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Protein Ontology report - growth/differentiation factor
PR:000000098 - http://purl.obolibrary.org/obo/PR_000000098
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000000098   
  PRO namegrowth/differentiation factor 
  Definition"A TGF-beta-like cystine-knot cytokine that is closely related to the BMP family. These are produced as dimeric precursors and undergo post-translational processing for activation, requiring cleavage to release the bioactive C-terminal peptide. GDFs act as signaling molecules during embryonic tendon/ligament formation." [PRO:CNA] 
  PRO Categoryfamily 
  ParentPR:000000008 TGF-beta-like cystine-knot cytokine
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Family1                                                  Organism-Family 0                                        
         Gene2                                                  Organism-Gene 5                                        
         Sequence3                                                  Organism-Sequence 9                                        
         Modification6                                                  Organism-Modification 3                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Ann. Has Annotation?

Comp. In Complex?
family


PR:000000098 growth/differentiation factor, FST/iso:2

gene


PR:000000281 growth/differentiation factor 5, GDF5
Yes
organism-gene


PR:P43026 growth/differentiation factor 5 (human), hGDF5

organism-sequence


PR:000000437 growth/differentiation factor 5 sequence variant C400Y (human), hGDF5/var:C400Y
Yes
organism-sequence


PR:000000438 growth/differentiation factor 5 sequence variant R438L (human), hGDF5/var:R438L
Yes
organism-sequence


PR:000000439 growth/differentiation factor 5 sequence variant L441P (human), hGDF5/var:L441P
Yes
organism-sequence


PR:P43026-1 growth/differentiation factor 5 isoform 1 (human), hGDF5/iso:1
Yes
organism-modification


PR:000036543 growth/differentiation factor 5 isoform 1 cleaved 1 (human), hGDF5/iso:1/Clv:1
Yes
organism-modification


PR:000047523 growth/differentiation factor 5, signal peptide removed form (human), hGDF5/SigPep-

organism-modification


PR:000036543 growth/differentiation factor 5 isoform 1 cleaved 1 (human), hGDF5/iso:1/Clv:1
Yes
organism-gene


PR:P43027 growth/differentiation factor 5 (mouse), mGDF5

organism-sequence


PR:000000441 growth/differentiation factor 5 sequence variant 5 (mouse), mGDF5/var:5
Yes
organism-sequence


PR:000036417 growth/differentiation factor 5 sequence variant V186* (mouse), mGDF5/var:V186*
Yes
organism-sequence


PR:P43027-1 growth/differentiation factor 5 isoform 1 (mouse), mGDF5/iso:1

organism-gene


PR:Q5KSY1 growth and differentiation factor-5 (rat), rGDF5

sequence


PR:000000436 growth/differentiation factor 5 isoform 1, GDF5/iso:1

organism-sequence


PR:P43026-1 growth/differentiation factor 5 isoform 1 (human), hGDF5/iso:1
Yes
organism-modification


PR:000036543 growth/differentiation factor 5 isoform 1 cleaved 1 (human), hGDF5/iso:1/Clv:1
Yes
organism-sequence


PR:P43027-1 growth/differentiation factor 5 isoform 1 (mouse), mGDF5/iso:1

modification


PR:000021914 growth/differentiation factor 5 isoform 1, signal peptide removed form, GDF5/iso:1/SigPep-

modification


PR:000000640 growth/differentiation factor 5 isoform 1 cleaved 1, GDF5/iso:1/Clv:1

organism-modification


PR:000036543 growth/differentiation factor 5 isoform 1 cleaved 1 (human), hGDF5/iso:1/Clv:1
Yes
modification


PR:000021929 growth/differentiation factor 5 proteolytic cleavage product, GDF5/ClvPrd

gene


PR:000000282 growth/differentiation factor 7, GDF7
Yes
organism-gene


PR:P43029 growth/differentiation factor 7 (mouse), mGDF7
Yes
organism-sequence


PR:P43029-1 growth/differentiation factor 7 isoform 1 (mouse), mGDF7/iso:1

organism-modification


PR:000036544 growth/differentiation factor 7 isoform 1 cleaved 1 (mouse), mGDF7/iso:1/Clv:1
Yes
organism-sequence


PR:P43029-2 growth/differentiation factor 7 isoform 2 (mouse), mGDF7/iso:2

organism-gene


PR:Q7Z4P5 growth/differentiation factor 7 (human), hGDF7

sequence


PR:000000442 growth/differentiation factor 7 isoform 1, GDF7/iso:1

organism-sequence


PR:P43029-1 growth/differentiation factor 7 isoform 1 (mouse), mGDF7/iso:1

organism-modification


PR:000036544 growth/differentiation factor 7 isoform 1 cleaved 1 (mouse), mGDF7/iso:1/Clv:1
Yes
modification


PR:000021915 growth/differentiation factor 7 isoform 1, signal peptide removed form, GDF7/iso:1/SigPep-

modification


PR:000000641 growth/differentiation factor 7 isoform 1 cleaved 1, GDF7/iso:1/Clv:1

organism-modification


PR:000036544 growth/differentiation factor 7 isoform 1 cleaved 1 (mouse), mGDF7/iso:1/Clv:1
Yes
sequence


PR:000000443 growth/differentiation factor 7 isoform 2, GDF7/iso:2

organism-sequence


PR:P43029-2 growth/differentiation factor 7 isoform 2 (mouse), mGDF7/iso:2

modification


PR:000021930 growth/differentiation factor 7 proteolytic cleavage product, GDF7/ClvPrd

