back to PRO homepage
  Home |   Linked Open Data |   Browse |  
Search

 |   Statistics |   Download
 RACE-PRO
 PRO tracker
 Community
 PRO Consortium
 Publications
 Documentation

Protein Ontology report - smad ubiquitination regulatory factor
PR:000000127 - http://purl.obolibrary.org/obo/PR_000000127
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza / PAF
  PRO ID
PR:000000127   
  PRO namesmad ubiquitination regulatory factor 
  Synonyms
Other: EXACT:smurf
  Definition"A HECT domain-containing E3 ubiquitin-protein ligase with WW domains that mediates smad ubiquitination." [PRO:CNA] 
  PRO Categoryfamily 
  ParentPR:000000016 HECT domain-containing E3 ubiquitin-protein ligase with WW domains
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Family1                                                  Organism-Family 0                                        
         Gene2                                                  Organism-Gene 6                                        
         Sequence2                                                  Organism-Sequence 6                                        
         Modification0                                                  Organism-Modification 3                                        
  Term Hierarchy
  Visualization
DAG: OLS:
Back to top
Related Cross References

  Db identifiers
PIRSF:PIRSF500454
Back to top
Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Ann. Has Annotation?

Comp. In Complex?
family


PR:000000127 smad ubiquitination regulatory factor, ACVRL1
Yes
gene


PR:000000361 E3 ubiquitin-protein ligase SMURF1, SMURF1

organism-gene


PR:Q9CUN6 E3 ubiquitin-protein ligase SMURF1 (mouse), mSMURF1
Yes
organism-sequence


PR:Q9CUN6-1 E3 ubiquitin-protein ligase SMURF1 isoform Short (mouse), mSMURF1/iso:Short
Yes
organism-modification


PR:000049754 E3 ubiquitin-protein ligase SMURF1 phosphorylated 1 (mouse), mSMURF1/Phos:1

organism-modification


PR:000049755 E3 ubiquitin-protein ligase SMURF1 unphosphorylated 1 (mouse), mSMURF1/UnPhos:1

organism-gene


PR:Q9HCE7 E3 ubiquitin-protein ligase SMURF1 (human), hSMURF1
Yes
organism-sequence


PR:Q9HCE7-1 E3 ubiquitin-protein ligase SMURF1 isoform Long (human), hSMURF1/iso:Long

organism-sequence


PR:Q9HCE7-2 E3 ubiquitin-protein ligase SMURF1 isoform Short (human), hSMURF1/iso:Short
Yes
organism-modification


PR:000075773 E3 ubiquitin-protein ligase SMURF1 cysteinylated 1 (human), hSMURF1/Cyst:1

organism-gene


PR:Q9V853 E3 ubiquitin-protein ligase Smurf1 (fruit fly), fly-SMURF1

sequence


PR:000000466 E3 ubiquitin-protein ligase SMURF1 isoform Short, SMURF1/iso:Short

organism-sequence


PR:Q9CUN6-1 E3 ubiquitin-protein ligase SMURF1 isoform Short (mouse), mSMURF1/iso:Short
Yes
organism-sequence


PR:Q9HCE7-2 E3 ubiquitin-protein ligase SMURF1 isoform Short (human), hSMURF1/iso:Short
Yes
gene


PR:000000362 E3 ubiquitin-protein ligase SMURF2, SMURF2

organism-gene


PR:A2A5Z6 E3 ubiquitin-protein ligase SMURF2 (mouse), mSMURF2

organism-sequence


PR:A2A5Z6-1 E3 ubiquitin-protein ligase SMURF2 isoform 1 (mouse), mSMURF2/iso:1

organism-sequence


PR:A2A5Z6-2 E3 ubiquitin-protein ligase SMURF2 isoform m2 (mouse), mSMURF2/iso:m2

organism-gene


PR:A9JRZ0 E3 ubiquitin-protein ligase SMURF2 (zebrafish), z-SMURF2

organism-gene


PR:Q9HAU4 E3 ubiquitin-protein ligase SMURF2 (human), hSMURF2
Yes
organism-sequence


