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Protein Ontology report - fungal/metazoan cullin-1
PR:000000092 - http://purl.obolibrary.org/obo/PR_000000092
 
  Protein Forms  Complex  Annotations      
Ontology Information Show OBO stanza / PAF
  PRO ID
PR:000000092   
  PRO namefungal/metazoan cullin-1 
  Synonyms
PRO-Short-label: EXACT:CUL1
Other: EXACT:CUL-1
  Definition"A cullin that is a translation product of the human CUL1 gene or a 1:1 ortholog thereof in fungi or metazoa." [PRO:CNA] 
  PRO Categorygene 
  ParentPR:000000013 cullin
PR:000036194 eukaryotic protein
  TaxonNCBITaxon:33154 Opisthokonta
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 7                                        
         Sequence1                                                  Organism-Sequence 2                                        
         Modification2                                                  Organism-Modification 4                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Ann. Has Annotation?

Comp. In Complex?
gene


PR:000000092 fungal/metazoan cullin-1, CUL1
Yes
organism-gene


PR:O13790 cullin-1 (Schizosaccharomyces pombe 972h-), Spom972h-CUL1

organism-gene


PR:O60999 cullin-1 (Dictyostelium discoideum), Dicty-CUL1

organism-gene


PR:Q12018 cell division control protein 53 (yeast), yCUL1

organism-gene


PR:Q13616 cullin-1 (human), hCUL1

Yes
organism-sequence


PR:Q13616-1 cullin-1 isoform 1 (human), hCUL1/iso:1
Yes
organism-modification


PR:000036454 cullin-1 isoform 1 neddylated 1 (human), hCUL1/iso:1/Nedd:1
Yes
organism-modification


PR:000064861 cullin-1 neddylated 1 (human), hCUL1/Nedd:1

organism-modification


PR:000071994 cullin-1 methylated 1 (human), hCUL1/Me:1

organism-modification


PR:000075174 cullin-1 cysteinylated 1 (human), hCUL1/Cyst:1

organism-gene


PR:Q17389 cullin-1 (worm), CUL1 (worm)

organism-gene


PR:Q24311 cullin homolog 1 (fruit fly), fly-CUL1

organism-gene


PR:Q9WTX6 cullin-1 (mouse), mCUL1

organism-sequence


PR:Q9WTX6-1 cullin-1 isoform 1 (mouse), mCUL1/iso:1

sequence


PR:000000267 fungal/metazoan cullin-1 isoform 1, CUL1/iso:1

organism-sequence


PR:Q13616-1 cullin-1 isoform 1 (human), hCUL1/iso:1
Yes
organism-modification


PR:000036454 cullin-1 isoform 1 neddylated 1 (human), hCUL1/iso:1/Nedd:1
Yes
organism-sequence


PR:Q9WTX6-1 cullin-1 isoform 1 (mouse), mCUL1/iso:1

modification


PR:000000427 fungal/metazoan cullin-1 isoform 1 neddylated form, CUL1/iso:1/NeddLys+

modification


PR:000000542 fungal/metazoan cullin-1 isoform 1 neddylated 1, CUL1/iso:1/Nedd:1

organism-modification


PR:000036454 cullin-1 isoform 1 neddylated 1 (human), hCUL1/iso:1/Nedd:1
Yes
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CUL1 forms found in complexes   

CUL1 Component
 Complexes
PR:Q13616 hCUL1 PR:000026771 SCF beta-TrCP complex (human)
PR:000026772 SCF(Skp2) complex (human)
PR:000037513 FBXO4:CRYAB:Skp1:Cul1:Rbx1 complex (human)
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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000000092 CUL1
CUL-1
"A cullin that is a translation product of the human CUL1 gene or a 1:1 ortholog thereof in fungi or metazoa." [PRO:CNA]		 acts_upstream_of_or_withinGO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process PANTHER:PTHR11932
located_inGO:0019005 SCF ubiquitin ligase complex PANTHER:PTHR11932
PR:000036454 hCUL1/iso:1/Nedd:1
UniProtKB:Q13616-1, Lys-720, MOD:01150
"A fungal/metazoan cullin-1 isoform 1 neddylated 1 in human. UniProtKB:Q13616-1, Lys-720, MOD:01150." [PMID:10713156, PMID:10921923, PMID:17098746, PMID:8681378, PRO:CNA]		 acts_upstream_of_or_withinGO:0008285 negative regulation of cell population proliferation PMID:8681378
GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process PMID:10713156; PMID:10921923
GO:0051726 regulation of cell cycle PMID:8681378
GO:0097193 intrinsic apoptotic signaling pathway PMID:8681378
located_inGO:0019005 SCF ubiquitin ligase complex PMID:10713156; PMID:10921923; PMID:17098746
PR:Q13616-1 hCUL1/iso:1

"A fungal/metazoan cullin-1 isoform 1 that is encoded in the genome of human." [PRO:CNA]		 enablesGO:0005515 protein binding with PR:P62877-1 PMID:12504026; PMID:15537541
GO:0005515 protein binding with PR:Q86VP6-1 PMID:12504026; PMID:15537541
located_inNOT GO:0019005 SCF ubiquitin ligase complex PMID:10713156; PMID:10921923; PMID:12504026