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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000000281 GDF5
BMP14 | Bp | CDMP1 | BMP-14 | bone morphogenetic protein 14 | cartilage-derived morphogenetic protein 1 | CDMP-1 | GDF-5 | radotermin
"A growth/differentiation factor that is a translation product of the human GDF5 gene or a 1:1 ortholog thereof." [PRO:CNA]		 acts_upstream_of_or_withinGO:0030326 embryonic limb morphogenesis PANTHER:PTHR11848
PR:000000282 GDF7
GDF-7
"A growth/differentiation factor that is a translation product of the human GDF7 gene or a 1:1 ortholog thereof." [PRO:CNA]		 acts_upstream_of_or_withinGO:0007154 cell communication PANTHER:PTHR11848
PR:000000437 hGDF5/var:C400Y
UniProtKB:P43026, Cys-400, CHEBI:46858 | growth/differentiation factor 5 sequence variant 1 (human)
"A growth/differentiation factor 5 (human) that has a Tyr residue at the position equivalent to Cys-400 of the amino acid sequence represented by UniProtKB:P43026. UniProtKB:P43026, Cys-400, CHEBI:46858." [PMID:9288098, PRO:CNA, PRO:DAN]		 associated_with_disease_progressionDO:0080052 acromesomelic dysplasia, Grebe type UniProtKB_VAR:VAR_017407
enablesGO:0005515 protein binding with PR:000000164 BMP-2 PMID:9288098
NOT GO:0008083 growth factor activity PMID:9288098
located_inGO:0005622 intracellular anatomical structure PMID:9288098
PR:000000438 hGDF5/var:R438L
UniProtKB:P43026, Arg-438, CHEBI:30006 | growth/differentiation factor 5 sequence variant 2 (human)
"A growth/differentiation factor 5 (human) that has a Leu residue at the position equivalent to Arg-438 of the amino acid sequence represented by UniProtKB:P43026. UniProtKB:P43026, Arg-438, CHEBI:30006." [PMID:16532400, PRO:CNA, PRO:DAN]		 associated_with_disease_progressionDO:0050794 multiple synostoses syndrome PMID:16532400
located_inGO:0005615 extracellular space PMID:16532400
PR:000000439 hGDF5/var:L441P
UniProtKB:P43026, Leu-441, CHEBI:50342 | growth/differentiation factor 5 sequence variant 3 (human)
"A growth/differentiation factor 5 (human) that has a Pro residue at the position equivalent to Leu-441 of the amino acid sequence represented by UniProtKB:P43026. UniProtKB:P43026, Leu-441, CHEBI:50342." [PMID:12121354, PMID:16127465, PRO:CNA, PRO:DAN]		 associated_with_disease_progressionDO:0050790 fibular hypoplasia and complex brachydactyly UniProtKB_VAR:VAR_017408
PR:000000441 mGDF5/var:5

"A growth/differentiation factor 5 (mouse) that has a frameshift at the position equivalent to residue 376 of the amino acid sequence represented by UniProtKB:P43027." [PMID:8145850, PRO:CNA, PRO:DAN]		 associated_with_disease_progressionMP:0006279 abnormal limb development PMID:8145850
PR:000036417 mGDF5/var:V186*
UniProtKB:P43027, 1-185 | bp-3J (mouse)
"A growth/differentiation factor 5 (mouse) that has a polypeptide truncation after the position equivalent to residue 185 of the amino acid sequence represented by UniProtKB:P43027. UniProtKB:P43027, 1-185." [PMID:8145850, PRO:CNA]		 associated_with_disease_progressionMP:0006279 abnormal limb development PMID:8145850
located_inSO:0001587 stop_gained PMID:8145850
PR:000036543 hGDF5/iso:1/Clv:1
UniProtKB:P43026-1, 382-501 | PRO_0000033913
"A growth/differentiation factor 5 isoform 1 cleaved 1 in human. UniProtKB:P43026-1, 382-501." [PMID:15752764, PMID:15890363, PMID:16532400, PMID:8589725, PMID:8962721, PMID:9288098, PRO:CNA]		 enablesGO:0005102 signaling receptor binding PMID:15752764; PMID:15890363
GO:0005515 protein binding PMID:9288098
GO:0008083 growth factor activity PMID:8589725
GO:0042803 protein homodimerization activity PMID:15752764; PMID:8962721
located_inGO:0005615 extracellular space PMID:16532400
PR:000036544 mGDF7/iso:1/Clv:1
UniProtKB:P43029-1, 316-461 | PRO_0000033925
"A growth/differentiation factor 7 isoform 1 cleaved 1 in mouse. UniProtKB:P43029-1, 316-461." [PMID:12741987, PRO:CNA]		 acts_upstream_of_or_withinGO:0007411 axon guidance PMID:12741987
enablesGO:0005515 protein binding with PR:000036516 mBMP7/iso:1/mature PMID:12741987
located_inGO:0005576 extracellular region PMID:12741987
PR:P43026-1 hGDF5/iso:1

"A growth/differentiation factor 5 isoform 1 that is encoded in the genome of human." [PRO:CNA]		 acts_upstream_of_or_withinGO:0007179 transforming growth factor beta receptor signaling pathway PMID:7961761
GO:0007267 cell-cell signaling PMID:8589725
PR:P43029 mGDF7
Gdf-7 | Gdf7 | GDF-7 (mouse)
"A growth/differentiation factor 7 that is encoded in the genome of mouse." [OMA:P43029, PRO:DNx]		 acts_upstream_of_or_withinGO:0045165 cell fate commitment PMID:15883363