoform ActR-IIB4 (mouse), mACVR2B/iso:ActR-IIB4

Yes

organism-gene

PR:P38445 activin receptor type-2B (rat), rACVR2B

organism-gene

PR:Q13705 activin receptor type-2B (human), hACVR2B

organism-sequence

PR:000000214 activin receptor type-2B sequence variant R40H (human), hACVR2B/var:R40H

Yes

organism-sequence

PR:000000215 activin receptor type-2B sequence variant V494I (human), hACVR2B/var:V494I

Yes

organism-sequence

PR:Q13705-1 activin receptor type-2B isoform ActR-IIB2 (human), hACVR2B/iso:ActR-IIB2

Yes

organism-modification

PR:000036443 activin receptor type-2B isoform ActR-IIB2 N-glycosylated and phosphorylated 1 (human), hACVR2B/iso:ActR-IIB2/NGlycoPhos:1

Yes

organism-sequence

PR:Q13705-2 activin receptor type-2B isoform ActR-IIBtrunc (human), hACVR2B/iso:ActR-IIB1

Yes

organism-modification

PR:000046259 activin receptor type-2B, signal peptide removed form (human), hACVR2B/SigPep-

organism-modification

PR:000076998 activin receptor type-2B phosphorylated 1 (human), hACVR2B/Phos:1

organism-gene

PR:Q90670 activin receptor type-2B (chicken), chick-ACVR2B

organism-sequence

PR:Q90670-1 activin receptor type-2B isoform ActR-IIB2 (chicken), chick-ACVR2B/iso:ActR-IIB2

sequence

PR:000000209 activin receptor type-2B isoform ActR-IIB2, ACVR2B/iso:ActR-IIB2

organism-sequence

PR:P27040-2 activin receptor type-2B isoform ActR-IIB2 (mouse), mACVR2B/iso:ActR-IIB2

organism-modification

PR:000036442 activin receptor type-2B isoform ActR-IIB2 N-glycosylated and phosphorylated 1 (mouse), mACVR2B/iso:ActR-IIB2/NGlycoPhos:1

Yes

organism-sequence

PR:Q13705-1 activin receptor type-2B isoform ActR-IIB2 (human), hACVR2B/iso:ActR-IIB2

Yes

organism-modification

PR:000036443 activin receptor type-2B isoform ActR-IIB2 N-glycosylated and phosphorylated 1 (human), hACVR2B/iso:ActR-IIB2/NGlycoPhos:1

Yes

organism-sequence

PR:Q90670-1 activin receptor type-2B isoform ActR-IIB2 (chicken), chick-ACVR2B/iso:ActR-IIB2

modification

PR:000000415 activin receptor type-2B isoform ActR-IIB2 glycosylated and phosphorylated form, ACVR2B/iso:ActR-IIB2/GlycoPhos+

modification

PR:000000529 activin receptor type-2B isoform ActR-IIB2 N-glycosylated and phosphorylated 1, ACVR2B/iso:ActR-IIB2/NGlycoPhos:1

organism-modification

PR:000036442 activin receptor type-2B isoform ActR-IIB2 N-glycosylated and phosphorylated 1 (mouse), mACVR2B/iso:ActR-IIB2/NGlycoPhos:1

Yes

organism-modification

PR:000036443 activin receptor type-2B isoform ActR-IIB2 N-glycosylated and phosphorylated 1 (human), hACVR2B/iso:ActR-IIB2/NGlycoPhos:1

Yes

sequence

PR:000000210 activin receptor type-2B isoform ActR-IIBtrunc, ACVR2B/iso:ActR-IIBtrunc

organism-sequence

PR:Q13705-2 activin receptor type-2B isoform ActR-IIBtrunc (human), hACVR2B/iso:ActR-IIB1

Yes

sequence

PR:000000211 activin receptor type-2B isoform ActR-IIB1, ACVR2B/iso:ActR-IIB1

organism-sequence

PR:P27040-1 activin receptor type-2B isoform ActR-IIB1 (mouse), mACVR2B/iso:ActR-IIB1