PR:Q9HAU4-1 E3 ubiquitin-protein ligase SMURF2 isoform 1 (human), hSMURF2/iso:1

sequence


PR:000043363 E3 ubiquitin-protein ligase SMURF2 isoform 1, SMURF2/iso:1

organism-sequence


PR:A2A5Z6-1 E3 ubiquitin-protein ligase SMURF2 isoform 1 (mouse), mSMURF2/iso:1

organism-sequence


PR:Q9HAU4-1 E3 ubiquitin-protein ligase SMURF2 isoform 1 (human), hSMURF2/iso:1

Back to top
Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000000127 ACVRL1
smurf
"A HECT domain-containing E3 ubiquitin-protein ligase with WW domains that mediates smad ubiquitination." [PRO:CNA]		 acts_upstream_of_or_withinGO:0006511 ubiquitin-dependent protein catabolic process PIRSF:PIRSF500454
GO:0007398 ectoderm development PIRSF:PIRSF500454
GO:0009968 negative regulation of signal transduction PIRSF:PIRSF500454
PR:Q9CUN6 mSMURF1
Smurf1 | HECT-type E3 ubiquitin transferase SMURF1 (mouse) | SMAD ubiquitination regulatory factor 1 (mouse) | SMAD-specific E3 ubiquitin-protein ligase 1 (mouse)
"An E3 ubiquitin-protein ligase SMURF1 that is encoded in the genome of mouse." [OMA:Q9CUN6, PRO:DNx]		 acts_upstream_of_or_withinGO:0030514 negative regulation of BMP signaling pathway PMID:14711801
PR:Q9CUN6-1 mSMURF1/iso:Short
Smurf1 isoform 1 (mouse)
"An E3 ubiquitin-protein ligase SMURF1 isoform Short that is encoded in the genome of mouse." [PRO:CNA]		 located_inGO:0005622 intracellular anatomical structure PMID:14711801
PR:Q9HAU4 hSMURF2
SMURF2 | HECT-type E3 ubiquitin transferase SMURF2 (human) | SMAD ubiquitination regulatory factor 2 (human) | SMAD-specific E3 ubiquitin-protein ligase 2 (human)
"An E3 ubiquitin-protein ligase SMURF2 that is encoded in the genome of human." [PRO:CNA, UniProtKB:Q9HAU4]		 acts_upstream_of_or_withinGO:0006511 ubiquitin-dependent protein catabolic process PMID:14755250
GO:0017015 regulation of transforming growth factor beta receptor signaling pathway PMID:11016919; PMID:11158580; PMID:11163210; PMID:15862290
enablesGO:0004842 ubiquitin-protein transferase activity PMID:14755250
GO:0005515 protein binding PMID:14755250
PR:Q9HCE7 hSMURF1
KIAA1625 | SMURF1 | HECT-type E3 ubiquitin transferase SMURF1 (human) | SMAD ubiquitination regulatory factor 1 (human) | SMAD-specific E3 ubiquitin-protein ligase 1 (human)
"An E3 ubiquitin-protein ligase SMURF1 that is encoded in the genome of human." [PRO:CNA, UniProtKB:Q9HCE7]		 acts_upstream_of_or_withinGO:0030514 negative regulation of BMP signaling pathway PMID:10458166
PR:Q9HCE7-2 hSMURF1/iso:Short

"An E3 ubiquitin-protein ligase SMURF1 isoform Short that is encoded in the genome of human." [PRO:CNA]		 acts_upstream_of_or_withinGO:0006511 ubiquitin-dependent protein catabolic process PMID:12857866
GO:0006511 ubiquitin-dependent protein catabolic process PMID:12857866
GO:0036211 protein modification process PMID:10458166
enablesGO:0004842 ubiquitin-protein transferase activity PMID:10458166
GO:0005515 protein binding PMID:11278251; PMID:16299379
located_inGO:0005622 intracellular anatomical structure PMID:10458166