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Protein Ontology report - lefty 1

PR:000000287 - http://purl.obolibrary.org/obo/PR_000000287

Protein Forms

Annotations

Ontology Information

Show OBO stanza

PRO ID

PR:000000287

PRO name

lefty 1

Synonyms

PRO-Short-label:	EXACT:	LEFTY1
Gene-based:	RELATED:	LEFTB \| LEFTYB \| UNQ278/PRO317
Other:	EXACT:	protein lefty-1 \| stimulated by retinoic acid gene 3 protein
	RELATED:	Ebaf \| left-right determination factor B \| Lefty \| protein lefty-B \| Stra3 \| TGF-beta-4 \| Tgfb4 \| transforming growth factor beta-4

Definition

"A lefty protein that is a translation product of the human LEFTY1 gene or a 1:1 ortholog thereof." [PRO:CNA]

PRO Category

gene

Parent

PR:000000102 lefty protein

Terms by PRO Category

Organism-Independent		Organism-Specific
Category	Number of Terms	Category	Number of Terms
Gene	1	Organism-Gene	1
Sequence	1	Organism-Sequence	2
Modification	3	Organism-Modification	4

Term Hierarchy
Visualization

DAG:

OLS:

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Protein Forms

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Category

PRO Form Name

Ann. Has Annotation?

Comp. In Complex?

gene

PR:000000287 lefty 1, LEFTY1

organism-gene

PR:O75610 left-right determination factor 1 (human), hLEFTY1

organism-sequence

PR:O75610-1 left-right determination factor 1 isoform 1 (human), hLEFTY1/iso:1

organism-modification

PR:000036546 lefty 1 isoform 1 cleaved 1 (human), hLEFTY1/iso:1/Clv:1

Yes

organism-modification

PR:000036548 lefty 1 isoform 1 cleaved 2 (human), hLEFTY1/iso:1/Clv:2

Yes

organism-modification

PR:000077301 left-right determination factor 1 phosphorylated 1 (human), hLEFTY1/Phos:1

sequence

PR:000000450 lefty 1 isoform 1, LEFTY1/iso:1

organism-sequence

PR:O75610-1 left-right determination factor 1 isoform 1 (human), hLEFTY1/iso:1

organism-modification

PR:000036546 lefty 1 isoform 1 cleaved 1 (human), hLEFTY1/iso:1/Clv:1

Yes

organism-modification

PR:000036548 lefty 1 isoform 1 cleaved 2 (human), hLEFTY1/iso:1/Clv:2

Yes

organism-sequence

PR:Q64280-1 left-right determination factor 1 isoform 1 (mouse), mLEFTY1/iso:1

Yes

organism-modification

PR:000036547 lefty 1 isoform 1 cleaved 1 (mouse), mLEFTY1/iso:1/Clv:1

Yes

modification

PR:000000643 lefty 1 isoform 1 cleaved 1, LEFTY1/iso:1/Clv:1

organism-modification

PR:000036546 lefty 1 isoform 1 cleaved 1 (human), hLEFTY1/iso:1/Clv:1

Yes

organism-modification

PR:000036547 lefty 1 isoform 1 cleaved 1 (mouse), mLEFTY1/iso:1/Clv:1

Yes

modification

PR:000000644 lefty 1 isoform 1 cleaved 2, LEFTY1/iso:1/Clv:2

organism-modification

PR:000036548 lefty 1 isoform 1 cleaved 2 (human), hLEFTY1/iso:1/Clv:2

Yes

modification

PR:000025431 lefty 1 proteolytic cleavage product, LEFTY1/ClvPrd

modification

PR:000000643 lefty 1 isoform 1 cleaved 1, LEFTY1/iso:1/Clv:1

organism-modification

PR:000036546 lefty 1 isoform 1 cleaved 1 (human), hLEFTY1/iso:1/Clv:1

Yes

organism-modification

PR:000036547 lefty 1 isoform 1 cleaved 1 (mouse), mLEFTY1/iso:1/Clv:1

Yes

modification

PR:000000644 lefty 1 isoform 1 cleaved 2, LEFTY1/iso:1/Clv:2

organism-modification

PR:000036548 lefty 1 isoform 1 cleaved 2 (human), hLEFTY1/iso:1/Clv:2

Yes

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Functional Annotation (PRO-centric view)

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PRO Term	GO Annotation		Evidence
PR:000036546 hLEFTY1/iso:1/Clv:1 UniProtKB:O75610-1, 77-366 \| PRO_0000033811 "A lefty 1 isoform 1 cleaved 1 in human. UniProtKB:O75610-1, 77-366." [PMID:11278322, PRO:CNA]	located_in	GO:0005615 extracellular space	PMID:11278322
PR:000036547 mLEFTY1/iso:1/Clv:1 UniProtKB:Q64280-1, 77-368 \| PRO_0000033809 "A lefty 1 isoform 1 cleaved 1 in mouse. UniProtKB:Q64280-1, 77-368." [PMID:15004567, PMID:18039650, PRO:CNA]	acts_upstream_of_or_within	GO:0008285 negative regulation of cell population proliferation	PMID:15004567
	acts_upstream_of_or_within	GO:0009948 anterior/posterior axis specification	PMID:15004567
	located_in	GO:0005615 extracellular space	PMID:18039650
PR:000036548 hLEFTY1/iso:1/Clv:2 UniProtKB:O75610-1, 135-366 "A lefty 1 isoform 1 cleaved 2 in human. UniProtKB:O75610-1, 135-366." [PMID:11278322, PRO:CNA]	acts_upstream_of_or_within	GO:0043406 positive regulation of MAP kinase activity	PMID:11278322
	located_in	GO:0005615 extracellular space	PMID:11278322
PR:Q64280-1 mLEFTY1/iso:1 "A lefty 1 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]	acts_upstream_of_or_within	GO:0008285 negative regulation of cell population proliferation	PMID:15004567
	acts_upstream_of_or_within	GO:0009948 anterior/posterior axis specification	PMID:15004567