Yes

sequence

PR:000000212 activin receptor type-2B isoform ActR-IIB3, ACVR2B/iso:ActR-IIB3

organism-sequence

PR:P27040-3 activin receptor type-2B isoform ActR-IIB3 (mouse), mACVR2B/iso:ActR-IIB3

Yes

sequence

PR:000000213 activin receptor type-2B isoform ActR-IIB4, ACVR2B/iso:ActR-IIB4

organism-sequence

PR:P27040-4 activin receptor type-2B isoform ActR-IIB4 (mouse), mACVR2B/iso:ActR-IIB4

Yes

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Functional Annotation (PRO-centric view)

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PRO Term	GO Annotation		Evidence
PR:000000071 ACVR2B activin receptor type IIB \| ACTR-IIB	acts_upstream_of_or_within	GO:0032924 activin receptor signaling pathway	PIRSF:PIRSF500456
PR:000000071 ACVR2B activin receptor type IIB \| ACTR-IIB	enables	GO:0048185 activin binding	PIRSF:PIRSF500456
PR:000000214 hACVR2B/var:R40H UniProtKB:Q13705, Arg-40, CHEBI:29979 \| UniProtKB:Q13705-1, Arg-40, CHEBI:29979 \| activin receptor type-2B sequence variant 1 (human)	associated_with_disease_progression	DO:0050545 visceral heterotaxy	PMID:9916847
PR:000000215 hACVR2B/var:V494I UniProtKB:Q13705, Val-494, CHEBI:30009 \| UniProtKB:Q13705-1, Val-494, CHEBI:30009 \| activin receptor type-2B sequence variant 2 (human)	associated_with_disease_progression	DO:0050545 visceral heterotaxy	PMID:9916847
PR:000036442 mACVR2B/iso:ActR-IIB2/NGlycoPhos:1 activin receptor type-2B isoform 1 glycosylated and phosphorylated 1 (mouse) \| mACVR2B/iso:1/GlycoPhos:1	acts_upstream_of_or_within	GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway	PMID:8721982
		GO:0009952 anterior/posterior pattern specification	PMID:10452853; PMID:16991118
		GO:0032925 regulation of activin receptor signaling pathway	PMID:8721982
	enables	GO:0004675 transmembrane receptor protein serine/threonine kinase activity	PMID:1326537
		GO:0019838 growth factor binding	PMID:11459935; PMID:12414726
		NOT GO:0050431 transforming growth factor beta binding	PMID:1326537
PR:000036443 hACVR2B/iso:ActR-IIB2/NGlycoPhos:1 activin receptor type-2B isoform 1 glycosylated and phosphorylated 1 (human) \| hACVR2B/iso:1/GlycoPhos:1	enables	GO:0004675 transmembrane receptor protein serine/threonine kinase activity	PMID:8622651
		GO:0005515 protein binding	PMID:11279102; PMID:9872992
		GO:0016362 activin receptor activity, type II	PMID:8622651
	located_in	GO:0005886 plasma membrane	PMID:8161782
	located_in	GO:0048179 activin receptor complex	PMID:8622651
PR:P27040-1 mACVR2B/iso:ActR-IIB1	located_in	GO:0005886 plasma membrane	PMID:1310075
PR:P27040-1 mACVR2B/iso:ActR-IIB1	located_in	GO:0048179 activin receptor complex	PMID:1310075
PR:P27040-3 mACVR2B/iso:ActR-IIB3	located_in	GO:0005886 plasma membrane	PMID:1310075
PR:P27040-3 mACVR2B/iso:ActR-IIB3	located_in	GO:0048179 activin receptor complex	PMID:1310075
PR:P27040-4 mACVR2B/iso:ActR-IIB4	located_in	GO:0005886 plasma membrane	PMID:1310075
PR:P27040-4 mACVR2B/iso:ActR-IIB4	located_in	GO:0048179 activin receptor complex	PMID:1310075
PR:Q13705-1 hACVR2B/iso:ActR-IIB2	acts_upstream_of_or_within	GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway	PMID:8161782
PR:Q13705-2 hACVR2B/iso:ActR-IIB1 activin receptor type-2B isoform ActR-IIB1 (human)	enables	NOT GO:0016362 activin receptor activity, type II	PMID:9916847
	located_in	SO:0001587 stop_gained	PMID:9916847